Supplementary Table 3. Quality assessment of intervention studies Study Randomization Appropriate statistical testing Concurrent comparison >70% adherence <20% participants lost to follow-up Reliability/ validity of the exposure assessment Reliability/ validity of the outcome Blinded Measurement Score 0 0 0 1 0 1 1 1 1 1 1 0 1 0 0 0 0 0 0 0 1 1 1 0 0 ? ? 1 ? 0 ? ? ? 1 1 ? ? 0 0 0 0 ? ? ? ? 1 ? 1 1 0 0 1 0 1 ? 0 0 0 0 1 1 0 0 1 0 1 1 0 0 1 1 0 0 1 0 0 1 0 1 1 1 1 1 1 1 1 0 1 0 0 0 1 1 1 1 1 1 1 0 0 1 1 0 0 1 1 1 0 ? 0 1 1 0 1 1 ? ? 1 ? 1 0 1 1 1 1 1 1 1 1 ? 1 1 1 1 0 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 ? 1 1 1 1 1 1 1 1 1 1 1 1 1 0 0 ? ? ? ? 0 0 0 ? 1 0 ? 0 ? ? ? ? ? ? ? 0 1 4 4 5 4 4 4 5 7 7 2 2 6 3 4 2 4 4 4 4 6 4 7 3 0 1 0 1 0 0 1 1 0 1 0 1 0 0 1 1 1 1 1 1 1 0 1 ? 5 5 4 Adults Battaglini et al. 2009(1) Blaauwbroek 2009(2) Carlson 2006(3) Chang 2008(4) Cohen 2004(5) Coleman 2003(6) Coleman 2003(7) Coleman, 2008(8) Courneya 2009(9) Courneya 2009(10) Cunningham 1986(11) Decker 1989(12) DeFor 2007(13) Dimeo 1996(14) Dimeo 2003(15) Elter et al. 2009 Hayes 2003(16) Hayes 2003(17) Hayes 2004(18) Hayes 2004(19) Kim 2006(20) Mello 2003(21) Shelton 2009(22) Wilson 2005(23) Children Chamorro-Vina in press(24) Hartman 2009(25) Keats 2008(26) Ladha 2006(27) Marchese 2004(28) Moyer-Mileur 2009(29) Oldervoll 2003(30) Ruiz in press(31) San Juan 2007(32) San Juan 2007(33) San Juan 2008(34) Sharkey 1993(35) Shore 1999(36) Takken 2009(37) 0 0 1 0 0 0 0 0 0 0 0 1 0 0 0 1 1 1 1 0 0 0 0 1 1 1 0 0 0 1 0 1 0 1 1 ? 0 1 1 1 1 1 ? ? 1 1 1 0 1 1 1 1 0 ? 0 1 1 1 1 1 1 1 0 1 1 1 1 1 1 1 1 1 1 0 1 1 1 ? ? ? 0 1 0 0 0 0 ? 0 5 6 5 3 6 5 5 4 3 3 2 References for Supplementary Table 3 1. Battaglini CL, Hackney AC, Garcia R, Groff D, Evans E, Shea T. The effects of an exercise program in leukemia patients. Integr Cancer Ther 2009 Jun; 8(2): 130-138. 2. Blaauwbroek R, Bouma MJ, Tuinier W, Groenier KH, de Greef MHG, Meyboom-de Jong B, et al. The effect of exercise counselling with feedback from a pedometer on fatigue in adult survivors of childhood cancer: a pilot study. Support Care Cancer 2009; 17: 1041-1048. 3. Carlson LE, Smith D, Russell J, Fibich C, Whittaker T. Individualized exercise program for the treatment of severe fatigue in patients after allogeneic hematopoietic stem-cell transplant: a pilot study. Bone Marrow Transplant 2006 May; 37(10): 945-954. 4. Chang PH, Lai YH, Shun SC, Lin LY, Chen ML, Yang Y, et al. Effects of a walking intervention on fatigue-related experiences of hospitalized acute myelogenous leukemia patients undergoing chemotherapy: a randomized controlled trial. Journal of pain and symptom management 2008 May; 35(5): 524-534. 5. Cohen L, Warneke C, Fouladi RT, Rodriguez MA, Chaoul-Reich A. Psychological adjustment and sleep quality in a randomized trial of the effects of a Tibetan yoga intervention in patients with lymphoma. Cancer 2004 May 15; 100(10): 2253-2260. 6. Coleman EA, Coon S, Hall-Barrow J, Richards K, Gaylor D, Stewart B. Feasibility of exercise during treatment for multiple myeloma. Cancer Nurs 2003 Oct; 26(5): 410-419. 7. Coleman EA, Hall-Barrow J, Coon S, Stewart CB. Facilitating exercise adherence for patients with multiple myeloma. Clin J Oncol Nurs 2003 Sep-Oct; 7(5): 529-534, 540. 8. Coleman EA, Coon SK, Kennedy RL, Lockhart KD, Stewart CB, Anaissie EJ, et al. Effects of exercise in combination with epoetin alfa during high-dose chemotherapy and autologous peripheral blood stem cell transplantation for multiple myeloma. Oncol Nurs Forum 2008 May; 35(3): E53-61. 9. Courneya KS. Effects of Aerobic Exercise on Physical Functioning and Quality of Life in Lymphoma Patients: A Randomized Controlled Trial. Journal of Clinical Oncology 2009 April 27, 2009: 1-21. 10. Courneya KS, Sellar CM, Stevinson C, McNeely ML, Friedenreich CM, Peddle CJ, et al. Moderator effects in a randomized controlled trial of exercise training in lymphoma patients. Cancer Epidemiol Biomarkers Prev 2009 Oct; 18(10): 2600-2607. 11. Cunningham BA, Morris G, Cheney CL, Buergel N, Aker SN, Lenssen P. Effects of resistive exercise on skeletal muscle in marrow transplant recipients receiving total parenteral nutrition. JPEN J Parenter Enteral Nutr 1986 Nov-Dec; 10(6): 558-563. 12. Decker WA, Turner-McGlade J, Fehir KM. Psychosocial aspects and the physiological effects of a cardiopulmonary exercise program in patients undergoing bone marrow transplantation (BMT) for acute leukemia (AL). Transplant Proc 1989 Feb; 21(1 Pt 3): 3068-3069. 13. DeFor TE, Burns LJ, Gold EM, Weisdorf DJ. A randomized trial of the effect of a walking regimen on the functional status of 100 adult allogeneic donor hematopoietic cell transplant patients. Biol Blood Marrow Transplant 2007 Aug; 13(8): 948-955. 14. Dimeo F, Bertz H, Finke J, Fetscher S, Mertelsmann R, Keul J. An aerobic exercise program for patients with haematological malignancies after bone marrow transplantation. Bone Marrow Transplant 1996 Dec; 18(6): 1157-1160. 15. Dimeo F, Schwartz S, Fietz T, Wanjura T, Boning D, Thiel E. Effects of endurance training on the physical performance of patients with hematological malignancies during chemotherapy. Support Care Cancer 2003 Oct; 11(10): 623-628. 16. Hayes S, Davies PS, Parker T, Bashford J. Total energy expenditure and body composition changes following peripheral blood stem cell transplantation and participation in an exercise programme. Bone Marrow Transplant 2003 Mar; 31(5): 331-338. 17. Hayes SC, Rowbottom D, Davies PS, Parker TW, Bashford J. Immunological changes after cancer treatment and participation in an exercise program. Medicine and science in sports and exercise 2003 Jan; 35(1): 2-9. 18. Hayes SC, Davies PS, Parker TW, Bashford J, Green A. Role of a mixed type, moderate intensity exercise programme after peripheral blood stem cell transplantation. Br J Sports Med 2004 Jun; 38(3): 304-309; discussion 309. 19. Hayes S, Davies PS, Parker T, Bashford J, Newman B. Quality of life changes following peripheral blood stem cell transplantation and participation in a mixed-type, moderate-intensity, exercise program. Bone Marrow Transplant 2004 Mar; 33(5): 553-558. 20. Kim SD, Kim HS. A series of bed exercises to improve lymphocyte count in allogeneic bone marrow transplantation patients. European journal of cancer care 2006 Dec; 15(5): 453-457. 21. Mello M, Tanaka C, Dulley FL. Effects of an exercise program on muscle performance in patients undergoing allogeneic bone marrow transplantation. Bone Marrow Transplant 2003 Oct; 32(7): 723-728. 22. Shelton ML, Lee JQ, Morris GS, Massey PR, Kendall DG, Munsell MF, et al. A randomized control trial of a supervised versus a self-directed exercise program for allogeneic stem cell transplant patients. Psychooncology 2009 Apr; 18(4): 353-359. 23. Wilson RW, Jacobsen PB, Fields KK. Pilot study of a home-based aerobic exercise program for sedentary cancer survivors treated with hematopoietic stem cell transplantation. Bone Marrow Transplant 2005 Apr; 35(7): 721-727. 24. Chamorro-Vina C, Ruiz JR, Santana-Sosa E, Vicent MG, Madero L, Perez M, et al. Exercise during hematopoietic stem cell transplant hospitalization in children. Medicine and science in sports and exercise 2010 epub online. 25. Hartman A, te Winkel ML, van Beek RD, de Muinck Keizer-Schrama SM, Kemper HC, Hop WC, et al. A randomized trial investigating an exercise program to prevent reduction of bone mineral density and impairment of motor performance during treatment for childhood acute lymphoblastic leukemia. Pediatr Blood Cancer 2009 Jul; 53(1): 64-71. 26. Keats MR, Culos-Reed SN. A community-based physical activity program for adolescents with cancer (project TREK): program feasibility and preliminary findings. J Pediatr Hematol Oncol 2008 Apr; 30(4): 272-280. 27. Ladha AB, Courneya KS, Bell GJ, Field CJ, Grundy P. Effects of acute exercise on neutrophils in pediatric acute lymphoblastic leukemia survivors: a pilot study. J Pediatr Hematol Oncol 2006 Oct; 28(10): 671-677. 28. Marchese VG, Chiarello LA, Lange BJ. Effects of physical therapy intervention for children with acute lymphoblastic leukemia. Pediatr Blood Cancer 2004 Feb; 42(2): 127-133. 29. Moyer-Mileur LJ, Ransdell L, Bruggers CS. Fitness of children with standard-risk acute lymphoblastic leukemia during maintenance therapy: response to a home-based exercise and nutrition program. J Pediatr Hematol Oncol 2009 Apr; 31(4): 259-266. 30. Oldervoll LM, Kaasa S, Knobel H, Loge JH. Exercise reduces fatigue in chronic fatigued Hodgkins disease survivors--results from a pilot study. Eur J Cancer 2003 Jan; 39(1): 57-63. 31. Ruiz JR, Fleck SJ, Vingren JL, Ramirez M, Madero L, Fragala MS, et al. Preliminary findings of a 4-month intra-hospital exercise training intervention on IGFs and IGFBPs in children with leukemia. Journal of Strength and Conditioning Research 2010; in press. 32. San Juan AF, Fleck SJ, Chamorro-Vina C, Mate-Munoz JL, Moral S, Perez M, et al. Effects of an intrahospital exercise program intervention for children with leukemia. Medicine and science in sports and exercise 2007 Jan; 39(1): 13-21. 33. San Juan AF, Fleck SJ, Chamorro-Vina C, Mate-Munoz JL, Moral S, Garcia-Castro J, et al. Early-phase adaptations to intrahospital training in strength and functional mobility of children with leukemia. J Strength Cond Res 2007 Feb; 21(1): 173-177. 34. San Juan AF, Chamorro-Vina C, Moral S, Fernandez del Valle M, Madero L, Ramirez M, et al. Benefits of intrahospital exercise training after pediatric bone marrow transplantation. Int J Sports Med 2008 May; 29(5): 439-446. 35. Sharkey AM, Carey AB, Heise CT, Barber G. Cardiac rehabilitation after cancer therapy in children and young adults. The American journal of cardiology 1993 Jun 15; 71(16): 1488-1490. 36. Shore S, Shepard RJ. Immune responses to exercise in children treated for cancer. J Sports Med Phys Fitness 1999 Sep; 39(3): 240-243. 37. Takken T, van der Torre P, Zwerink M, Hulzebos EH, Bierings M, Helders PJ, et al. Development, feasibility and efficacy of a communitybased exercise training program in pediatric cancer survivors. Psychooncology 2009 Apr; 18(4): 440-448.