Oxandrolone Use After Burn Injury
Study
Main
Research Sample
Purpose
Design
Outcome
Measures
Results
Study
Level of
Category Evidence
Analysis of RNA
and changes in
protein synthesis
in vastus lateralis
muscle biopsy.
Documented changes in gene
expression with oxandrolone
compared to placebo and increase
muscle protein synthesis. 2 genes
were significantly changed in
placebo group compared to 21
genes in treatment group.
Therapeutic
II
Significant increase in weight gain
Therapeutic
after 3 weeks of treatment in group
treated with oxandrolone compared
to high protein diet group and control
group.
I
Barrow,
200315
To examine
gene
expression
changes with
oxandrolone.
Randomized
prospective.
14 children between
3 and 18 years of
age admitted to burn
center at least 1
week after burn
injury. Average burn
size 42%. 7 subjects
treated with
oxandrolone
0.1mg/kg twice a
day and 7 in placebo
group.
Demling,
199710
To examine
weight gain in
burn patients
treated with
oxandrolone.
Randomized
prospective.
Subjects
treated with
high protein
diet or with
high protein
diet and
oxandrolone.
Patients were adults Weight gain.
admitted to rehab
center and had 3050% TBSA burn and
determined to be in
a recovery (not
catabolic) stage. 7
patients treated with
oxandrolone and
high protein diet; 6
patients treated with
high protein diet; and
10 subjects in
retrospective control
group with a lower
protein diet.
Demling,
199911
To compare
oxandrolone
and growth
hormone
treatment after
burn injury.
Randomized
to oxandrolone
or growth
hormone
treatment
group.
Prospective.
Control group
not part of
randomization.
Control group
consisted of
patients
admitted with
major burns
that did not
meet criteria
for use of
anabolic
agent.
Patients with >50%
TBSA or >25%
TBSA with comorbid
factors (>60 years
old, malnutrition,
adult onset
diabetes). 20 treated
with growth
hormone, 16 with
oxandrolone.
Treatment started 710 days post-burn.
Burn patients that
did not meet these
inclusion criteria
were included in a
control group. The
control group had
smaller burns.
Weight loss,
Nitrogen loss, and
donor site healing
days.
Weight loss and nitrogen loss was
Therapeutic
significantly less in anabolic agent
groups compared to control group.
Donor site healing was completed in
fewer days in the anabolic agent
groups compared to control. No
difference between oxandrolone and
growth hormone groups.
III
Demling,
200012
To examine
the effects of
oxandrolone in
the acute
phase of burn
injury.
Randomized,
prospective,
double-blinded
and placebo
controlled.
Treated with
oxandrolone
or placebo.
11 patients treated
with oxandrolone, 9
with placebo
beginning day 2-3
after burn injury. 4070% TBSA burn
injuries.
Weight loss,
Nitrogen loss,
donor graft site
healing days.
Significantly less weight loss and
nitrogen loss in oxandrolone group.
Significantly fewer days to heal the
donor site in oxandrolone group.
I
Therapeutic
Demling,
200113
To examine
the effect of
oxandrolone
after burn
injury and the
effect of age.
Randomized,
prospective.
Subjects
randomized to
nutrition and
exercise group
or nutrition
exercise and
oxandrolone
group.
Patients with 30Weight gain.
55% TBSA burns.
Subjects divided into
young group (age
18-40) with N=25
and older group (55
years and older) with
N=15.
Significant weight increase in the
oxandrolone group in both age
groups.
Therapeutic
I
Demling,
200314
To examine
long-term
effects of
treatment with
oxandrolone.
Randomized,
Prospective.
Subjects
treated with
oxandrolone
or placebo
during
hospitalization
45 subjects admitted Weight loss, lean
to rehabilitation
body mass
center with major
burn injuries.
Significant increase in weight and
Therapeutic
lean body mass in oxandrolone
group during hospitalization. No
significant difference between groups
in weight gain at 6 months after
stopping oxandrolone, but there was
a significant difference in lean body
mass at 6 months.
I
Hart, 200116 To examine
effects of
treatment with
oxandrolone in
children with
burn injuries.
Prospective,
cohort study.
Subjects
treated with
oxandrolone
and compared
to control
group.
14 children < 18
years of age with
greater than 20%
TBSA burns
admitted to burn
center greater than
one week after burn
injury. Average days
to admission were
28 in control group
and 39 days in
oxandrolone group.
Protein kinetic
studies to
determine protein
balance, rate of
protein synthesis
in muscle biopsy
specimens.
Significantly greater muscle protein
synthesis in subjects after 5 days of
treatment with oxandrolone.
Therapeutic
II
Murphy,
200417
Randomized,
Prospective,
doubleblinded.
Subjects
treated with
oxandrolone
Children <18 years
old admitted to
hospital with >40%
TBSA burns.
Resting energy
expenditure, lean
body mass, bone
mineral content
and bone mineral
density.
Significantly greater lean body mass Therapeutic
at 6, 9 and 12 months after the burn,
and significantly greater bone
mineral content at 12 months, and
significantly greater bone mineral
density at 6, 9, 12 months in group
treated with oxandrolone.
I
Long-term
follow-up of
children
treated with
oxandrolone.
or placebo
from the time
of hospital
discharge to 1
year after
injury.
Outcome
evaluation at
hospital
discharge and
at 6, 9 and 12
months postburn.
Wolf, 200318 To examine
the effects of
oxandrolone
when started
early after
burn injury.
Randomized,
Prospective.
Subjects
treated with
oxandrolone
or placebo.
32 Children less
than 18 years of age
with >30% TBSA
burn admitted to
burn center within 2
weeks of burn injury.
14 treated with
oxandrolone and 18
with placebo.
Protein balance,
Significant improvement in net
rate of protein
protein balance in oxandrolone
synthesis in
treated group.
muscle biopsy
specimens taken
one week after the
start of treatment.
Therapeutic
I