Multi-Compartment
Pharmacokinetics
Chapters 19 and 20
http://www.boomer.org/c/p4/
One versus Two Compartment
• Rapid Equilibrium versus Slower Equilibrium
http://www.boomer.org/c/p4/c19/c1901.html
Multi-Compartment Pharmacokinetic
Model
•
•
•
•
•
•
•
•
Deviation from One Compartment Model
Models and Parameters
Equations
Parameter Estimation
Effect of Changing Parameters
Apparent Volumes of Distribution
Dosage Calculations
Oral Administration
Multi-Compartment Pharmacokinetic
Model
This Equation is
A. The integrated equation
for concentration after
an IV bolus
B. The differential
equation for
concentration after an
IV bolus
C. The integrated equation
for concentration after
an oral dose
A Two Compartment Model becomes
One when
A. k12 and k21 are fast
B. k21 is faster than
k12
C. CLD is fast
D. All of the above
Varea is Calculated using
A. The dose and the
intercept values (A
and B)
B. The dose, AUC and
beta
C. V1 and the
microconstants
Achieving and
maintaining a
specified Cp is
easier with a 2C
drug
A. True
B. False
Non Compartmental Analysis
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Linear (First-order) Kinetics
No Model ‘Requirement’
New Parameters – AUMC, MRT, MAT
Faster Calculation with Spreadsheet or SAS
Non Compartmental Analysis
The mean residence time can be
calculated as
A.
B.
C.
D.
AUMC/AUC
AUC/AUMC
AUMC2
Dose/AUC
An estimate of ka can be calculated
from
A.
B.
C.
D.
AUC
AUMC
MRT
MAT
Do you usually have
your laptop AND
phone connected to
WiFi in this room?
A. True
B. False
Have you had problems connecting to
the WiFi in this room?
A. Never
B. Occasionally
C. Often
Have you had
problems
connecting to the
WiFi in this room
during in-class Quiz
or Exams
A. True
B. False