Clinical Trial ID* Official Title Start
Year
Country**
Bone Condition
NCT00775931
NCT00851162
NCT01087398
Allogeneic Hematopoietic Stem Cell Transplantation For Severe
Osteopetrosis
Using Mesenchymal Stem Cells to Fill Bone Void Defects in
Patients With Benign Bone Lesions
Hematopoietic Stem Cell Transplantation for Malignant Infantile
Osteopetrosis
Cardiovascular Disease
CTRI/2008/091/000232 Efficacy Of Stem Cell In Improving The Functioning Of Heart In
Heart Attack Patients
NCT00333827 Multicenter Randomized Study Of Cell Therapy In Cardiopathies
- Dilated Cardiomyopathy
NCT00349271
NCT00350766
Multicenter Randomized Study Of Cell Therapy In Cardiopathies
- Chagas Cardiomyopathy
Multicenter Prospective Randomized Double Blind Trial of Bone
Marrow Mononuclear Cells Transplantation Through
NCT00356733
NCT00363324
NCT00394498
Intracoronary Injection in Patients With Acute Myocardial
Infarction
Mechanisms of Erythropoietin Action in the Cardiorenal
Syndrome
Effects of Autologous Bone Marrow Cells on Acute ST-Elevation
Myocardial Infarction
Stem Cell Mobilization by G-CSF by Granulocyte Colony
Stimulating Factor Post Myocardial Infarction to Promote
Myocyte Repair
NCT00434616
NCT00462774
NCT00501917
NCT00526253
Security and Effectiveness of Autologous Bone Marrow Stem
Cell Transplantation to Avoid Amputations in Patients With
Limb-Threatening Ischemia: A Multicentric Randomized Placebo-
Controlled Double-Blind Study
Bypass Surgery and CD133 Marrow Cell Injection for Treatment of Ischemic Heart Failure (Cardio133)
Single Center Prospective Randomized Partly-Double Blinded
Controlled Trial to Assess the Safety and Feasibility of
Intracoronary Cell Infusion Mobilized With G-CSF and
Darbepoetin and Their Effects on Improvement of Cardiac
Function in Patients With Myocardial Infarction: Myocardial
Regeneration and Angiogenesis in Myocardial Infarction With G-
CSF and Erythropoietin Mobilization and Intra-Coronary Cell
Infusion –5-Combination Cytokine Therapy Trial
A Multicenter Study to Assess the Safety and Cardiovascular
Effects of Myocell™ Implantation by a Catheter Delivery System in Congestive Heart Failure Patients Post Myocardial
Infarction(s)
2008 USA
2009 USA
2009 Iran
2007 India
2006 Brazil
2006 Brazil
2006 Brazil
2006 Netherlands
2005 Finland
2005 Canada
2007 Germany
2007 Germany
2007 South Korea
2007 USA

NCT00650143
NCT00725738
NCT00732953
NCT00743639
NCT00747708
NCT00765453
NCT00797056
NCT00841958
NCT00911339
NCT00936234
NCT00950274
NCT00955669
NCT01067326
NCT01067339
NCT01167751
NCT01187654
NCT01216995
NCT01245335
Cartilage Condition
Safety and Efficacy of Sitagliptin Plus Granulocyte-colony
Stimulating Factor in Patients Suffering From Acute Myocardial
Infarction
Intracoronary Autologous Stem Cell Transplantation in ST
Elevation Myocardial Infarction: TRACIA Study
Prevention of Restenosis After Genous Stent Implantation Using a Paclitaxel Eluting Balloon in Coronary Arteries - a Randomized
Clinical Trial
Autologous Transplantation of Bone Marrow Mononuclear
Stem-Cells for Dilated Cardiomyopathy: Randomized Clinical
Trial
Randomised Control Trial to Compare the Effects of G-CSF and
Autologous Bone Marrow Progenitor Cells Infusion on the
Quality of Life and Left Ventricular Function in Patients With
Heart Failure Secondary to Ischaemic Heart Disease
Randomised Controlled Clinical Trial of the Use of Autologous
Bone Marrow Derived Progenitor Cells to Salvage Myocardium in Patients With Acute Anterior Myocardial Infarction
Pilot Study of Stem Cell Mobilization by G-CSF to Treat Severe
Peripheral Artery Disease (STEMPAD Trial)
Efficacy of the Endocardial Stem Cells Implantation in Ischemic
Heart Failure Patients
Mobilization of Endothelial Progenitor Cells Induced by
Atorvastatin in Patients With Stable Coronary Artery Disease
Treated With Anti-CD 34 Antibodies Coated Stents
Functional Improvement of Progenitor Cells and Endothelial
Function by Vildagliptin in Diabetes Mellitus (FINNjA-DM)
Intramyocardial Transplantation of Bone Marrow Stem Cells for
Improvement of Post-infarct Myocardial Regeneration in
Addition to CABG Surgery: a Controlled Prospective Randomized
Double Blinded Multicenter Trial (PERFECT)
Autologous Transplantation of Bone Marrow Mesenchymal
Stem Cells on Diabetic Foot
The Effect of Tekturna on Endothelial Function and Endothelial
Progenitor Cells in Patients With Early Atherosclerosis
Lp-PLA2 Progenitor Cells and Coronary Atherosclerosis in
Humans AIM III
Autologous Bone Marrow Derived Ac 133+ And Mono Nuclear
Cells In-Patient With Acute Myocardial Infarction During
Coronary Artery Bypass Grafting (CABG) A Randomized Phase Iii
Clinical Trial
Comparison The Therapeutic Outcomes Of Bone Marrow
Derived Ac 133+ And Mono-Nuclear Cells (MNC) Implantation In
Patient With Acute Myocardial Infarction Underwent PCI
Procedure
Safety And Efficacy Of Adrcs Delivered Via The Intracoronary
Route In The Treatment Of Patients With St-Elevation Acute
Myocardial Infarction - The Advance Study
Pivotal Study Of The Safety And Effectiveness Of Autologous
Bone Marrow Aspirate Concentrate (BMAC) For The Treatment
Of Critical Limb Ischemia Due To Peripheral Arterial Disease
2008 Germany
2008 Mexico
2009 Germany
2005 Brazil
2005 UK
2008 UK
2008 USA
2007 Russia
2009 Italy
2009 Germany
2009 Germany
2009 China
2010 USA
2010 USA
2008 Iran
2009 Iran
2011 Netherlands
2011 USA

NCT00891501
NCT01041001
The Use of Autologous Bone Marrow Mesenchymal Stem Cells in the Treatment of Articular Cartilage Defects
Randomized Open-Label Multi-Center and Phase 3 Clinical Trial to Compare the Efficacy and Safety of Cartistem® and
Microfracture in Patients With Knee Articular Cartilage Injury or
Defect
2006
2009
Egypt
South Korea
Crohn's Disease
NCT00297193
NCT00482092
NCT00543374
NCT01233960
Autologous Stem Cell Transplantation for Crohn’s Disease: ASTIC 2006 UK
A Phase III Multicenter Placebo-Controlled Randomized Double-
Blind Study to Evaluate the Safety and Efficacy of PROCHYMAL™
(ex Vivo Cultured Adult Human Mesenchymal Stem Cells)
Intravenous Infusion for the Induction of Remission in Subjects
Experiencing Treatment-Refractory Moderate-to-Severe Crohn's
Disease
A Phase III Multicenter Placebo-controlled Randomized Doubleblind Durability and Retreatment Study to Evaluate the Safety and Efficacy of PROCHYMAL™ (ex Vivo Cultured Adult Human
Mesenchymal Stem Cells) Intravenous Infusion for the
Maintenance and Re-induction of Clinical Benefit and Remission in Subjects Experiencing Treatment-refractory Moderate-tosevere Crohn's Disease
A Multicenter Open-Label Study To Evaluate The Safety Of
Prochymal® (Remestemcel-L) Intravenous Infusion In Subjects
Who Have Received Previous Remestemcel-L Induction
Treatment For Treatment-Refractory Moderate-To-Severe
Crohn’s Disease
Diabetes
NCT01065298
NCT01157403
Efficacy Of Autologous Bone Marrow Derived Stem Cell
Transplantation In Patients With Type 2 Diabetes Mellitus
Autologous Transplantation Of Mesenchymal Stem Cells For
Treatment Of Patients With Onset Of Type 1 Diabetes
Multiple Sclerosis
NCT00273364 Hematopoietic Stem Cell Therapy for Patients With
Inflammatory Multiple Sclerosis Failing Interferon: A
Randomized Study
Ocular Condition
NCT01123044
NCT01237600
Transplantation of Cultivated Corneal Epithelial Sheet in Patients
With Ocular Surface Disease
Efficacy Of Cultivated Corneal Epithelial Stem Cell For Ocular
Surface Reconstruction
Scleroderma
NCT00114530 Scleroderma: Cyclophosphamide or Transplantation (SCOT)
NCT00871221
NCT00872508
Mechanistic Study: Vascular Cells and the Pathogenesis od
Systemic Sclerosis
Mechanistic Study: Molecular Analysis of T Cell Immune
Recovery for the SCOT Trial
Spinal Cord Injury
CTRI/2009/091/000613 A clinical study to evaluate the safety and efficacy of R-HSC-001
(autologous stem cells) in patients with Spinal Cord Injury
Other
2007 USA
2007
2010
2009
2010
2006
2011
2008
2005 n/a
2009
2008
USA
USA
India
China
USA
Malaysia
Thailand
USA
USA
USA
India

NCT00023192
NCT00306332
NCT00366145
NCT00469729
NCT00475410
NCT00654433
Treatment of Chronic Granulomatous Disease With Allogeneic
Stem Cell Transplantation Versus Standard of Care
T-cell and B-cell Depletion in Allogeneic Peripheral Blood Stem
Cell Transplantation by Using Immunomagnetic Negative and
Positive Selection Procedures
A Phase III Randomized Double Blind Placebo-Controlled Study to Evaluate the Efficacy and Safety of Prochymal (Ex Vivo
Cultured Adult Human Mesenchymal Stem Cells) Infusion for the
Treatment of Patients Who Have Failed to Respond to Steroid
Treatment for Acute GVHD
A Multi-Center Multi-National Historical Cohort Controlled Study to Evaluate Efficacy and Safety of Transplantation of StemEx®
Umbilical Cord Blood Stem and Progenitor Cells Expanded Ex
Vivo in Subjects With Hematologic Malignancies Following
Myeloablative Therapy
A Phase III Multicenter Single Blind Randomized Comparative and Add-on Clinical Trial in Three Parallel Groups to Evaluate
Efficacy and Safety of a New Therapy With Adipose-Derived
Autologous Stem Cells for the Treatment of Complex Perianal
Fistulas in Patients Without Inflammatory Bowel Disease
A Phase III Trial of ALD-101 Adjuvant Therapy of Unrelated
Umbilical Cord Blood Transplantation (UCBT) in Patients With
Inborn Errors of Metabolism
2001 USA
2006 Netherlands
2006 USA
2007 Israel
2007 Spain
2008 USA
NCT00992147
NCT01115634
A Phase II/III Clinical Study of ANTG-adip for the Treatment of
Depressed Scar to Evaluate Safety and Efficacy
Autologous Transplantation of Cultured Fibroblast for Facial
Contour Deformities
2004 South Korea
2008 Iran
Clinical Trial ID* Official Title Start
Year
Country**
Drug treatments for SC mobilization
NCT00126100
NCT00523393
NCT00536887
NCT00699686
NCT00701220
A Randomized Clinical Trial of Stem Cell Mobilization by
Granulocyte-Colony-Stimulating Factor in Patients With Acute
Myocardial Infarction Regenerate Vital Myocardium by Vigorous
Activation of Bone Marrow Stem Cells (REVIVAL-2) Trial
Prospective Influence of Bedtime Insulin Glargine on
Mobilization and Function of Endothelial Progenitor Cells in
Patients With Type 2 Diabetes: a Partially Double-Blind
Randomized Three-Arm Unicenter Study
Phase 4 Study of Atorvastatin 10mg vs 40mg in Follow-up CFR in
AMI Patients
Effects of Adding Basal Insulin on Endothelial Progenitor Cell
Levels in Poorly-Controlled Type 2 Diabetic Patients With
Cardiovascular Disease A Randomized Cross-Over Study
Comparing Insulin Detemir and Glargine
Statin Induced Augmentation of Circulating Endothelial
2004 Germany
2007 Germany
2005 South Korea
2008 Italy
2007 USA

NCT00702936
NCT00770835
NCT01041287
NCT01096875
Progenitor Cells and Myocardial Viability in Patients With
Ischemic and Nonischemic Cardiomyopathy
Telmisartan vs Ramipril for Reduction of Inflammation and
Recruitment of Endothelial Progenitor Cells After Acute
Coronary Syndrome
Effects of Pioglitazone on Endothelial Progenitor Cells in Type 2
Diabetic Patients With Vascular Complications - The SPLENDOR
Study
Effect of Nebivolol on Oxidative Stress and Endothelial
Progenitor Cells in Subjects With Hypertension
Assessment of the Effects of Atorvastatin on Endothelial
Progenitor Cells After Coronary ByPass Surgery A Randomized
Controlled Trial
NCT01102699
NCT01212653
Bone Marrow Responsiveness to Pharmacologic Mobilization of
Progenitor Cells in Type 2 Diabetic and Non-diabetic Patients
Effect Of Anti-Tnf(Alpha)Treatment On Circulating Endothelial
Progenitor Cells (EPCs) And Vascular Stiffness In Ankylosing
Spondylitis
Stents (for capturing endothelial progenitor cells)
NCT00349895
NCT00494247
NCT01272895
Healthy Endothelial Accelerated Lining Inhibits Neointimal
Growth A Clinical Multi-Center Prospective Non-Randomized
Study
Comparison of Efficiency of High Dose Atorvastatin and
Endothelial Progenitor-Capture Stents and Bare Metal Stents in
Reduction of Neointimal Formation in Patients With Non ST-
Segment Elevation Acute Coronary Syndromes
Evaluation Of Endothelial Progenitor Cell (EPC) Capturing
(Genous) Stent After Coronary Stenting Utilizing Optical
Coherence Tomography (OCT) The Ego Study
Other
2007 Italy
2009 Italy
2009 USA
2010 Turkey
2010 Italy
2010 China
2006 Netherlands
2007 Poland
2010 China
CTRI/2009/091/000954 Safety and efficacy of patient`s own stem cells in prevention of
NCT00346970 amputation in patients with chronic critical limb due to obstruction of blood flow in arteries of the affected limb(s).
Randomized Clinical Trial to Study the Effect of Extended
NCT00616135
Release Niacin on Endothelial Function Oxidative Stress and
Endothelial Progenitor Cells in Patients With the Metabolic
Syndrome
A Clinical Evaluation Of Adipose Derived Regenerative Cells In
The Treatment Of Patients With Breast Deformities Post
Segmental Breast Resection (Lumpectomy) With Or Without
Radiation Therapy A Phase IV Post Market Study
2009 India
2006 Germany
2008 UK

Clinical Trial ID* Official Title Start
Year
Amyotrophic Lateral Sclerosis
NCT00397423
NCT00748501
NCT00855400
NCT01051882
NCT01082653
NCT01142856
NCT01254539
Granulocyte-Colony Stimulating Factor Treatment for
Amyotrophic Lateral Sclerosis: A Randomized Control Trial
Study Assessing Clinical Response
A Phase 2 Repeat-Dosing Clinical Trial of SB-509 in Subjects
With Amyotrophic Lateral Sclerosis
Phase I/II Clinical Trial on the Use of Autologous Bone Marrow
Stem Cells in Amyotrophic Lateral Sclerosis
A Phase I/II Open Label Study to Evaluate Safety Tolerability and Therapeutic Effects of Transplantation of Autologous
Cultured Mesenchymal Bone Marrow Stromal Cells Secreting
Neurotrophic Factors (MSC-NTF) in ALS Patients
Phase I Single Center Prospective Non-randomized Open Label
SafetyEfficacy Study of the Infusion of Autologous Bone
Marrow-derived Stem Cells in Patients With Amyotrophic
Lateral Sclerosis
A Single Patient Treatment Protocol for Autologous
Mesenchymal Stem Cell Intraspinal Therapy in Amyotrophic
Lateral Sclerosis (ALS)
Phase I/II clinical trial on the use of autologous bone marrow stem cells in amyotrophic lateral sclerosis (extension CMN/ELA)
Cerebral Palsy
ChiCTR-TNC-10001076 In Vivo Tracking of Feridex Labeled Bone Marrow Mesenchymal
Stem Cells after Transplantation
ChiCTR-TNRC-
10000928
Effect of Bone Marrow Mesenchymal Stem Cell on GMFM
Scores of Children with Cerebral Palsy in Clinical Trial
CTRI/2010/091/00043
5
NCT01019733
Clinical study on the use of ex vivo expanded Allogenic
Mesenchymal Stem Cells for Cerebral Palsy
NCT01072370
Intrathecal Autologous Stem Cells for Children With
HipoxicIschemic Brain Injury
A Placebo-Controlled Observer-Blinded Crossover Study to
Evaluate the Safety and Effectiveness of a Single Autologous
NCT01193660
Cord Blood Stem Cell Infusion for the Treatment of Cerebral
Palsy in Children
Double-blind randomized controlled trial to evaluate the efficacy and safety of a combination therapy of allogenic umbilical cord blood and erythropoietin for children with cerebral palsy
Diabetic Neuropathy
NCT00282685
NCT00665145
NCT00730561
Restoration of Nerve Functions by Intra-Arterial
Transplantation of Bone Marrow Progenitor Cells in Patients
With Diabetic Poly Neuropathy (PNP)
A Phase 2 Study of Stem-Cell-Mobilization in Subjects With
Diabetic Neuropathy Receiving SB-509
Autologous Hematopoietic Stem Cell Transplantation for the
2006
2008
2007
2011
2010
2010
2010
2010
2009
2010
2009
2010
2010
2005
2008
2006
Country*
*
China
USA
Spain
Israel
USA
USA
Spain
China
China
India
Mexico
USA
South
Korea
Germany
USA
Mexico

Treatment of Limb Ischemia and Diabetic Neuropathy in
Patients With Diabetes Mellitus Type 2:A Randomized
Controlled Trial
Multiple Sclerosis
NCT00017628
NCT00040482
NCT00273364
NCT00288626
NCT00342134
NCT00395200
NCT00497952
NCT00781872
NCT00813969
Phase I Study of High-Dose Cyclophosphamide and Total Body
Irradiation With T Lymphocyte-Depleted Autologous Peripheral
Blood Stem Cell or Bone Marrow Rescue in Patients With
Multiple Sclerosis
Intensive Immunosuppression Followed by Rescue With CD34
Selected T Cell Depleted Leukopheresis Products in Patients
With Multiple Sclerosis
Hematopoietic Stem Cell Therapy for Patients With
Inflammatory Multiple Sclerosis Failing Interferon: A
Randomized Study
A Phase II Study of High-Dose Immunosuppressive Therapy
(HDIT) Using Carmustine Etoposide Cytarabine and Melphalan
(BEAM) and Thymoglobulin and Autologous CD34+
Hematopoietic Stem Cell Transplant (HCT) for the Treatment of
Poor Prognosis Multiple Sclerosis
Immunological Mechanisms of Immune Ablation and
Autologous Hematopoietic Stem Cell Transplantation in
Secondary Progressive Multiple Sclerosis
Autologous Adult Human Mesenchymal Stem Cells: a
Neuroprotective Therapy for Multiple Sclerosis
Allogeneic Stem Cell Transplantation for the Treatment of
Multiple Sclerosis
Explorative Trial to Investigate the Migration Ability of
Mesenchymal Bone Marrow Stem Cells (MSC) in the Central
Nervous System (CNS) Following Their Intrathecal
Administration in Severe Cases of Multiple Sclerosis (MS)
A Phase I Study to Assess the Feasibility Safety and Tolerability of Autologous Mesenchymal Stem Cell Transplantation in
Patients With Relapsing Forms of Multiple Sclerosis
NCT01056471 Multicenter Clinical Trial Phase I/II Randomized Placebocontrolled Study to Evaluate Safety and Feasibility of Therapy
With Two Different Doses of Autologous Mesenchymal Stem
Cells in Patients With Secondary Progressive Multiple Sclerosis
Who do Not Respond to Treatment
NCT01099930
NCT01228266
Targeting Multiple Sclerosis as an Autoimmune Disease With
Intensive Immunoablative Therapy and Immunological
Reconstitution: A Potential Curative Therapy for Patients With a
Predicted Poor Prognosis
Autologous mesenchymal stem cell transplantation in multiple sclerosis a randomized double-blind crossover with placebo phase II study
Neuronal Ceroid Lipfuscinosis
NCT00337636
NCT01238315
A Phase I Study of the Safety and Preliminary Effectiveness of
Human CNS Stem Cells (HuCNS-SC) in Patients With Neuronal
Ceroid Lipofuscinosis Caused by Palmitoyl Protein Thioesterase
1 (PPT1) or Tripeptidyl Peptidase 1 (TPP-I) Deficiency
A phase Ib study of the safety and preliminary efficacy of
2001
1999
2006
2006
2002
2008
2007
2006
2009
2010
2001
2010
2006
2010
USA
USA
USA
USA
USA
UK
USA
Israel
USA
Spain
Canada
Spain
USA
USA

allogeneic intracerebral human central nervous system stem cell transplantation in subjects with non-refractory infantile and late infantile neuronal ceroid lipofuscinosis
Parkinson's Disease
CTRI/2010/091/00043
2
NCT00976430
Clinical study on the use of ex vivo expanded allogeneic mesenchymal stem cells for Parkinson's disease
To Study the Safety and Efficacy of Bone Marrow Derived
Mesenchymal Stem Cells Transplant in Parkinson's Disease
Pelizaeus-Merzbacher Disease
NCT01005004 Phase I Study of the Safety and Preliminary Efficacy of
Intracerebral Transplantation of HuCNS-SC® Cells for Connatal
Pelizaeus-Merzbacher Disease (PMD)
Spinal Cord Injury
CTRI/2009/091/00061
3
CTRI/2010/091/00104
3
NCT00816803
NCT01162915
NCT01186679
A clinical study to evaluate the safety and efficacy of R-HSC-001
(autologous stem cells) in patients with Spinal Cord Injury
Regeneration of Chronic Injured Spinal Cord by stem Cell
Transplantation: A Clinical Trial.
Autologous Bone Marrow Derived Cell Transplant in Spinal Cord
Injury Patients
Phase I single center trial to asses safety and tolerability of the intrathecal infusion of ex-vivo expanded bone-marrow derived mesenchymal stem cells for the treatment of spinal cord injury
Surgical transplantation of autologous bone marrow stem cells with glial scar resection for patients of chronic spinal cord injury and intra-thecal injection for acute and subacute injury - a preliminary study
Stroke
CTRI/2008/091/00004
6
ISRCTN16784092
Stem cells therapy for patients with acute ischemic stroke.
ISRCTN63336619
NCT00362414
NCT00473057
NCT00535197
NCT00663416
NCT00715364
A randomised placebo-controlled pilot trial of granulocytecolony stimulating factor in mobilising bone marrow stem cells in sub-acute stroke the stem cell trial of recovery enhancement after stroke (STEMS) pilot study
Stem cell trial of recovery enhancement after stroke 2
(STEMS2) pilot randomised placebo-controlled trial of granulocyte-colony stimulating factor in mobilising bone marrow stem cells in sub-acute stroke
Safety of Beta-hCG + Erythropoietin in Acute Stroke
Phase I Study of Autologous Bone Marrow Cell Transplantation in Patient With Ischemic Stroke
A Phase I/II Safety and Tolerability Study Following the
Autologous Infusion of Immuno-Selected CD34+ Subset Bone
Marrow Stem Cells Into Patients With Acute Total Anterior
Circulation Ischaemic Stroke
A Phase IIb Prospective Randomized Double-blind Placebo
Controlled Study of NTx™-265: Human Chorionic Gonadotropin
(hCG) and Epoetin Alfa (EPO) in Acute Ischemic Stroke Patients
(REGENESIS)
A Phase IIb Prospective Randomized Double-blind Placebo
Controlled Study of NTx™-265: Human Chorionic Gonadotropin
(hCG) and Epoetin Alfa (EPO) in Acute Ischemic Stroke Patients
2010
2009
2009
2008
2006
2005
2010
2008
2009
2003
2007
2006
2005
2007
2008
2009
India
India
USA
India
India
Egypt
USA
India
India
UK
UK
USA
Brazil
UK
Canada
USA

NCT00761982
NCT00859014
NCT00875654
NCT00901381
NCT00938314
NCT00950521
NCT01091701
NCT01151124
NCT01239602
NCT01249287
Autologous Bone Marrow Stem Cells in Middle Cerebral Artery
Acute Stroke Treatment
SafetyFeasibility of Autologous Mononuclear Bone Marrow
Cells in Stroke Patients
Cell Therapy by Intravenous Injection of Mesenchymal Stem
Cells After Stroke
Open Prospective Randomized Controlled Trial of Efficacy and
Safety of Granulocyte-Colony Stimulating Factor Leukostim for
Acute Ischemic Stroke
A Phase IIb Prospective Randomized Double-blind Placebo
Controlled Multicenter Dose Escalation Study of NTx®-265:
Human Chorionic Gonadotropin (hCG) and Epoetin Alfa (EPO) in
Acute Ischemic Stroke Patients (REGENESIS-LED)
Phase II Study of Autologous Peripheral Blood CD34 Stem Cell
Implantation in Chronic Stroke Patients
A Randomized Double Blind Multicentric Placebo Controlled
Single Dose Phase -I II Study Assessing The Safety And Efficacy
Of Intravenous Ex Vivo Cultured Adult Allogenic Mesenchymal
Stem Cells In Patients With Ischemic Cerebral Stroke
A Phase I Safety Trial of CTX0E03 Drug Product Delivered
Intracranially in the Treatment of Patients With Stable Ischemic
Stroke
The variation of movement related cortical potential corticocortical inhibition and motor evoked potential in intracerebral implantation of antologous peripheral blood stem cells(CD34)in old ischemic stroke
FMRI in monitoring intracerebral stem cell implantation for chronic stroke patients
Traumatic Brain Injury
CTRI/2010/091/00043
6
NCT00254722
NCT01239706
An open label, non randomized, uncontrolled, bio interventional, single centric, pilot study in Traumatic Brain
Injury
Safety of Autologous Stem Cell Treatment for Traumatic Brain
Injury in Children a phase iia single centre open label study to characterize the safety of human chorionic gonadotropin (hcg) and epoetin alfa
(epo) in traumatic brain injury dosing tier 1
Other
ChiCTR-TRC-10000922 Autologous transplantation of cord blood derived stem cells for neonatal hypoxic - ischemic encephalopatly
NCT00278629 High Dose Cyclophosphamide & ATG With Hematopoietic Stem
Cell Support in Patients With Chronic Inflammatory
Demyelinating Polyneuropathy: A Phase I Trial
NCT00283023
NCT00424489
NCT00716066
Phase 1: Oligodendrocyte Progenitor Cell Culture From Human
Brain
Hematopoietic Stem Cell Therapy for Patients With Refractory
Myasthenia Gravis
A Pilot Study of High-Dose Immunosuppressive Therapy Using
Carmustine Etoposide Cytarabine and Melphalan (BEAM) +
Thymoglobulin Followed by Syngeneic or Autologous
Hematopoietic Cell Transplantation for Patients With
2008
2009
2010
2007
2009
2009
2011
2010
2010
2009
2009
2006
2010
Spain
USA
France
Russia
Canada
Taiwan
Malaysia
UK
Taiwan
Taiwan
India
USA
Canada
2008 China
2005 USA
2007 Thailand
2002 USA
2008 USA

NCT00755586
NCT00787722
NCT00911365
NCT00916266
Autoimmune Neurologic Diseases
Autologous Bone Marrow Transplantation for Muscle
Improvement in Traumatic Brachial Plexus Injuries
Trial of High Dose Immunosuppressive Therapy With
Hematopoietic Stem Cell Support in Devic's Disease
A Double-blind Placebo-controlled Randomized Clinical Trial of
Autologous Mesenchymal Stem Cells in Patients With Multiple
System Atrophy
Phase 1 Study of Autologous Bone Marrow Stem Cells
Transplantation in Patients With Temporal Lobe Epilepsy
Adult Neuronal Progenitor Stem Cell Project
2009 Netherlands
2008 USA
2008 South Korea
2008 Brazil
NCT00927108 2009 Thailand
Clinical Trial ID* Official Title Start
Year
Country**
Heart Diseases
ACTRN12605000050651 Granulocyte-colony stimulating factor (g-csf) mobilised autologous endothelial progenitor cells for refractory ischaemic heart disease
ACTRN12607000354482 Adult stem cells and g-csf in chronic ischaemic heart disease
ACTRN12609001045202 Comparison of intracoronary selected CD 133+ bone marrow stem cells in cardiac recovery after acute myocardial infarct and left ventricular dysfunction: COMPARE-AMI a randomized controlled double blind clinical study
ChiCTR-TRC-08000080 Efficacy and safety of mesenchymal stem cell injection for the treatment of acute myocardial infarction-a single blinding muticenter randomized control trial.
CTRI/2008/091/000232 Efficacy of stem cell in improving the functioning of heart in heart attack patients
CTRI/2009/091/000437 Allogenic mesenchymal stem cells in patients with Dilated
Cardiomyopathy
CTRI/2009/091/000590 Clinical trial to study the safety and efficacy of stemcell therapy in patients with heart diseases
CTRI/2010/091/000626 Autologous Stem cell Transplantation in Ischaemic
Cardiomyopathy with diffuse Coronary Heart Disease.
CTRI/2010/091/000643 Intra Coronary Autologous Stem Cell Transplantation in Acute
Myocardial Infarction (AMI
CTRI/2010/091/000644 Functional Restoration of Infracted/ Scarred Myocardium
Through Transplantation of Bone Marrow Stem Cells: A Clinical
Trial
IRCT138902113799N2 The efficacy of intramyocardial injection of bone marrowderived mesenchymal and CD133+ stem cells on improvement of cardiac ejection fraction in patients undergoing CABG in
Shariati Hospital
2004 Australia
2007 Australia
2007 Canada
n/a China
2007 India
2009 India
2010 India
2006 India
2006 India
2007 India
2009 Iran

ISRCTN49998633
ISRCTN65630838
Intramyocardial application of stem cells in combination with transmyocardial laser revascularisation in coronary artery bypass graft patients
Selected autologous bone marrow cell transplant following trans-mural myocardial infarction in patients undergoing coronary surgery a prospective double-blind randomised controlled trial
ISRCTN71717097
ISRCTN74381875
ISRCTN75217135
JPRN-UMIN000000656 Clinical trial of mesenchymal stem cell transplantation for severe heart failure
NCT00043628
NCT00053456
Stem Cell Mobilization as Therapy for Chronic Myocardial
Ischemia in Patients With Coronary Artery Disease
Stem Cell Mobilization For Improvement in Vascular Function and Myocardial Perfusion in Patients Undergoing Cardiac
Rehabilitation
NCT00081913
Bone-marrow derived stem cell transplantation in patients undergoing left ventricular restoration surgery for dilated ischaemic end-stage heart failure
Percutaneous randomised infusion of marrow aspirate to improve ventricular efficiency
A pilot study to evaluate the efficacy of combined transplantation of progenitor cells and coronary artery bypass grafting (topcabg)
NCT00090558
Injection of Autologous CD34-Positive Cells for
Neovascularization and Symptom Relief in Patients With
Myocardial Ischemia
Effect of Nitric Oxide Donor on Endothelial Progenitor Cells in
Patients With Coronary Artery Disease
NCT00114452
NCT00126100
NCT00128258
NCT00130377
NCT00135850
A Phase 1 Randomized Double-Blind Placebo-Controlled Dose
Escalation Multicenter Study to Determine the Safety of
Intravenous Ex-Vivo Cultured Adult Human Mesenchymal Stem
Cells (Provacel) Following Acute Myocardial Infarction
A Randomized Clinical Trial of Stem Cell Mobilization by
Granulocyte-Colony-Stimulating Factor in Patients With Acute
Myocardial Infarction Regenerate Vital Myocardium by
Vigorous Activation of Bone Marrow Stem Cells (REVIVAL-2)
Trial
Phase 1 Study: Autologous Bone Marrow Progenitor Cell
Treatment for Heart Failure
Phase 1 Study: Autologous Bone Marrow Progenitor Cell
Treatment for Patients With Congestive Heart Failure
Undergoing CABG Surgery
The Effect of Mobilized Stem Cell by G-CSF and VEGF Gene
Therapy in Patients With Stable Severe Angina Pectoris
NCT00135928
NCT00154466
NCT00199823
NCT00200707
Bone Marrow Stimulation With G-CSF in Acute Myocardial
Infarction
An Association Study Between Cardiac Rehabilitation and Stem
Cell Mobilization in Patients With Myocardial Infarction
Autologous Stem Cell Transplantation in Acute Myocardial
Infarction
Intracoronary Injection of Autologous Bone Marrow
Mononuclear Cells for Severe Myocardial Infarction
2007 Germany
2008 UK
2009 UK
2006 UK
2004 UK
2003 Japan
2002 USA
2003 USA
2004 USA
2004 USA
2005 USA
2004 Germany
2005 USA
2005 USA
2003 Denmark
2003 Denmark
2004 Taiwan
2003 Norway
2004 France

NCT00203203
NCT00208767
NCT00215124
NCT00221182
NCT00235417
NCT00260338
NCT00264316
NCT00268307
NCT00272571
NCT00275977
NCT00279539
NCT00284713
NCT00289822
NCT00291629
NCT00300053
NCT00307879
NCT00308633
NCT00313339
Randomized Controlled Single Blind Trial of Autologous Bone
Marrow Mononuclear Cells Under Electromechanical Guidance for Therapeutic Angiogenesis
Effect of Valsartan on Endothelial Function Oxidative Stress
Carotid Atherosclerosis and Endothelial Progenitor Cells
(EFFERVESCENT)
Phase I - II Safety Study of Filgrastim (Neupogen) to Improve
Left Ventricular Function After Severe Acute Myocardial
Infarction
Phase I II Clinical Trial Regarding Vascular Regeneration
Therapy by Transplantation of Autologous Peripheral Blood
Endothelial Progenitor Cells (CD34+ Cells) in No-Option
Patients With Chronic Myocardial Ischemia
Stem Cell Therapy in Chronic Ischemic Heart Failure
Stem Cell Therapy for Vasculogenesis in Patients With Severe
Myocardial Ischemia
A Double-Blind Randomised Controlled Study of Autologous
Bone Marrow-Derived Stem Cell Transfer In Patients With ST-
Segment Elevation Myocardial Infarction
Cellular Transplantation of Autologous Bone Marrow-Derived
Stem Cells Following Myocardial Infarction
The Effects of External Counter Pulsation Therapy (ECPT) on the Number and Function of Circulating Endothelial Progenitor
Cells in Patients With Angina Pectoris
Treatment of Myocardial Infarction With Autologous Bone
Marrow Derived Stem Cells phVEGF165 GENE TRANSFER TO PROMOTE ANGIOGENESIS IN
PATIENTS WITH ISCHEMIC HEART FAILURE
Transplantation Of Progenitor Cells And Recovery Of Left
Ventricular Function In Patients With Nonischemic Dilatative
Cardiomyopathy
Cell Therapy for Coronary Heart Disease: Infusion of
Autologous Ex Vivo Cultivated Endothelial Progenitor Cells
(EPCs)” and Autologous Bone Marrow Progenitor Cells in
Crossover Design for Improvement of Vascularization and
Cardiac Function
Myocardial Regeneration and Angiogenesis in Myocardial
Infarction With G-CSF and Intra-Coronary Stem Cell Infusion-3-
DES (MAGIC Cell-3-DES)
A Double-blind Prospective Randomized Placebo-controlled
Study to Determine the Tolerability Efficacy Safety and Dose
Range of Intramyocardial Injections of G-CSF Mobilized Auto--
CD34+ Cells for Reduction of Angina Episodes in Patients With
Refractory Chronic Myocardial Ischemia (ACT34-CMI)
Phase 2 MAGIC Cell (Myocardial Regeneration and
Angiogenesis in Myocardial Infarction With G-CSF and Intra-
Coronary Stem Cell Infusion) Trial
Mechanism and Vascular Effects of Endothelial Progenitor Cell
Mobilization in Patients With Coronary Artery Disease
Undergoing Cardiac Rehabilitation
AMORCYTE MYOCARDIAL REPAIR STUDY- A Phase I Trial of
Intra-Coronary Infusion of Bone Marrow Derived Autologous
2004 USA
n/a USA
n/a USA
2005 Japan
2005 Denmark
2005 Denmark
2003 Belgium
2005 USA
2004 Israel
2006 Denmark
2008 USA
2004 Germany
2002 Germany
2004 South Korea
2006 USA
2004 South Korea
2006 USA
2006 USA

NCT00314366
NCT00316381
NCT00326989
NCT00333827
NCT00346177
NCT00349271
NCT00349895
NCT00350766
NCT00355186
NCT00356733
NCT00363324
NCT00365326
NCT00383630
NCT00384514
NCT00384982
NCT00389545
NCT00394498
NCT00395811
CD34+ Selected Cells in Patients With Acute Myocardial
Infarction (AMRS)
Phase IB Randomized Controlled Double-Blind Trial of
Intramyocardial Injection of Autologous Aldehyde
Dehydrogenase-Bright Stem Cells Under Electromechanical
Guidance for Therapeutic Angiogenesis
Myocardial REGeneration by Intracoronary Infusion of Selected
Population of stEm Cells in Acute Myocardial iNfarcTion
Randomized Multicenter Trial
Extracorporal Shock Wave Therapy for Induction of Therapeutic
Neovascularization and Homing of Bone Marrow Progenitor
Cells in Patients With Chronic Ischemic Heart Disease
Multicenter Randomized Study Of Cell Therapy In
Cardiopathies - Dilated Cardiomyopathy
Injection of Autologous CD34+ Cells for Neovascularization and
Symptom Relief in Patients With Myocardial Ischemia and LVEF
< 40%
Multicenter Randomized Study Of Cell Therapy In
Cardiopathies - Chagas Cardiomyopathy
Healthy Endothelial Accelerated Lining Inhibits Neointimal
Growth A Clinical Multi-Center Prospective Non-Randomized
Study
Multicenter Prospective Randomized Double Blind Trial of Bone
Marrow Mononuclear Cells Transplantation Through
Intracoronary Injection in Patients With Acute Myocardial
Infarction
SWiss Multicenter Intracoronary Stem Cells Study in Acute
Myocardial Infarction (SWISS-AMI)
Mechanisms of Erythropoietin Action in the Cardiorenal
Syndrome
Effects of Autologous Bone Marrow Celss on Acute ST-
Elevation Myocardial Infarction
2006
2004
2006
2006
2009
2006
2006
2006
2006
2006
2005
USA
Poland
Germany
Brazil
USA
Brazil
Netherlands
Brazil
Switzerland
Netherlands
Finland
Safety and Efficacy of Autologous Intracoronary Stem Cell
Injections in Total Coronary Artery Occlusions
The Effect of Intramyocardial Injection of Immunoselected
Bone Marrow Cells on Myocardial Function in LVAD Bridge to
Transplant Patients
A Study for Testing Safety and Efficacy of the Administration of
Blood-Borne Autologous Endothelial Progenitor Cells to
2006
2007
2004
USA
USA
Israel
Alleviate Anginal Symptoms and Myocardial Ischemia in
Patients With Severe Anginal Syndrome
Myocardial Stem Cell Administration After Acute Myocardial
Infarction (MYSTAR) Study: A Multicenter Randomized Trial
Comparing Early and Late Intracoronary or Combined
(Intramyocardial and Intracoronary) Administration of Stem
Cells
Intracoronary Stem Cells in Large Myocardial Infarction
2005 Austria
n/a Czech
Republic
Stem Cell Mobilization by G-CSF by Granulocyte Colony
Stimulating Factor Post Myocardial Infarction to Promote
Myocyte Repair
2005 Canada
Stem Cell Therapy to Improve Myocardial Function in Patients 2007 China

NCT00397592
NCT00416663
NCT00417417
NCT00418418
NCT00426868
NCT00431145
NCT00437710
NCT00442806
NCT00457379
NCT00462774
NCT00463853
NCT00474461
NCT00480961
NCT00494247
NCT00501917
NCT00523224
Undergoing Coronary Artery Bypass Grafting (CABG)
The Effect of Exogenous Growth Hormone on the Mobilization of Endothelial Progenitor Cells
A Study for Testing Efficacy and Safety of the Administration of
Vescell(TM) (Blood-Borne Autologous Angiogenic Cell
Precursors) to Alleviate Anginal Symptoms and Myocardial
Ischemia in Severe Anginal Syndrome +- Heart Failure
Effects of Interleukin-1 Inhibition on C-Reactive Protein Levels
Endothelial Progenitor Cell Mobilization and Endothelial
Function in Patients With Coronary Artery Disease
Combined CABG and Stem-Cell Transplantation for Heart
Failure
A Randomized Clinical Trial of adiPose-deRived stEm &
Regenerative Cells In the Treatment of Patients With Non revaScularizable ischEmic Myocardium - The PRECISE Trial
Influence of Combined Therapy of Niacin and Statins on Stem
Cell Mobilization and Inflammatory Parameters in Patients
Suffering From Coronary Artery Disease – Randomized Clinical
Study -
Cardiac Study Cellular Cardiomyoplasty of Infarcted Failed
Myocardium by Autologous Intracoronary Mononuclear Bone
Marrow Cell Transplantation in Humans
A Randomized Clinical Trial of AdiPOse-Derived Stem ceLLs in the Treatment of Patients With ST-Elevation myOcardial
Infarction - The APOLLO Trial
Randomized Clinical Trial to Study the Effect of Exercise
Training on the Function of HDL-Cholesterol Endothelial
Function Oxidative Stress and Regenerative Capacity of
Endothelial Progenitor Cells in Patients With Coronary Artery
Disease
Bypass Surgery and CD133 Marrow Cell Injection for Treatment of Ischemic Heart Failure
Stem Cell Therapy as Adjunct to Revascularization: STAR
2006
2007
2006
2006
2007
2006
2005
2007
2007
2007
USA
Israel
USA
Finland
Spain
Germany
Italy
Netherlands
Germany
Germany
2007 USA
Myocardial Regeneration Using Cardiac Stem Cells Harvested
From Right Atrial Appendages in Patients With Ischemic
Cardiomyopathy
Congestive Heart Failure Surgical Treatment With Autologous
Stem Cell Therapy
2009
2007
USA
Italy
Comparison of Efficiency of High Dose Atorvastatin and
Endothelial Progenitor-Capture Stents and Bare Metal Stents in
Reduction of Neointimal Formation in Patients With Non ST-
Segment Elevation Acute Coronary Syndromes
Single Center Prospective Randomized Partly-Double Blinded
Controlled Trial to Assess the Safety and Feasibility of
Intracoronary Cell Infusion Mobilized With G-CSF and
Darbepoetin and Their Effects on Improvement of Cardiac
Function in Patients With Myocardial Infarction: Myocardial
Regeneration and Angiogenesis in Myocardial Infarction With
G-CSF and Erythropoietin Mobilization and Intra-Coronary Cell
2007
2007
Poland
South Korea
Infusion –5-Combination Cytokine Therapy Trial
A Study of Combined Coronary Artery Bypass Grafting (CABG) 2006 Israel

NCT00526253
NCT00529932
NCT00536887
NCT00545610
NCT00548613
NCT00553774
NCT00555828
NCT00587990
NCT00615394
NCT00620048
NCT00626145
NCT00627068
NCT00629018
NCT00629096 and Blood-Borne Autologous Angiogenic Cell Precursors
Therapy in Patients With Congestive Heart Failure Due to
Ischemic Heart Disease
A Multicenter Study to Assess the Safety and Cardiovascular
Effects of Myocell™ Implantation by a Catheter Delivery System in Congestive Heart Failure Patients Post Myocardial
Infarction(s)
A Multi-Centre Double-Blind Randomised Placebo-Controlled
Trial Using CD133 Enriched Bone Marrow Cells Following
Primary Angioplasty for Acute Myocardial Infarction
Phase 4 Study of Atorvastatin 10mg vs 40mg in Follow-up CFR in AMI Patients
A 12-Month Follow-Up Study to Protocol 24779 (A Double-
Blind Prospective Randomized Placebo-Controlled Study to
Determine the Tolerability Efficacy Safety and Dose Range of
Intramyocardial Injections of G-CSF Mobilized Auto CD34+ Cells for Reduction of Angina Episodes in Patients With Refractory
Chronic Myocardial Ischemia [ACT34-CMI])
Phase I Study to Determine the Safety and Feasibility of the Use of a Combination Stem Cell Therapy in Patients With Acute
Myocardial Infarction
Effect of Cocoa Flavanols on Vascular Function in Optimally
Treated Coronary Artery Disease Patients: Interaction Between
Endothelial Progenitor Cells Reactivity of Micro- and
Macrocirculation
A Phase 1b2a Dose Escalation Study to Assess the Safety and
Feasibility of Transendocardial Delivery of 3 Different Doses of
Allogeneic Mesenchymal Precursor Cells (MPCs) in Subjects
With Recent Acute Myocardial Infarction
A Phase I/II Randomized Double-Blinded Placebo-Controlled
Study of the Safety and Efficacy of Intramyocardial Injection of
Autologous Human Mesenchymal Stem Cells (MSCs) in Patients
With Chronic Ischemic Left Ventricular Dysfunction Secondary to Myocardial Infarction (MI) Undergoing Cardiac Surgery for
Coronary Artery Bypass Grafting (CABG)
Autologous Transplantation of Bone Marrow Mononuclear
Stem-Cells by Mini-Thoracotomy in Dilated Cardiomyopathy -
Technique and Early Results
Injection of Autologous CD34+ Cells for Neovascularization and
Symptom Relief in Patients With Myocardial Ischemia and LVEF
< 40%
Long Term Functional Evaluation After Intracoronary Delivery of Autologous Bone Marrow Mononuclear Cells in Patients
With ST-Elevation Myocardial Infarction
The Role of Nitric Oxide Synthase in Circulating Progenitor Cell
Function
The Effects of Autologous Intracoronary Stem Cell
Transplantation In Patients With End-Stage Dilated
Cardiomyopathy
Effects of Intracoronary Infusion of Bone Marrow-Derived
Progenitor Cells on Myocardial Regeneration in Patients With
Non-Ischemic Dilated Cardiomyopathy
2007 USA
2007 Belgium
2005 South Korea
2007 USA
2007 USA
2007 USA
2008 USA
2007 USA
2004 Brazil
2008 USA
2003 China
2007 USA
2006 Slovenia
2008 Spain

NCT00684060
NCT00690209
NCT00694642
NCT00699686
NCT00701220
NCT00702936
NCT00711542
NCT00721045
NCT00725738
NCT00732953
NCT00743639
NCT00643981
NCT00644410
NCT00650143
NCT00669227
NCT00684021
Phase I Study to See if a of A Combination Stem Cell Therapy is
Safe and Feasible for the Treatment of Severe Coronary
Ischemia
A Single Centre Randomised Controlled Study of the Effect of
NOGA-Guided Direct Intramyocardial Injection of Mesenchymal
Stromal Cells on the Development of New Myocardium and
Blood Vessels in Patients With Heart Failure
Safety and Efficacy of Sitagliptin Plus Granulocyte-colony
Stimulating Factor in Patients Suffering From Acute Myocardial
Infarction
Intracoronary Stem Cell Therapy in Patients With Acute
Myocardial Infarction - A Randomized Double-Blind Placebo
Controlled Trial (SCAMI)
Transplantation in Myocardial Infarction Evaluation (TIME)
Protocol: A Phase II Randomized Controlled Double-Blind Trial
Evaluating the Effect of Timing on the Administration of Bone
Marrow Mononuclear Cells (BMMNCs) Versus Placebo in
Patients With Acute Myocardial Infarction
A Phase II Randomized Controlled Double-Blind Pilot Trial
Evaluating the Safety and Effect of Administration of Bone
Marrow Mononuclear Cells Two to Three Weeks Following
Acute Myocardial Infarction
Efficacy of Surgical Coronary Revascularization Associated With
Stem Cells Injection in Patients With Severe Chronic Ischemic
Heart Disease With Residual Viability A Prospective Controlled
Pilot Trial
Safety and Efficacy of Transendocardial Injection of Autologous
Endothelial Progenitor Cell CD 133 for Therapeutics
Angiogenesis
Effects of Adding Basal Insulin on Endothelial Progenitor Cell
Levels in Poorly-Controlled Type 2 Diabetic Patients With
Cardiovascular Disease A Randomized Cross-Over Study
Comparing Insulin Detemir and Glargine
Statin Induced Augmentation of Circulating Endothelial
Progenitor Cells and Myocardial Viability in Patients With
Ischemic and Nonischemic Cardiomyopathy
Telmisartan vs Ramipril for Reduction of Inflammation and
Recruitment of Endothelial Progenitor Cells After Acute
Coronary Syndrome
Reinfusion of Enriched Progenitor Cells And Infarct Remodeling in Acute Coronary Syndrome: REPAIR - ACS
A Phase II Dose-Escalation Study to Assess the Feasibility and
Safety of Transendocardial Delivery of Three Different Doses of
Allogeneic Mesenchymal Precursor Cells (MPCs)in Subjects
With Heart Failure
Intracoronary Autologous Stem Cell Transplantation in ST
Elevation Myocardial Infarction: TRACIA Study
Prevention of Restenosis After Genous Stent Implantation
Using a Paclitaxel Eluting Balloon in Coronary Arteries - a
Randomized Clinical Trial
Autologous Transplantation of Bone Marrow Mononuclear
Stem-Cells for Dilated Cardiomyopathy: Randomized Clinical
2008 USA
2008 Denmark
2008 Germany
2005 Germany
2008 USA
2008 USA
2008 France
2008 Spain
2008 Italy
2007 USA
2007 Italy
2008 Germany
2008 USA
2008 Mexico
2009 Germany
2005 Brazil

NCT00747708
NCT00756756
NCT00765453
NCT00768066
NCT00790764
NCT00800657
NCT00824005
NCT00841958
NCT00869024
NCT00874354
NCT00877903
NCT00883727
NCT00893360
NCT00911339
Trial
Randomised Control Trial to Compare the Effects of G-CSF and
Autologous Bone Marrow Progenitor Cells Infusion on the
Quality of Life and Left Ventricular Function in Patients With
Heart Failure Secondary to Ischaemic Heart Disease
The Effect of Granulocyte Colony Stimulating Factor (G-CSF) on
Myocardial Function After Acute Anterior Myocardial Infarction a Prospective Double Blind Randomized Placebo Controlled
Study
Randomised Controlled Clinical Trial of the Use of Autologous
Bone Marrow Derived Progenitor Cells to Salvage Myocardium in Patients With Acute Anterior Myocardial Infarction
A Phase I/II Randomized Double-Blinded Placebo-Controlled
Study of the Safety and Efficacy of Transendocardial Injection of Autologous Human Cells (Bone Marrow or Mesenchymal) in
Patients With Chronic Ischemic Left Ventricular Dysfunction and Heart Failure Secondary to Myocardial Infarction
Phase II Study for the Transfer of Bone Marrow-Derived
Mononuclear and Mesenchymal StemCells Into the
Myocardium for the Treatment of Severe Coronary Ischemia
Stem-Cells and Heart Failure in Several Ethiologies Alternative
Indication With Cardiac Resynchronization
Randomized Controlled Phase II Double-Blind Trial of
Intramyocardial Injection of Autologous Bone Marrow
Mononuclear Cells Under Electromechanical Guidance for
Patients With Chronic Ischemic Heart Disease and Left
Ventricular Dysfunction
Efficacy of the Endocardial Stem Cells Implantation in Ischemic
Heart Failure Patients
Intramyocardial Delivery of Bone Marrow Derived
Mononuclear Cells in Patients With Severe Left Ventricular
Dysfunction and Left Ventricular Assist Device Support
REVITALIZE: Randomized Evaluation of Intracoronary
Transplantation of Bone Marrow Stem Cells in Myocardial
Infarction
A Phase II Multi-center Randomized Double-blind Placebocontrolled Study to Evaluate the Safety and Efficacy of
PROCHYMAL® (Ex Vivo Cultured Adult Human Mesenchymal
Stem Cells) Intravenous Infusion Following Acute Myocardial
Infarction
A Randomized Double Blind Multicentric Placebo Controlled
Single Dose Phase - I/II Study Assessing the Safety and Efficacy of Intravenous ex Vivo Cultured Adult Allogenic Mesenchymal
Stem Cells in Patients With st Elevated Acute Myocardial
Infarction (Stemi)
A Phase I Randomized Dose Escalation Study of the Safety and
Efficacy of Intracoronary Delivery of Cardiosphere-Derived
Stem Cells in Patients With Ischemic Left Ventricular
Dysfunction and a Recent Myocardial Infarction
Mobilization of Endothelial Progenitor Cells Induced by
Atorvastatin in Patients With Stable Coronary Artery Disease
Treated With Anti-CD 34 Antibodies Coated Stents
2005 UK
2007 Iran
2008 UK
2008 USA
2008 USA
2008 Brazil
2009 USA
2007 Russia
2009 USA
2005 USA
2009 USA
2009 India
2009 USA
2009 Italy

NCT00927784
NCT00936234
NCT00937443
NCT00939042
NCT00950274
NCT00979758
NCT00981006
NCT00984178
NCT01004406
NCT01030367
NCT01049867
NCT01061580
NCT01067339
NCT01076920
NCT01078363
NCT01087996
NCT01096875
NCT01102699
The Effect of Intramyocardial Injection of Mesenchymal
Precursor Cells on Myocardial Function in LVAD Bridge to
Transplant Patients
Functional Improvement of Progenitor Cells and Endothelial
Function by Vildagliptin in Diabetes Mellitus (FINNjA-DM)
Effectiveness of a Walking Program Modulating
Cardioreparative Factors in Heart Failure
Percutaneous Intramyocardial Cell Therapy After Acute
Myocardial Infarction Using Bone Marrow Mononuclear Cells
Intramyocardial Transplantation of Bone Marrow Stem Cells for
Improvement of Post-infarct Myocardial Regeneration in
Addition to CABG Surgery: a Controlled Prospective
Randomized Double Blinded Multicenter Trial (PERFECT)
Strengthening Transplantation Effects of Bone Marrow
Mononuclear Cells With Atorvastatin in Myocardial Infarction
Hybrid Biotherapy Involving Autologous Human Cardiac Stem
Cell Transplantation Combined With the Controlled Release of bFGF Using a Gelatin Hydrogel Sheet to Treat Severe Refractory
Heart Failure With Chronic Ischemic Cardiomyopathy
Randomized Trial Comparing Intracoronary Delivery of Bone
Marrow-derived Stem Cells Versus Stem Cell Mobilisation With
GCSF a Combination of Both Therapies and Conventional
Treatment in Patients With Reperfused Acute Myocardial
Infarction
Plaque Regression and Progenitor Cell Mobilization With
Intensive Lipid Elimination Regimen (PREMIER)
Pilot Study of Organic Nitrates on Endothelial Progenitor Cells and Endothelial Function in Patients With Coronary Artery
Disease
Phase 1-2 Study of Intracoronary Infusion of CD133+
Endothelial Precursor Cells for Patients With Coronary Heart
Disease in Selected Obstructed Artery
Dose Response Study of Autologous Concentrated Bone
Marrow Nucleated Cell Therapy for Congestive Heart Failure
Patients Undergoing Treatment With Coronary Artery Bypass
Grafting (CABG) Surgery
Lp-PLA2 Progenitor Cells and Coronary Atherosclerosis in
Humans AIM III
Administration of Mesenchymal Stem Cells in Patients With
Chronic Ischemic Cardiomyopathy
ACE Inhibition and Cardiac AlloGraft Vasculopathy
A Phase I/II Randomized Pilot Study of the Comparative Safety and Efficacy of Transendocardial Injection of Autologous
Mesenchymal Stem Cells Versus Allogeneic Mesenchymal Stem
Cells in Patients With Chronic Ischemic Left Ventricular
Dysfunction Secondary to Myocardial Infarction
Assessment of the Effects of Atorvastatin on Endothelial
Progenitor Cells After Coronary ByPass Surgery A Randomized
Controlled Trial
Bone Marrow Responsiveness to Pharmacologic Mobilization of Progenitor Cells in Type 2 Diabetic and Non-diabetic Patients
2009 USA
2009 Germany
2009 USA
2009 Germany
2009 Germany
2009 China
2009 Japan
2005 Spain
2010 USA
2007 Germany
2009 Mexico
2010 India
2010 USA
2009 France
2009 USA
2010 USA
2010 Turkey
2010 Italy

NCT01167751
NCT01176578
NCT01187654
NCT01214499
NCT01216995
NCT01219452
NCT01234181
NCT01267331
NCT01272895
NCT01274234
NTR1553
Autologous bone marrow derived AC 133+ and mono nuclear cells in-patient with acute myocardial infarction during coronary artery bypass grafting (CABG) a randomized phase III clinical trial
Effects of exercise on the regulation of EPCs in obesity insulin resistance and type 2 diabetes
Comparison the therapeutic outcomes of bone marrow derived ac 133+ and mono-nuclear cells (mnc) implantation in patient with acute myocardial infarction underwent pci procedure
Prospective controlled and randomized clinical trial on cardiac cell regeneration with laser and autologous bone marrow stem cells in patients with coronary disease and refractory angina
Safety and efficacy of ADRCs delivered via the intracoronary route in the treatment of patients with st-elevation acute myocardial infarction - the advance study
Effects of intramuscular injection of umbilical cord mesenchymal stem cell on the ventricular function of children with idiopathic dilated cardiomyopathy
Clinical study of hypoxia-stressed bone marrow mononuclear cell intracoronary transplantation in myocardial infarction and other heart diseases.
A prospective randomized placebo-controlled study of intramyocardial injection of autologous bone-marrow mononuclear cells in patients with severe chronic ischemic heart disease undergoing coronary bypass surgery
Evaluation of endothelial progenitor cell (EPC) capturing
(genous) stent after coronary stenting utilizing optical coherence tomography (oct) the ego study
Evaluation of neointimal healing of endothelial progenitor cell capturing sirolimus-eluting (combo) stent by optical coherence tomography the ego-combo pilot study
Mesenchymal stem cells after acute myocardial infarction.
Peripheral Vascular System Diseases
2008
2011
2009
2010
2011
2010
2010
2010
2010
2010
2006
Iran
USA
Iran
Spain
Netherlands
China
China
China
China
China
Netherlands
ChiCTR-TRC-10000912 Autologous transplantation of bone marrow mesenchymal stem cells for diabetic foot
CTRI/2009/091/000954 Safety and efficacy of patient`s own stem cells in prevention of amputation in patients with chronic critical limb due to obstruction of blood flow in arteries of the affected limb(s).
2004
2009
China
India
CTRI/2010/091/000565 A clinical trial to evaluate the effect of bone marrow derived stem cell in diseases Limb Ischemia
JPRN-JMA-IIA00022
2010 India stem cell transplantation for vascular regeneration in the legs 2008 Japan
NCT00113243 2004 USA
NCT00166036
NCT00221143
NCT00246883
Phase I Study of Stem Cell Mediated Angiogenesis for Limb
Threatening Ischemia
Effect of Statins on Oxidative Stress and Endothelial Progenitor
Cells: Comparison of Atorvastatin With Pravastatin
Phase I II Clinical Trial Regarding Vascular Regeneration
Therapy by Transplantation of Autologous Peripheral Blood
Endothelial Progenitor Cells (CD34+ Cells) in No-Option
Patients With Chronic Critical Limb Ischemia
Effect of Regular Exercise on Vascular Function and
Cardiovascular Risk in a Sedentary Work Force: The NHLBI Keep
2004
2003
2005
USA
Japan
USA

NCT00411840
NCT00434616
NCT00442143
NCT00469027
NCT00488020
NCT00518401
NCT00523393
NCT00523731
NCT00595257
NCT00257413
NCT00278512
NCT00278603
NCT00282646
NCT00306085
NCT00311805
NCT00371371
NCT00372346
NCT00392509 the Beat Program
Safety and Efficacy Study of Transplantation of EPCs to Treat
Idiopathic Pulmonary Arterial Hypertension
High Dose Immune Suppression With Hematopoietic Stem Cell
Support in Refractory Vasculitis Necrotizing Vasculitis
Neurovascular Behcet's Disease and Sjogren's Syndrome
Hematopoietic Stem Cell Injection for Peripheral Vascular
Disease: Induction of Neoangiogenesis A Phase I Study
(Intraarterial Progenitor Cell Transplantation of Bone Marrow
Mononuclear Cells for Induction of Neovascularization in
Patients With Peripheral Arterial Occlusive Disease)
Autologous Bone Marrow Cell Treatment in Patients With
Peripheral Atherosclerosis
Injection of Autologous CD34-Positive Stem Cells for
Neovascularization and Symptom Relief in Patients With Severe
Intermittent Claudication
Intra-Arterial Infusion of Autologous Bone Marrow
Mononuclear Cells in Patients With Chronic Critical Limb
Ischemia: a Randomized Placebo-Controlled Clinical Trial
Safety and Efficacy Study of Transplantation of EPCs to Treat
Idiopathic Pulmonary Arterial Hypertension
A Phase I-II Randomized Autologous Bone Marrow Derived
Aldehyde Dehydrogenase-Bright (ALDHbr) Cells Against
Unfractionated Autologous Mononuclear Bone Marrow in
Patients With Rutherford 4 or 5 Peripheral Arterial Occlusive
Disease
Transplantation of Autologous Mononuclear Bone Marrow
Stem Cells in Patients With Peripheral Arterial Disease (TAM-
PAD Study)
Security and Effectiveness of Autologous Bone Marrow Stem
Cell Transplantation to Avoid Amputations in Patients With
Limb-Threatening Ischemia: A Multicentric Randomized
Placebo-Controlled Double-Blind Study
Treatment of Severe Limb Ischemia With Autologous
Bonemarrow Derived Mononuclear Cells
Phase I Trial to Establish Safety of Autologous Progenitor Cell-
Based Gene Therapy Delivery of heNOS in Patients With Severe
Pulmonary Arterial Hypertension(PAH)Refractory to
Conventional Treatment
The Use of Autogenous Adult Stem Cells in the Treatment of
Critical Ischemia
Phase I Study of A Combination Stem Cell Therapy is Safe and
Feasible in the Development of Mature Stable Vessels in
Ischemic Limbs
Prospective Influence of Bedtime Insulin Glargine on
Mobilization and Function of Endothelial Progenitor Cells in
Patients With Type 2 Diabetes: a Partially Double-Blind
Randomized Three-Arm Unicenter Study
A Study of Blood-Borne Autologous Angiogenic Cells Precursors
Therapy in Patients With Critical Limb Ischemia
Feasibility Study of the Safety and Activity of Autologous Bone
Marrow Aspirate Concentrate (BMAC) for the Treatment of
China
2003 USA
2004 USA
2005 Germany
2005 Italy
2006 USA
2006 Netherlands
2006 China
2006 USA
2004 Germany
2007 Germany
2007 Denmark
2006 Canada
2006 Brazil
2007 USA
2007 Germany
2006 Israel
2007 India

NCT00913900
NCT00919516
NCT00922389
NCT00926081
NCT00955669
NCT01019681
NCT01041287
NCT01041417
NCT01065337
NCT00616980
NCT00641836
NCT00677404
NCT00721006
NCT00753025
NCT00770835
NCT00797056
NCT00872326
NCT00883870
Non Reconstructable Critical Limb Ischemia Due to Peripheral
Arterial Occlusive Disease
Injection of Autologous CD34-Positive Cells for Improved
Symptomatic Relief and Ischemic Wound Healing in Subjects
With Moderate or High-Risk Critical Limb Ischemia
One-Year Follow-Up of Autologous Endothelial Progenitor Cells
Transplantation in Patients With Idiopathic Pulmonary Arterial
Hypertension
Evaluation of Clinical Outcome in Advanced Chronic Lower
Limb Ischemia by Stem Cell Transplantation With or Without
(Granulocyte-Colony Stimulation Factor) G-CSF Injection
Phase II SafetyEfficacy Study of A Combination Stem Cell
Therapy That Develops Mature Stable Vessel Formation in
Ischemic Limbs
Randomized Double Blind Placebo-Controlled Research Of
Treatment Efficiency For Patients With Lower Extremity
Arteriosclerosis Obliterans By Autologous Transplantation Of
Bone Marrow Progenitor Cells
Effects of Pioglitazone on Endothelial Progenitor Cells in Type 2
Diabetic Patients With Vascular Complications - The SPLENDOR
Study
Pilot Study of Stem Cell Mobilization by G-CSF to Treat Severe
Peripheral Artery Disease (STEMPAD Trial)
Phase I/II Study of Regenerative Cell Therapy in Treating
Diabetic Patients With Critical Limb Ischemia
A Randomized Double Blind Multicentric Placebo Controlled
Single Dose Phase – I/II Study Assessing the Safety and Efficacy of Intramuscular ex Vivo Cultured Adult Allogenic
Mesenchymal Stem Cells in Patients With Critical Limb
Ischemia (CLI)
Stem Cell Revascularization in Patients With Critical Limb
Ischemia
Use of Autologous Bone-Marrow Mononuclear Cell
Implantation Therapy as a Limb Salvage Procedure in Patients
With Moderate to Severe Peripheral Arterial Disease
A Randomized Controlled Parallel Design Safety and Efficacy
Study of Granulocyte Colony Stimulating Factor Mobilized
Autologous Peripheral Blood Mononuclear Cell Therapy in
Subjects With Diabetic Limb Ischemia
Exercise Training Versus Best Medical Treatment Only in
Peripheral Artery Disease
Autologous Transplantation of Bone Marrow Mesenchymal
Stem Cells on Diabetic Foot
Umbilical Cord Blood Stem Cell Injection for Critical Limb
Ischemia
Effect of Nebivolol on Oxidative Stress and Endothelial
Progenitor Cells in Subjects With Hypertension
Granulocyte-Macrophage Stimulating Factor (GM-CSF) and
Mobilization of Progenitor Cells in Peripheral Arterial Disease:
A Phase II Randomized Study
Study on Induced Wound Healing Through Application of
Expanded Autologous Bone Marrow Stem Cells in Diabetic
2007 USA
2005 China
2008 Iran
2008 USA
2006 Russia
2009 Italy
2008 USA
2007 Spain
2009 India
2009 USA
2007 USA
2009 India
2007 Austria
2009 China
2009 USA
2009 USA
2009 USA
2005 Germany

NCT01067326
NCT01079403
NCT01212653
NCT01216865
NCT01232673
NCT01245335
NCT01257776
NCT01270139
NTR997
Patients With Ischemia-induced Chronic Tissue Ulcers Affecting the Lower Limbs
The Effect of Tekturna on Endothelial Function and Endothelial
Progenitor Cells in Patients With Early Atherosclerosis
Phase 12 Clinical Trial of Regenerative Cell Therapy With
Autologous Mesenchymal Stem Cells From Adipose Tissue in
Diabetic Patients With Chronic Critical Ischemic Syndrome of
Lower Limbs
Effect of anti-tnf(alpha)treatment on circulating endothelial progenitor cells (EPCs) and vascular stiffness in as
Safety and efficacy of umbilical cord mesenchymal stem cells injection for diabetic foot
Autologous bone marrow stem cell transfer in patients with chronical critical limb ischemia and diabetic foot
Pivotal study of the safety and effectiveness of autologous bone marrow aspirate concentrate (bmac) for the treatment of critical limb ischemia due to peripheral arterial disease
Phase i-ii study of the use of human adipose derived mesenchymal stem cells as regenerative therapy in diabetic patients with critical limb ischemia
Silica-gold nanoparticles and mesenchymal stem cells versus composite ferro-magnetic approach for management of atherosclerotic plaque and artery remodeling
Intramuscular or combined intramuscular/intra-arterial administration of bone marrow mononuclear cells in patients with advanced limb ischemia.
2010 USA
2009 Spain
2010 China
2011 China
2008 Czech
Republic
2011 USA
2010 Spain
2010 Russia
2004 Netherlands
Clinical Trial ID* Official Title Start
Year
Country**
Type 1 Diabetes Mellitus
ChiCTR-TNC-10000986 Umbilical cord mesenchymal stem cell transplantation for treatment of type 1 diabetes
IRCT138810271414N8 Mesenchymal stem cell transplantation in the treatment of type 1 diabetic patients
IRCT138811071414N10 Control of diabetes type one with fetal Hematopoietic stem cells allotransplantation in type 1 diabetic patients
NCT00239148 A Randomized Double-Blind Controlled Clinical Trial to Evaluate
NCT00315133 the Safety Tolerability Pharmacokinetic Profile and Effects of
Repeated Subcutaneous Doses of E1 in Combination With G1 in
Type 1 Diabetes
Autologous Hematopoietic Stem Cell Transplantation for Early
Onset Type 1 Diabetes Mellitus- a Phase I/II Study
2010 China
2010 Iran
2008 Iran
2005 USA
2003 Brazil

NCT00646724
NCT00690066
NCT00703599
NCT00788827
NCT00807651
NCT00873925
NCT00971503
NCT00989547
NCT01068951
NCT01121029
NCT01143168
NCT01157403
NCT01219465
NCT01322789
Cotransplantation of Islet and Mesenchymal Stem Cell in Type
1 Diabetic Patients
A Phase II Multicenter Randomized Double-Blind Placebo-
Controlled Study to Evaluate the Safety and Efficacy of
PROCHYMAL® (Ex Vivo Cultured Adult Human Mesenchymal
Stem Cells) for the Treatment of Recently Diagnosed Type 1
Diabetes Mellitus (T1DM)
Phase III Study of Intravenous Administration of Activated
Autologous Adipose-Derived Stromal Vascular Fraction in
Patients With Type 1 Diabetes
A Phase I Safety and Tolerability Study Following the Infusion of
Autologous Expanded Progeny of an Adult CD34+ Stem Cell
Subset (InsulinCytes) to Patients With Type I Diabetes Mellitus and a Successful Renal Transplant
Safety and Efficacy Study of Autologous Nonmyeloablative
Hematopoietic Stem Cell Transplantation for Early Onset Type
1 Diabetes-a Phase II Study
Transfusion of Autologous Umbilical Cord Blood Plus Vitamin D and Omega 3 Fatty Acids to Preserve Beta Cell Function in
Children With Recent Onset Type 1 Diabetes - A Pilot Study
Safety and Efficacy of Arterial Delivery of Autologous Bone
Marrow Cells in the Treatment of Insulin-Dependent Diabetes
Transfusion of Autologous Umbilical Cord Blood to Reverse
Hyperglycemia in Children With Type 1 Diabetes - A Pilot Study
Open Study to Evaluate the Safety and Efficacy of Autologous
Mesenchymal Stem Cells in Treatment of Recently Diagnosed
Patients With Type 1 Diabetes Mellitus
Autologous Hematopoietic Stem Cell Transplantation in Type 1
Diabetes Mellitus
A Pilot Study on Transplantation Therapy Using Autologous
Bone Marrow Mononuclear Cells and Umbilical Cord
Mesenchymal Stem Cells in Patients With Type 1 Diabetes
Mellitus
Autologous transplantation of mesenchymal stem cells for treatment of patients with onset of type 1 diabetes
Safety and efficacy of umbilical cord mesenchymal stem cells infusion for initial type 1 diabetes
Safety and efficacy of mesenchymal stem cells in newlydiagnosed type 1 diabetic patients
Type 2 Diabetes Mellitus
ChiCTR-TNC-10000985 Umbilical cord mesenchymal stem cell transplantation for treatment of type2 diabetes
NCT00239187 A Randomized Double-Blind Placebo-Controlled Clinical Trial to
Evaluate the Safety Tolerability Pharmacokinetics and Clinical
NCT00644241
NCT00703612
Response of Repeated Subcutaneous Doses of E1 in
Combination With G1 in Patients With Type 2 Diabetes
Efficacy Of Autologous Bone Marrow Derived Stem Cell
Transplantation In Patients With Type 2 Diabetes Mellitus
Phase I/II Study of Intravenous Administration of Activated
Autologous Adipose-Derived Stromal Vascular Fraction in
Patients With Type 2 Diabetes
2008 China
2008 USA
2007 Philippines
2008 UK
2008 China
2009 USA
2009 Chile
n/a Germany
2010 Sweden
2010 Mexico
2010 China
2010 China
2010 China
2008 Brazil
2010 China
2005 USA
2008 India
2007 Philippines

NCT00767260 Autologous Mesenchymal Stem Cell and Bone Marrow Stem
Cell Infusion Combined With Hyperbaric Oxygen Therapy in
Type 2 Diabetes Mellitus
NCT01065298
NCT01142050
Efficacy Of Autologous Bone Marrow Derived Stem Cell
Transplantation In Patients With Type 2 Diabetes Mellitus
A Open Labeled and Self Controlled SafetyEfficacy Assessed
Pilot Study on Transplantation Therapy Using Bone Marrow
Mesenchymal Stem Cells for Insulin Resistance of Type 2
Diabetes Mellitus
Both Types 1 and 2 Diabetes Mellitus
2008 China
2009 India
2010 China
NCT00465478 Autologous Bone Marrow Mononuclear Cell Transplantation in
Treating Patients With Type 1 or 2 Diabetes Mellitus-a Phase
1/2 Study
2006 China