Principal Investigator/Program Director (Last, First, Middle):
BIOGRAPHICAL SKETCH
Provide the following information for the key personnel and other significant contributors in the order listed on Form Page 2.
Follow this format for each person. DO NOT EXCEED FOUR PAGES.
NAME: Anthony
J. Durkin
POSITION TITLE
Associate Professor in Residence
eRA COMMONS USER NAME
AJDurkin
EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.)
INSTITUTION AND LOCATION
Lamar University, Beaumont, TX
University of North Texas, Denton, TX
University of Texas, Austin
Electro-optics branch/CDRH/ Food and Drug
Administration, Rockville MD
Beckman Laser Institute, Univ. of California, Irvine
DEGREE
(if applicable)
YEAR(s)
B.S.
M.S.
Ph.D.
NRC Post-doc
1985
1988
1995
1995-1997
Fellow
2001-2003
FIELD OF STUDY
Physics
Condensed Matter Physics
Biomedical Engineering
Optical Spectroscopy and
Chemometrics
NIR tissue spectroscopy
A. Personal Statement
My research program focuses on development and application of quantitative, in-vivo optical spectroscopy and
imaging techniques that can be used to non-invasively access functional and structural information in
superficial tissue volumes. Currently we are engaged in applying these technologies to clinically compelling
problems such as early identification of failure in reconstructive skin flaps, non-invasive burn wound severity
assessment and characterization of skin and skin cancer. Over the past three years I have collaborated with
Modulating Imaging Inc. and Kristen Kelly (MD, Dermatology) to develop a noninvasive, optical imaging based
method for quantifying the optical properties and tissue oxygen saturation in basal cell carcinoma with the
objective of developing a means for better understanding dosimetry in photodynamic therapy of skin cancer.
Prior to my arrival at the Beckman Laser Institute, I was the Director of Bioscience at Candela Corporation,
where I worked for three years on a fluorescence imaging based approach for demarcating the margin of
nonmelanoma skin cancer with the objective of developing an inexpensive alternative to Mohs surgery. This
collective experience provides me with expertise and perspective with which to Co-direct the Skin Cancer
Disease Oriented Team within the CFCCC.
B. Positions and Honors.
Positions and Employment:
1988 - 1989
Research Assistant, Two Photon Magneto-Optical Characterization Group, Center for Applied Quantum
Electronics (CAQE), University of North Texas , Denton TX, C.L. Littler Advisor
1989-1990
Research Assistant, Electron Microscopy Group, Center for Materials Characterization (CMC),
University of North Texas, Denton TX Russell Pinizotto Advisor
1991-1995
Research Assistant, Biomedical Engineering Optical Spectroscopy Group, University of Texas,
Austin TX Rebecca Richards-Kortum Advisor
1995-1997
Postdoctoral Research Fellow, National Academy of Sciences/National Research Council (NRC)
Research Fellow: Electro-Optics Branch, Center for Devices and Radiological Health/Food and Drug
Administration, Rockville MD.
1997
Visiting Scientist, Electro-Optics Branch, Center for Devices and Radiological Health/Food and Drug
Administration, Rockville MD
1998-2001
Director of Bioscience, Candela Corporation. Wayland, MA
2001- 2003
Postdoctoral Research Fellow; Beckman Fellow, Beckman Laser Institute, University of California, Irvine
2003-2010
Assistant Professor in Residence, Beckman Laser Institute, University of California, Irvine
2008-present Co-Director, Wide Field Functional Imaging, Laser and Medical Microbeam Program (NIH P41 Center)
2010 - present Associate Professor in Residence, Beckman Laser Institute, University of California, Irvine
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Honors:
1995-1997
2001-2003
National Research Council (NRC) Research Fellow, Center for Devices and Radiological Health/Food
and Drug Administration, Rockville MD
Arnold & Mabel Beckman Fellowship, Beckman Laser Institute, Irvine, CA
C. Selected peer-reviewed publications most relevant to the current application
1. “In-vivo fluorescence spectroscopy of Non-Melanoma Skin Cancer”, Lorenzo Brancaleon, Anthony J. Durkin,
John H. Tu, Gregg Menaker, Jerome D. Fallon, Nikiforos Kollias, Photochemistry and Photobiology 2001 73(2):
178-183.
2. “Determination of Optical Properties of Superficial Volumes of Layered Tissue Phantoms,” Sheng-Hao Tseng,
Carole Hayakawa, Jerome Spanier, Anthony J. Durkin, IEEE Trans Biomed Eng. 2008 Jan; 55(1):335-9.
3. “In-vivo Determination of Skin Optical Properties using Diffuse Optical Spectroscopy”, Sheng-Hao Tseng,
Alexander Grant, Anthony J. Durkin, J. Biomed. Opt. Vol. 13, 014016 (Jan. 14, 2008)
4. “Quantitative Mapping of Turbid Media Optical Properties using Modulated Imaging.” D. J. Cuccia, F.
Bevilacqua, A. J. Durkin, F. Ayers, B. J. Tromberg, Journal of Biomedical Optics, Vol. 14, 024012 (2009);
DOI:10.1117/1.3088140 Published 3 April 2009
5. Wide-field Spatial Mapping of in-vivo Tattoo Skin Optical Properties using Modulated Imaging, Frederick Ayers,
David J. Cuccia, Kristen Kelly, Anthony J. Durkin, Journal of Lasers in Surgery and Medicine. 2009;41(6):44253. PMCID: PMC2745269
6. “Determination of optical properties of turbid media spanning visible and near infrared regimes via Spatially
Modulated Quantitative Spectroscopy (SMoQS)”, Rolf B Saager, David J Cuccia, Anthony J Durkin, J.
Biomed. Opt., Vol. 15, 017012 (2010); doi:10.1117/1.3299322
7. “Early Detection of Complete Vascular Occlusion in a Pedicle Flap Model using Quantitative Spectral
Imaging”. Michael R. Pharaon, MD, Thomas Scholz, MD, Scott Bogdanoff, David Cuccia, PhD, Anthony J.
Durkin, PhD, David D Hoyt, MD, FACS, Gregory R.D. Evans, MD, FACS, Journal of Plastic and
Reconstructive Surgery. December 2010 - Volume 126 - Issue 6 - pp 1924-1935
doi:10.1097/PRS.0b013e3181f447ac
8. “Postoperative Quantitative Assessment of Reconstructive Tissue Status in Cutaneous Flap Model using Spatial
Frequency Domain Imaging.” Amr Yafi, Thomas S Vetter, Michael R Pharaon, Thomas Scholz, Sarin Patel, Rolf
B Saager, David J Cuccia, Gregory R Evans, Anthony J Durkin, Plastic & Reconstructive Surgery. 127(1):117130, January 2011. doi: 10.1097/PRS.0b013e3181f959cc
9. Method for depth-resolved quantitation of optical properties in layered media using Spatially Modulated
Quantitative Spectroscopy (SMoQS), Rolf B Saager, Alex Truong, David J Cuccia, Anthony J.
Durkin, SPIE Journal of Biomedical Optics, 16, 077002 (Jul 07, 2011); doi:10.1117/1.3597621 PMID:
21806282
10. First-in-Human Pilot Study of a Spatial Frequency Domain Oxygenation Imaging System, Sylvain
Gioux , Amaan Mazhar , Bernard T. Lee , David J Cuccia , Alan Stockdale , Rafiou Oketokoun ,
Yoshimoto Ashitate , Edward Kelly , Maxwell Weinmann , Nicholas James Durr , Lorissa A. Moffitt ,
Anthony J Durkin, Bruce J. Tromberg , John V. Frangioni, SPIE Journal of Biomedical Optics, 2011
Aug;16(8):086015. PMID:21895327
11. Quantitative fluorescence imaging of Protoporphyrin IX though determination of tissue optical
properties in the Spatial Frequency Domain, Rolf B Saager, David J Cuccia, Steve Saggese, Kristen M
Kelly, Anthony J Durkin, Submitted to SPIE Journal of Biomedical Optics Letters, In Press, Accepted
Nov. 2011
D. Research Support
Active
Project: Assessment of Reconstructive Surgical Flaps using Spatially Resolved Tissue Oximager
NIH Phase II STTR: Aug. 5, 2010
Duration: Aug 2011 – July 2013
2.4 cal mo
Sponsor: NIH/NIGMS
Budget (direct costs, to UCI): $498,000
Role: AJ Durkin PI: I am responsible for design and execution of in-vivo validation studies of this
technology and comparing it’s performance to at least one FDA cleared competing technology. I
coordinate Greg Evans (MD, Chief of Plastic Surgery), John Lakey (Director of Surgical Research, Large
Animal facility, UCIMC) in addition to a post-doc and a medical resident both of whom I directly supervise.
I am responsible for overall scientific direction and data interpretation as well as reporting.
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One promising technology for measuring local tissue oxygenation in-vivo is Modulated Imaging (MI). MI is a noncontact imaging approach that enables rapid quantitative determination of the optical properties and in-vivo
concentrations of chromophores over a wide field-of-view. The central aim of the proposed Phase II research is to
further the development of Modulated Imaging and to assess the viability of this as a means to determine status
of tissue reconstruction flaps.
Project: Advanced Optical Technologies for Defense Trauma and Critical Care – Advanced Surgical Camera
Military Photomedicine Program
07/01/11-06/30/12
2.5 cal mo
Air Force Office of Scientific Research $200,000 direct
Role: AJ Durkin PI on Advanced Surgical Camera: I am responsible for oversight of the design,
construction and deployment of an Advanced Surgical Camera based on spatial frequency domain
imaging, the modeling efforts associated with this, testing and validation as well as the deployment of
this device into appropriate projects, both clinical and preclinical. In addition, I am responsible for
identifying appropriate collaborations, regularly reviewing the data, directing revision of the instrument
as needed, and annual reporting to the AFOSR. Finally, I am responsible for writing the 3 year renewal of
this grant in spring 2012.
The goal of my sub-section of this proposal to is to develop and test a Spatial Frequency Domain Imaging system
within the context of trauma, reconstructive surgery and burn wound severity assessment.
Project: Spatially Modulated Quantitative Spectroscopy for Dermatologic Application
1R03EB012194-01(Durkin)
07/15/10 – 06/14/12
0.6 cal mo
NIH – NIBIB
$100,000 total direct
AJ Durkin, PI; I direct the design and construction of a new device for quantifying skin constituent, which
will ultimately be deployed to the Melanoma Center. In addition, I am responsible for directing the
modeling efforts of the post-doc working on this project and all aspects of reporting.
The central goal of this proposed research is to design, test and deploy a novel, compact, clinically robust
measurement platform capable of determining intrinsic optical properties and chromophore concentrations of invivo skin across a broad spectral range (melanoma focus).
Project:The Development of a low-cost, quantitative skin imaging camera
1R43RR030696-01 (Cuccia, Durkin)
06/01/10 – 05/30/12
1.2 cal mo
NIH/NCRR
$110,187 total to UCI
AJ Durkin, PI; I am responsible for providing specifications for the system design related to skin imaging
and am responsible for directing the efforts to characterize the performance of the resulting system and
reporting the results of these efforts.
The broad goal of this proposal is to take Modulated Imaging technology and develop a handheld camera akin to
a digital-SLR.
Project: Metal nanopartical mediated imaging, targeting, and treatment of cancer
R01 CA132032-01 (Tunnell, U Texas, Austin)
04/01/08-03/31/13
0.48 cal mo
NIH/NIBIB
$8,500 to UCI
AJ Durkin, Co-investigator: I am responsible for providing expertise on the design of a spatial
frequency domain imaging system for use at UT Austin to quantify nanoparticles in tumors.
Metal nanoparticles (NP) are a new class of materials with unique optical and molecular properties
suitable as in vivo agents for the combining of these three components. The proposed project
represents a long term interdisciplinary effort to develop a technology for cancer imaging, targeting, and
treatment using metal nanoparticles as the mediator. The proposed studies will develop new
imaging/sensing tools (Aim 1), determine the kinetics of NP tumor targeting (Aim 2), and optimize NPmediated selective photothermolysis (Aim 3). The final outcome of this project will demonstrate highly
selective cancer cell killing without damaging immediately adjacent normal cells (Aim 4).
Project: A Laser Microbeam and Medicine Biotechnology Resource
P41 RR01192 (Tromberg)
04/01/08-03/31/13
1.2 cal mo
NIH/NCRR
$5,369,718 (total cost)
AJ Durkin, Co-Director, Wide-field Imaging: I am responsible for oversight of the design,
construction and deployment of 3 new versions of spatial frequency domain imaging, the
modeling efforts associated with each, and the deployment of these devices into appropriate
projects, both clinical and preclinical. In addition, I am responsible for regularly reviewing the
data, directing revision of the instrument as needed, and updating the LAMMP project database
that tracks both new and existing projects and instrument usage. . Finally, I am responsible for
writing the 5 year renewal of the WiFI section of the LAMMP grant in Spring 2012.
PHS 398/2590 (Rev. 05/01)
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The Laser Microbeam and Medical Program (LAMMP) is dedicated to the use of lasers and optics in
biology and medicine. Core programmatic research areas involve development of technologies for
enhancing our understanding of how light interacts with and propagates through cells and tissues.
These technologies are available for shared used by the research community.
Overlap
NONE
Pending
Completed
ARRA Supplement to P41 RR01192 (Tromberg)
08/15/09-09/14/11
1.2 cal mo
NIH/NCRR
$995,000 (total cost)
AJ Durkin, Co-Director, Wide-field Imaging: I am responsible for oversight of the design, construction and
deployment of a new clinical version of spatial frequency domain imaging. In addition, I am responsible
for clinical study design related to burn wound severity assessment, regularly reviewing the data,
revising the instrument as needed, and reporting the results.
This is an American Recovery and Reinvestment Act Supplement to the NIH/NCRR Laser Microbeam and
Medicine Program. The focus of this work, as far as Dr. Durkin is concerned, is to develop, test and deploy a
Wide-field Functional Imaging device to the clinic in two new areas: 1) for the assessment of burn wound severity
and 2) noninvasive assessment of neonatal brain function.
Project: Advanced Optical Technologies for Defense Trauma and Critical Care – Advanced Surgical Camera
Military Photomedicine Program
07/01/10-06/30/11
2.5 cal mo
Air Force Office of Scientific Research
$200,000 direct
AJ Durkin, PI for Advanced Surgical Camera: Role: I am responsible for oversight of the design,
construction and deployment of an Advanced Surgical Camera based on spatial frequency domain
imaging, the modeling efforts associated with this, testing and validation as well as the deployment of
this device into appropriate projects, both clinical and preclinical. In addition, I am responsible for
identifying appropriate collaborations, regularly reviewing the data, directing revision of the instrument
as needed, and annual reporting to the AFOSR.
The goal of my sub-section of this proposal to is to develop and test a Spatial Frequency Domain Imaging system
for management of battle casualties.
Project: Modulated Imaging: A Wide-field Optical Imaging Platform for Clinical Research
SBIR 1R43 RR025985 (Cuccia, Durkin)
05/15/09-05/30/11
1.8 cal mo
NIH – NCRR $256,749 total to UCI
AJ Durkin, PI: I am responsible for providing specifications for the system design related to skin
imaging and am responsible for directing the efforts to characterize the performance of the
resulting system and reporting the results of these efforts. In addition, I am responsible for
directing efforts to collect and analyze data from 4 different areas of clinical application
including 1) normal skin imaging, 2) Port-wine stain imaging, 3) reconstructive flap imaging and
4) pigmented lesion imaging.
This project will develop a robust, non-contact imaging platform which implements the Modulated
Imaging technology. This instrument will target hospital Operating Rooms and ICU’s to provide doctors
with accurate information concerning tissue health.
Project: Impact of hypertonic-hyperoncotic saline solutions on ischemia-reperfusion injury in free flaps
using Modulated Imaging
R03 EB009451-01 (Durkin, Evans)
04/01/09-03/31/11
1.2 cal mo
NIH/NIBIB
$50,000 total direct
AJ Durkin, PI: I am responsible for directing the efforts focused on the use of spatial frequency
domain imaging in a preclinical model of free flap. I direct the study design and protocol
formulation and planning and execution of the work, regularly reviewing the data and reporting
the results.
We propose to test a new imaging device that will have the capability to guide reconstructive surgery
and post-surgical recovery, both reducing post-surgery morbidity and reducing uncertainty in flap
healing. Ultimately, if shown to be effective this technology may lead to reduced duration of hospital
stay and concomitant health care costs in addition to improving surgical outcomes.
PHS 398/2590 (Rev. 05/01)
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