Is oesophagogastroduodenoscopy prior to Roux-en-Y gastric bypass surgery mandatory? Abstract Background and study aims: Roux-Y Gastric Bypass is one of the most frequently used techniques in bariatric surgery for morbidly obese patients. Postoperative anatomy is altered by exclusion of the stomach which makes this organ inaccessible for future Esophagogastroduodenoscopy (EGD). There is no definite consensus about preoperative assessment of the stomach. Some institutions choose to investigate the future remnant stomach by EGD, others do not. Aim of the present study is to quantify the yield of preoperative EGD in our institution. Methods: Patients, who were planned for laparoscopic Roux-Y Gastric Bypass (LRYGB) from December 2007 until August 2012, were screened by EGD in advance. These files were retrospectively reviewed for results of the EGD. In addition the files were searched for comorbidities, medication and other patient characteristic. All these data were analyzed. Results: 664 patients (136 male, 526 female, median age 44.2 years, average BMI 45.6) underwent preoperative EGD. In 341 cases no abnormalities were found (A), 115 patients had findings that did not have consequences (B1), 112 (of 417) patients needed HP eradication therapy (B2), 87 patients needed preoperative treatment by proton pump inhibitors (B3), and 6 patients needed follow up EGD before the surgery (C). For one patient the operation was cancelled because preoperative EGD showed Barrett’s esophagus with carcinoma (D). When all abnormalities are taken into account, baselines show a significant difference for age, gender, hypertension and alcohol. Regarding the treatment consequences, the number needed to treat to find one serious abnormality (postponing/ follow up EGD or cancel operation) is 94,5. Conclusion: Based on our results and the results in the literature we state that standard preoperative assessment by EGD is questionable. The number needed to treat for abnormalities with treatment consequences is high. Undergoing EGD for patients without sedation is not to be taken lightly and also the economic burden of performing EGD in all patients is noteworthy. Authors: U.K. Coblijn M.D1., A. Schigt M.D.1, S.M. Lagarde M.D. PhD.1, P. Scholten M.D.1 , S.D. Kuiken M.D. PhD.2, B.A. van Wagensveld M.D. PhD.1 1= 2 Department of Surgery Sint Lucas Andreas Hospital = Department of Gastroenterology Sint Lucas Andreas Hospital U.K. Coblijn, Submission Digestive Disease Week, Page 1