CURRICULUM VITAE CHE-CHUAN LOONG, M.D., Ph.D. PERSONAL HISTORY Born: Taipei, Taiwan, Republic of China March 4, 1955 Address: Office: Division of Transplantation Surgery Department of Surgery Taipei Veterans General Hospital 201, Sec. 2, Shih-Pai Road, Taipei, Taiwan, Republic of China 112 Tel: (886-2) 28757625 Fax: (886-2) 28757537 E-mail: ccloong@vghtpe.gov.tw Education: Medical School: Kaohsiung Medical College Kaohsiung, Taiwan 1975-1982 M.D., June, 1982. Graduate School: Institute of Clinical Medicine School of Medicine National Yang-Ming University Taipei, Taiwan Ph.D., July, 2000. POSTDOCTORAL TRAINING 1984-1988 Resident, Department of Surgery Taipei Veterans General Hospital Taipei, Taiwan 1988-1989 Chief Resident, Department of Surgery Taipei Veterans General Hospital Taipei, Taiwan PROFESSIONAL APPOINTMENTS 1989- ` Attending Surgeon, Division of General Surgery Department of Surgery Taipei Veterans General Hospital Taipei, Taiwan 2005- Chief, Division of Transplantation Surgery 1 Department of Surgery Taipei Veterans General Hospital Taipei, Taiwan ACADEMIC APPOINTMENTS 1999- Lecturer, Department of Surgery School of Medicine National Yang-Ming University 2005- Associate Professor, Department of Surgery School of Medicine National Yang-Ming University MEMBERSHIP IN PROFESSIONAL SOCIETIES The Transplantation Society International Liver Transplantation Society Transplantation Society of Taiwan Surgical Association, Taiwan Surgical Society of Gastroenterology, R.O.C Chinese Association for Endoscopic Surgery 2 Che-Chuan Loong M.D.,Ph.D. Publications: 1. Loong CC, Huang MH, Chien KY. Perforation and rupture of the esophagus - ten years of experience. J Surg Assoc R.O.C 1987; 20:193-201. 2. 龍藉泉:腎臟移植-外科方面的一些問題,腎臟與透析。1991; 3:168-172. 3. Jwo SC, Chiu YH, Chau GY, Loong CC, Lui WY. Risk factors linked to tumor recurrence of human hepatocellular carcinoma after hepatic resection. Hepatology 1992; 16:1367-1371. 4. Chiu YH, Wu LH, Kao HL, Chang HM, Tsay SH, Loong CC, Chau GY, Lui WY. Can determination of the proliferative capacity of the nontumor portion predict the risk of tumor recurrence in the liver remnant after resection of human hepatocellular carcinoma? Hepatology 1993; 18:96-102. 5. Lu SH, Chiu AW, Loong CC, Wu LH, Chen MT, Chang LS. Flow cytometric deoxyribonucleic acid analysis of bilateral renal cell carcinoma. J Urol R.O.C 1993; 4:1235-1239. 6. Lin CY, Chen WP, King KL, Loong CC. Pediatric renal transplantation in Veterans General Hospital - Taipei, Taiwan. Transplant Proc 1994; 26:57-59. 7. Sun LW, Loong CC, Chiu JH, Chau GY, Jwo SC, Lui WY. Definitive surgery for perforated peptic ulcer in the elderly. J Surg Assoc R.O.C 1994; 27:2351-2358. 8. Lee SF, Yang WC, Loong CC, King KL, Lin MF. Individualization of cylcosporine therapy in renal transplantation. Transplant Proc 1994; 26:1917-1919. 9. Chang YT, Loong CC, Wang HC, Jwo SC, Lui WY. Breast cancer and pregnancy. Chin Med J ( Taipei ) 1994; 54:223-229. 10. Lui WY, Chau GY, Loong CC, Tsay SH, Wu JC, King KL, Chiu JH, Lai CR, P'eng FK. Hepatic segmentectomy for curative resection of primary hepatocellular carcinoma. Arch Surg 1995; 130:1090-1097. 11. Su CH, Shyr YM, Loong CC, Yu TJ, Wu JK, Liu M, Lee CH, Lui WY. The use of octreotide in the treatment of pancreatic cutaneous fistula. J Surg Assoc R.O.C 1995; 28:468-476. 12. Loong CC, Chen A, Lui WY, King KL, Lin CY. Expression of Cytokines, Growth Factors, and Adhesion Molecules in Rejecting Human Renal Allograft. Transplant Proc 1996; 28:1445-1446. 13. Tung WY, Chau GY, Loong CC, Wu JC, Tsay SH, King KL, Huang SM, Chiu JH, Wu CW, Lui WY. Surgical resection of primary hepatocellular carcinoma extending to adjacent organ(s). Eur J Surg Oncol 1996; 22:516-520. 14. Shen KH, Loong CC, Chau GY, Chiu JH, Wu CW, Lui WY. Factors related to mortality in patients with mesenteric infarction. J Surg Assoc R.O.C 1996; 29:391-395. 3 15. Chiu ST, Chiu JH, Lui WY, Chau GY, Loong CC, Wu CW. Prognostic factors affecting long-term survival after partial hepatectomy for human hepatocellular carcinoma. Chin Med J ( Taipei ) 1997; 59:177-185. 16. Yu SY, Chiu JH, Loong CC, Wu CW, Lui WY. Diagnostic laparoscopy: indication and benefit. Chin Med J ( Taipei ) 1997; 59:158-163. 17. Sun DP, Loong CC, Chiu JH, Lui WY, Wu CW. Clinical consequence of adenocarcinoma in the jejunum and ileum. J Surg Assoc R.O.C 1997; 30:162-168. 18. Ou LH, Chau GY, Tsay SH, Chiu JH, Wu JC, King KL, Loong CC, Wu CW, Lui WY. Clinicopathological comparison of resectable hepatocellular carcinoma between the young and the elderly patients. Chin Med J ( Taipei ) 1997; 60:40-47. 19. Chau GY, Lui WY, Tsay SH, King KL, Loong CC, Chiu JH, Wu CW, P’eng FK. Prognostic significance of surgical margin in hepatocellular carcinoma resection: an analysis of 165 Child’s A patients. J Surg Onco 1997; 66:122-126. 20. Chiu JH, Lui WY, Chang HM, Loong CC, Wu LH, Kao HL, Wu CW. Class I and Class II major histocompatibility complex antigens expression on human hepatocytes and hepatoma cells: an approach with high sensitivity and specificity. Cytometry 1997; 30:317-323. 21. 龍藉泉:移植醫學未來之趨勢,臨床醫學。1998; 42:55-58. 22. Lui WY, Chiu ST, Chiu JH, Loong CC, Chau GY, King KL, Hsia CY, Wu CW, P'eng FK. Evaluation of a simplified staging system for prognosis of hepatocellular carcinoma. J Formosa Med Assoc 1999; 98:248-253. 23. 龍藉泉:小腸移植,臨床醫學。1999; 44:266-271. 24. 龍藉泉:復發性鼠蹊部疝氣,臨床醫學。1999; 44:412-413. 25. Chenhsu RY, Loong CC, Chou MH, Lin MF, Yang WC. Renal allograft dysfunction associated with rifampin-tacrolimus interaction. Ann Pharmacother 2000; 34:27-31. 26. Huo TY, Yang WC, Wu JC, King KL, Loong CC, Lin CY, Lui WY. Impact of hepatitis B and C virus infection on the outcome of kidney transplantation in Chinese patients. Chin Med J (Taipei) 2000; 63:93-100. 27. Chen JH, Chau GY, Lui WY, Tsay SH, King KL, Loong CC, Hsia JY, Wu CW. Surgical results in patients with Hepatitis B related hepatocellular carcinoma and positive hepatitis B early antigen. World J Surg 2000; 24:383-388. 28. Chau GY, Wu CW, Lui WY, Chang TJ, Kao HL, Wu KH, King KL, Loong CC, Hsia CY, Chi CW. Serum interleukin-10 but not interleukin-6 is related to clinical outcome in patients with resectable hepatocellular carcinoma. Ann Surg 2000; 231:552-558. 29. Tsai TJ, Chau GY, Lui WY, Tsay SH, King KL, Loong CC, Hsia CY, Wu CW. Clinical significance of microscopic tumor venous invasion in patients with resectable hepatocellular carcinoma. Surgery 2000; 127:603-608. 4 30. Hsia CY, Lui WY, Chau GY, King KL, Loong CC, Wu CW. Perioperative safety and prognosis in hepatocellular carcinoma patients with impaired liver function. J Am Coll Surg 2000; 190:574-579. 31. Fan YG, Chiu JH, Chau GY, Loong CC, Lee RC, Tsay SH, Wu CC, Lui WY. Clinical manifestation of hepatic hemangioma undergoing partial liver resection. Formosan J Surg 2000; 33:59-65. 32. Lee CC, Chau GY, Lui WY, Tsay SH, King KL, Loong CC, Hsia CY, Wu CW. Better post-resectional survival in female cirrhotic patients with hepatocellular carcinoma. Hepato-Gastroenterol 2000; 47:446-449. 33. Yang WC, Chen YF, King KL, Wu TH, Chen Hsu RY, Tang JJ, Loong CC, Chou MH, Lin MF, Lui WY. Optimization of cyclosporine therapy with abbreviated area under the curve method in renal transplant. Transplant Proc 2000; 32:1685-1687. 34. Loong CC, Lin CY, Lui WY. Expression of interleukin-17 as a predictive parameter in acute renal allograft rejection. Transplant Proc 2000; 32:1773 35. Huo TI, Yang WC, Wu JC, King KL, Lin CY, Loong CC, Lui WY, Chang FY, Lee SD. Long-term outcome of kidney transplantation in patients with hepatitis C virus infection. Hepato-Gastroenterol 2001; 48:169-173. 36. Huo TI, Yang WC, Wu JC, King KL, Loong CC, Lin CY, Chang FY, Lee SD. Kidney transplantation in patients with chronic hepatitis B virus infection-is the prognosis worse? Dig Dis Sci 2001; 46:469-475. 37. Chen TH, Tseng LM, Chau GY, Lui WY, Tsay SH, King KL, Loong CC, Hsia CY, Wu CW. Clinicopathologic and prognostic differences between patients with Hepatitis B- and C-related respectable hepatocellular carcinoma. J Formos Med Assoc 2001; 100:443-448. 38. Hsieh HG, Loong CC, Lui WY, Chen A, Lin CY. IL-17 expression as a possible predictive parameter for subclinical renal allograft rejection. Transplant Int 2001; 14:287-298. 39. Loong CC, Chiu JH, Tiao RC, Chiu YY, Wu CW, Lui WY. Pretreatment with magnolol attenuates ischemia-reperfusion injury in rat small intestine. Transplant Proc 2001; 33:3737-3738. 40. Loong CC, Hsieh HG, Lui WY, Chen A, Lin CY. Evidence for the early involvement of interleukin 17 in human and experimental renal allograft rejection. J Pathol 2002; 197:322-332. 41. Hsieh HG, Loong CC, Lin CY. Interleukin-17 induces src/MAPK cascades activation in human renal epithelial cells. Cytokine 2002; 19:159-174. 42. Loong CC, Chiu JH, Tiao RC, Chiu YY, Wu CW, Lui WY. Protective effect of magnolol on the small intestinal ischemia-reperfusion injury. Transplant Proc 2002; 34:2679-2680. 43. Hsia CY, Chau GY, King KL, Loong CC, Lui WY, Wu CW. Factors for prolonged length of stay after elective hepatectomy for hepatocellular carcinoma. The surgeon’s role in the managed care era. Hepato-gastroenterology 2003; 50:798-804 5 44. Kwok CM, Lui WY, King KL, Loong CC, Chau GY, Kwang WK, Hsia CY, Wu CW. Intrahepatic splenosis: report of a case. Formos J Surg 2003; 36:301-305. 45. Huo TI, Wu JC, Lui WY, Lee RC, Loong CC, Huang YH, Tsay SH, Chang FY. Reliability of contemporary radiology to measure tumour size of hepatocellular carcinoma in patients undergoing resection: limitations and clinical implications. Scand J Gastroenterol 2004; 39:46-52. 46. Huo TI, Lui WY, Wu JC, Huang YH, King KL, Loong CC, Lee PC, Chang FY, Lee SD. Deterioration of hepatic functional reserve in patients with hepatocellular carcinoma after resection: incidence, risk factors, and association with intrahepatic tumor recurrence. World J Surg 2004; 28:258-262. 47. Chen WT, Chau GY, Lui WY, Tsay SH, King KL, Loong CC, Wu CW. Recurrent hepatocellular carcinoma after hepatic resection: prognostic factors and long-term outcome. Euro J Surg Onco 2004; 30:414-420. 48. Loong CC, Wu CW, Lui WY. Antioxidant supplementation may improve renal transplant function. Transplant Proc 2004; 36:2438-2439. 49. Hsu CW, Lui WY, Chau GY, King KL, Loong CC, Hsia CY, Lee RC, Li AFY, Wu CW. Clinical characteristics of patients undergoing surgical resection of benign liver tumors in Taiwan, an endemic area for hepatocellular carcinoma. J Formos Med Assoc 2004; 103:824-829. 50. Lee CC, Chau GY, Lui WY, Tsay SH, King KL, Loong CC, Hsia CY, Wu CW. Risk factors associated with bile leakage.after hepatic resection for hepatocellular carcinoma. Hepatogastroenterology 2005; 52:1168-71. 51. Lai HW, Loong CC, Wu CW, Lui WY. Watchful waiting versus interval appendectomy for patients who recovered from acute appendicitis with tumor formation: A cost-effectiveness analysis. J Chin Med Assoc 2005; 68:431-434. 52. Lai HW, Loong CC, Chiu JH, Chau GY, Wu CW, Lui WY. Interval appendectomy after conservative treatment of an appendiceal mass. World J Surg 2006; 30:351-357. 53. Liu C, Tsai HL, Loong CC, Hsia CY, Chin T, Wei C. ENDO-GIA Staplers for Side-to-Side Anastomosis of Veins. Eur J Vasc Endovasc Surg. 2006; 32: 584-8. 54. Lai HW, Loong CC*, Tai LC, Wu CW, Lui WY. Incidence and odds ratio of appendicitis as first manifestation of colon cancer: A retrospective analysis of 1873 patients. J Gastro Hepatolo 2006; 21: 1693-6. 55. Lei HJ, Chau GY, Lui WY, Tsay SH, King KL, Loong CC, Wu CW. Prognostic value and clinical relevance of the 6th edition 2002 American joint committee on cancer staging system in patients with respectable hepatocellular carcinoma. J Am Coll Surg 2006; 203: 426-35. 6 56. Fan WC, King KL, Loong CC, Wu CW. Hepatocellular carcinoma after renal transplantation: the long-term impact of cirrhosis on chronic hepatitis B virus infection. Transplant Proc. 2006;38:2080-3. 57. Liu C, Tsai HL, Chin T, Loong CC, Hsia CY, Wei C. Clamping the supra-celiac aorta can effectively increase the success rate of orthotopic rat liver transplantation by increasing the tolerable time of the anhepatic phase. J Surg Res. 2006;136:116-9. Conference paper: 1. 1995, Aug.27-30:"Expression of cytokines, growth factors, and adhesion molecules in rejecting human renal allograft" in the 4th Congress of the Asian Society of Transplantation, Seoul, Korea. 2. 1996, Mar.14-16:"Management of recurrent inguinal hernia-the usage of mesh repair" in the 55th General Scientific Meeting of Surgical Association, R.O.C, Taipei, R.O.C. 3. 1998, Apr.7-8:"Hepatoma associated with cirrhosis on the influence of postoperative survival" in the 56th General Scientific Meeting of Surgical Association, R.O.C, Taipei, R.O.C. 4. 1998, Jul.4:"Retained gall bladder that mimic biliary leakage-a case report" in the 3rd Annual Meeting and Scientific Meeting of the Chinese Association for Endoscopic Surgery. Taipei, R.O.C. 5. 1999, Mar.11-13:"Treating Incisional Hernia by the concept of GPRVS" in the 58th General Scientific Meeting of Surgical Association, R.O.C. Taipei, R.O.C. 6. 1999, Sep.20-24:"The expression of interleukin-17 as a predictive parameter in acute renal allograft rejection" in the 6th Congress of the Asian Society of Transplantation, Singapore, Singapore. 7. 2001, Jul. 22-27:”The protective effect of Magnolol on the small intestinal Ischemia-reperfusion injury” in the 6th Congress of the International Society for Organ Sharing, Nagoya, Japan. 8. 2001,Aug.20-23,”Pretreatment with Magnolol attenuates the ischemia reperfusion injury in the rat small intestine” in the 2001-A transplant odyssey, the future is here. Istanbul, Turkey. 9. 2002, Mar.23-24,”Inflammatory pseudotumor of the liver: experience of Taipei Veterans General Hospital” in the 61st General Scientific Meeting of Surgical Association, Taiwan. Kaohsiung, R.O.C 10. 2003, Sep. 23-27,”Antioxidant supplementation may improve renal transplant function “ in the 8th congress of the Asian Society of Transplantation, Kuala Lumpur, Malaysia. 11. 2006, Mar. 25-26,”Open repair for the recurrent incisional hernia“ in the 65th General Scientific Meeting of Surgical Association, Taiwan. Tao Yuan, R.O.C 7 Chapters 1. 龍藉泉,腎臟移植之外科觀點,譚柱光、黃東波編著,人工腎臟,第二 版,台北:力大圖書有限公司,1994: 328-338. 2. 龍藉泉,腹腔鏡膽囊切除術之相關解剖學,雷永耀、沈金翰、吳秋文、彭芳谷等主編, 腹腔鏡外科學,台北:九州圖書文物有限公司,1998:115-119. 3. 龍藉泉,胃癌之免疫療法,吳秋文、雷永耀、彭芳谷等主編,胃癌之診斷 北:九州圖書文物有限公司,2000:453-459. 4. 龍藉泉,局部廣泛浸潤性乳癌的治療方式,王惠暢、曾令民、吳秋文、雷永耀、彭芳谷 等主編,乳房疾病新論,台北:九州圖書文物有限公司,2000:225-236. 5. 龍藉泉,第十七介白質在腎臟移植急性排斥的角色,國立陽明大學臨床醫學研究所博士 論文,2000. 6. 龍藉泉,肝臟手術前後之照護診療及合併症之處理,雷永耀、周嘉揚、吳秋文、彭芳谷 等主編,肝臟腫瘤學,台北:合記圖書出版社,2004:265-271. 及治療,台 8