MODULE 5
Pharmaceutics
1. RA 8203 was signed into law on:
A. September 4, 1996
D. September 13, 1986
B. September 13, 1988 E. September 4, 1992
C. October 4, 1996
2. A complete pharmacy internship program based
on RA 5921 article III section 18c shall consist of at
least:
A. 480 hours
B. 960 hours
C. 160 hours
D. 980 hours
E. 940 hours
3. This means a method of secret writing that
substitutes other letters or characters for the
letter intended, or transpose the letter after
arranging them in blocks or squares.
A. Code
B. Cipher
C. Secret Keys
D. Substitution
E. NOTA
CODE – system of words or other systems arbitrarily used to
present words
SECRET KEYS – characteristic styles or symbols kept from the
knowledge of others or disclosed confidentially to only one
or a few
4. RA 3720 is also known as:
A.
B.
C.
D.
E.
Pharmacy Law
Consumer Act of the Philippines
Food, Drugs, Cosmetics and Devices Act
Senior Citizens Act
Special Law on Counterfeit Drugs
5. Amount of morphine subject to life
imprisonment to death penalty and a fine of
500,000 pesos to 10M pesos:
A. 500g
B. 50g
C. 10g
D. 1g
E. 20g
MARIJUANA – 500 g
SHABU – 50 g
6. Ratio of the weight of a substance to the weight
of an equal volume of another substance taken as a
standard.
A. Density
B. Specific gravity
C. Optical Activity
D. Refractive index
7. Compute for the specific gravity of potassium
dichromate (K2Cr2O7) if its weight t in air =5.76g and
its weight in oil 3.08g. The sp.gr of the oil is 0.86.
A. 1.86
B. 1.85
C. 1.87
D. 1.88
Sp. Gr = [ wt. in air/ (wt. in air – wt. in oil)] x sp. Gr of oil
8. Floatation method for the determination of
specific gravity is based on whose scientist’s
principle?
A. Aristotle
B. Newton
C. Einstein
D. Archimedes
9. A type of hydrometer which is used to determine
the alcohol strength of any liquid containing only
alcohol and water.
A. Falle’s hydrometer
B. Baume hydrometer
C. Thalles’ hydrometer
D. Nicholson’s hydrometer
Baume hydrometer – used for liquid heavier or lighter than
water
Nicholson’s hydrometer – type of hydrometer with constant
depth of immersion but variable weight. Other examples of
such will be Fahrenheit hydrometer, Lovi’s bead
10. A method of expressing concentration where
in concentration is directly proportional to the
moles of solute and inversely proportional to
the volume of solution
A. %w/v
B. %w/w
C. M
D. m
M – symbol for MOLARITY
m – symbol for MOLALITY
11. The pH value is calculated mathematically as
the:
A. Log of the hydroxyl ion (OH-) concentration.
B. Negative log of the OH- concentration.
C. Log of the hydrogen ion (H+) concentration.
D. Negative log of the H+ concentration.
E. Ratio of H+ /OH- concentration.
12. Which property is classified as colligative?
A. Solubility of a solute
B. Osmotic pressure
C. Hydrogen ion (H+) concentration
D. Dissociation of a solute
E. Miscibility of the liquids
13. Which equation is used to predict the stability
of a drug product at room temperature from
experiments at accelerated temperatures?
A. Stokes equation
B. Young equation
C. Arrhenius equation
D. Michaelis-Menten equation
E. Hixson-Crowel l equation
14. The pH of a buffer system can be calculated
with the:
A. Noyes-Whitney equation
B. Henderson-Hasselbalch equation
C. Michaelis-Menten equation
D. Young equation
E. Stokes equation
15. Based on the relation between the degree of
ionization and the solubility of a weak acid, the
drug aspirin (pKa 3.49) will be most soluble at
A. pH 1.0
B. pH 2.0
C. pH 3.0
D. pH 4.0
E. pH 6.0
16. Normally, how many % of water is contained
in a hard gelatin capsule?
A. 8-10
B. 12-16
C. 20-25
D. 2-5
E. 5-10
17. The largest size of hard, empty gelatin capsule
that can be swallowed is:
A. 00
B. 000
C. 1
D. 5
E. 0
The smaller the number the bigger the capsule
18. This chemical agent is used to render the capsule
opaque
A. Titanium dioxide
B. Sorbitol
C. Magnesium oxide
D. Silica
E. Lactose
19. This is a method of preparing tablets in which
the powder mixture is compacted in large pieces
and subsequently broken down or sized into
granules
A. Wet granulation
B. Dry granulation
C. Direct compression
In dry granulation, the powder mixture is slugged or
compressed into large flat tablets or pellets of about 1 inch in
diameter. The slugs are broken up by hand or by the mill and
pass through a screen.
20. The following statement/s is/are true for wet granulation
method:
I.
Liquid binder is added to the powder mixture to
facilitate the adhesion of the powder particles
II. Over-wetting of the powder can result in granules
that are too soft for proper tableting and under
wetting can result in tablets that are too hard and
tend to crumble
III. Granules may be dried in thermostatically controlled
ovens which constantly record the time,
temperature and humidity
21. Amount of shabu subject to life
imprisonment to death penalty and a fine of
500,000 pesos to 10M pesos:
A. 10g
B. 20g
C. 50g
D. 100g
E. 5000g
22. An ordinary prescription shall be preserved for a
period of_______.
A. 5 years
B. 1 year
C. 3 years
D. 2 years
5 years – POISON
1 year – DANGEROUS DRUGS
23. When the generic name and brand name are
NOT legible, this is a/an___________ prescription.
A. Violative
B. Erroneous
C. Impossible
D. NOTA
Impossible prescription:
•Only the generic name is written but is NOT legible
•Generic name does NOT correspond with the brand name
•Both generic and brand name are NOT legible
•Drug product prescribed is NOT registered with the BFAD
24. Supplies or medicines to be given to senior
citizen should not exceed
A. One day supply
B. One week supply
C. One month supply
D. One year supply
25. Most biological are stored at this
temperature:
A. 2 – 8°F
B. 12 – 8°F
C. 2 – 8°C
D. 12 – 8°C
26. LAL stands for:
A.
B.
C.
D.
Limulus Antibiotic Lysate
Lyophilized Antibiotic Lysate
Limulus Amoebocyte Lysate
Lyophilized Amoebocyte Lysate
27. The normal moisture content of hard gelatine
capsules:
A. 2 -5%
B. 12 – 16%
C. 20 – 24%
D. 25 – 30%
28. When the generic name is not written in a
prescription, this is a case of:
A. Violative prescription C. Impossible prescription
B. Erroneous prescription D. NOTA
Violative prescription:
•Generic name is NOT written
•Generic name is NOT legible and brand name is legible
•Brand name is INDICATED and instructions added (e.g.
“NO SUBSTITUTION”)
29. “Rule of Thumb” is the principle applied for
testing:
A. Ampules
B. Implantations
C. Vials
D. Compressed Tablets
30. It refers to the release or movement of the
components of the plastic container into the
contents:
A. Sorption
B. Absorption
C. Adsorption
D. Leaching
Sorption and Absorption – refers to the binding of drug
molecules to the polymer material of the plastic container
31. It states that vapor pressure of component is
equal to its mole fraction times vapor pressure in
the pure state at that same temperature.
A. Raoult’s law
B. Henry’s law
C. Charles’ law
D. Fick’s law
32. Which of the following is not a colligative
property?
A.
B.
C.
D.
Boiling point elevation
Freezing point depression
Vapor pressure elevation
Osmotic pressure
- vapor pressure LOWERING
33. Dissociation constant for substances that
dissociates into 5 ions
A. 4.2
B. 1.8
C. 3.4
D. 2.6
B – 2 ions
C – 4 ions
D – 3 ions
34. Compute for the E value of Papaverine sulfate
HCl (MW 376) which is a 2 ion electrolyte
dissociating 80% in a given concentration.
A. 0.1554
B. 0.1555
C. 0.1556
D. 0.1557
E= (MW NaCl/i NaCl) x (i substance/ MW substance)
E= (58.5/1.8) x (1.8/376)
E= 0.15558 /0.1556
35. A simplication of the White-Vincent method
where the weight of the drug is fixed in 0.3g for
one fluidounce of a 1% solution.
A.
B.
C.
D.
Modified White-Vincent method
Scowle’s method
Sprowl’s method
Cryoscopic method
36. Dosage form made by compression or
molding
A. Tablets
B. Capsule
C. Syrup
D. Suspension
37. A characteristic of material for compression
which describes the way the material flow thru the
hopper
A. Fluidity
B. Compressibility
C. Dryness
D. Particle size
38. Spray drug lactose when used in direct
compression can hold how many % of active
ingredient?
A. 18%
B. 15%
C. 20%
D. 30%
It can hold 20-25% of the active ingredient
39. Which of the following is not a glidant?
A. CAB-O-SIL
B. DL-Leucine
C. Syloid
D. Talc
- It is solely used as an anti-adherent.
(A), (C), & (D) are used as both glidant and anti-adherent.
Glidants - improve flow property.
Anti-adherent - prevents sticking & picking.
40. Clays are limitedly used for what type of tablets
due to its tendency to cause unwanted
appearance?
A. White tablets
B. Colored tablets
C. Both
D. NOTA
41. Which solution is used as an astringent?
A. Strong iodine solution USP
B. Aluminum acetate topical solution USP
C. Acetic acid NF
D. Aromatic ammonia spirit USP
E. Benzalkonium chloride solution NF
Aluminum acetate - used as antiperspirants and wet dressings for contact
dermatitis
Strong iodine and Benzalkonium chloride – topical antibacterial solutions
Acetic acid - acidifier
Aromatic ammonia spirit – respiratory stimulant
42. The particle size of the dispersed solid in a
suspension is usually greater than
A. 0.5 μm
B. 0.4 μm
C. 0.3 μm
D. 0.2 μm
E. 0.1 μm
A suspension is a two-phase system that consists of
a finely powdered solid dispersed in a liquid vehicle
43. In the extemporaneous preparation of a
suspension, levigation is used to:
A. reduce the zeta potential
B. avoid bacterial growth
C. reduce particle size
D. enhance viscosity
E. reduce viscosity
Levigation is the process of blending and grinding a substance
to separate the particles, reduce their size, and form a paste.
44. Which compound is a natural emulsifying
agent?
A. acacia
B. lactose
C. polysorbate 20
D. polysorbate 80
E. sorbitan
monopalmitate
45. Rectal suppositories intended for adult use
usually weigh approximately
A. 1 g
B. 2 g
C. 3 g
D. 4 g
E. 5 g
46. In the fusion method of making cocoa butter
suppositories, which substance is most likely to be
used to lubricate the mold?
A. Mineral oil
B. Propylene glycol
C. Cetyl alcohol
D. Stearic acid
E. Magnesium silicate
47. A very fine powdered chemical is defined as
one that
A. completely passes through a #80 sieve.
B. completely passes through a #120 sieve.
C. completely passes through a #20 sieve.
D. passes through a #60 sieve and not more
than 40% through a #100 sieve.
E. passes through a #40 sieve and not more than
60% through a #60 sieve.
48. Which technique is typically used to mill
camphor?
A. trituration
B. levigation
C. pulverization by
intervention
D. geometric dilution
E. attrition
Pulverization by intervention is the milling technique that is
used for drug substances that are gummy and tend to reagglomerate or resist grinding (e.g. camphor , iodine)
49. The dispensing pharmacist usually blends
potent powders with a large amount of diluent by
A. spatulation
B. sifting
C. trituration
D. geometric dilution
E. levigation
50. Which type of paper best protects a divided
hygroscopic powder?
A. waxed paper
B. glassine
C. white bond
D. blue bond
E. vegetable parchment
Hygroscopic and volatile drugs are best protected by waxed
paper , which is waterproof.
51. This process is a form of pelletization, which
refers to the formation of spherical particles from
wet granulation
A. Spheronization
B. Slugging
C. Spray chilling
D. Moist heating
E. Dry heating
•Slugging - a process in which the powder mixture is
compressed into large flat tablet or pellet.
52. Which excipient/s is/are used in the
preparation of sugar-free chewable tablets?
I. Lactose
II. Dextrose
A.
B.
C.
D.
E.
I only
III only
I and II
II and III
I, II, III
III. Xylitol
53. This problem corresponds to the filling-in of the
score line or indented logo on the tablet by the film.
A. Peeling
B. Picking
C. Orange peel effect
D. Mottling
E. Bridging
• Peeling - appearance of large amounts of film fragments flaking from the
tablet.
 Picking – appearance of small amounts of film fragments flaking from the
tablet.
 Orange Peel Effect- pertains to the roughness of the tablet surface due to
failure of spray droplets to coalesce.
 Mottling- uneven distribution of color on the tablet surface
 Bridging- Filling in of the score line or indented logo on the tablet by the
film.
54. This type of dosage form allows a reduction in
dosing frequency to that presented by a
conventional dosage form
A. Extended release
B. Delayed release
C. Repeat Action
D. Modified Release
E. Targeted Release
Delayed release- designed to release the drug from the dosage form at a time
other than promptly after administration.
Repeat Action- Usually contains 2 doses of medication one for immediate and
the second for delayed release.
Targeted release - describes drug release directed towards isolating or
concentrating a drug in a body region, tissue or site for absorption or for drug
action.
55. Yellow ointment is an example of
A. Hydrocarbon base
B. Oleaginous base
C. Absorption base
D. Water removable base
E. A & B
Hydrocarbon base is Oleaginous base
56. The following ointment base/s is/are classified
as hydrocarbon base/s
I. Petrolatum
II. White ointment
III. Polyethylene Glycol Ointment
A.
B.
C.
D.
E.
I only
I & II
I & III
III only
I, II, III
57. Polyethylene glycol Ointment, NF is:
A. Hydrocarbon base
B. Water Soluble base
C. Absorption base
D. Water Removable base
E. Oleaginous base
58. These ointment base resembles cream in appearance
A. Hydrocarbon base
B. Water Soluble base
C. Absorption base
D. Water Removable base
E. Oleaginous base
Water removable bases are oil-in-water emulsion
resembling creams in appearance. They are easily
washed from skin and often called “water washable”
base.
59. These are semi-solid adhesive masses spread
upon a backing material paper, fabric, moleskin or
plastic
A. Cream
B. Plaster
C. Paste
D. Ointment
E. Lotion
60. The factor/s which play/s a part in percutaneous
absorption is/are:
I. Molecular Weight
II. Partitioning coefficient
III. Solubility
A.
B.
C.
D.
E.
I only
II only
I & II
II & III
I, II, III
61. In sugar coating of tablets, the greatest
increase in the size of the tablet occurs at what
stage of the process?
A. Sealing
B. Smoothing
C. Color coating
D. Sub coating
E. Polishing
62. Uneven distribution of color on the surface of
tablets is:
A. Peeling
B. Mottling
C. Capping
D. Lamination
E. Picking
63. Strength of a product is expressed in terms of:
A. Potency
B. Activity
C. Toxicity
D. Therapeutic dose
E. Lethal dose
64. An example of a tetragonal crystal system is:
A. Urea
B. Iodoform
C. Iodine
D. Sodium chloride
Iodoform – hexagonal
Iodine – rhombic
Sodium chloride - cubic
65. These are properties which are dependent on the
arrangement and to a lesser extent on the number and
kind of atoms within a molecule:
A. Intensive
B. Colligative
C. Constitutive
D. Extensive
Extensive – DEPENDENT on the quantity of matter in a system
Intensive – INDEPENDENT of the quantity of substance in the
system (e.g. temperature, density, pressure, surface tension,
viscosity)
Colligative - e.g. Osmotic pressure elevation, vapor pressure
lowering, Freezing point depression, and boiling point elevation
66. These are solvents which are capable of acting
both as proton acceptor and proton donor:
A. Protophilic
B. Protogenic
C. Amphiprotic
D. Aprotic
•Protophilic – solvents which are capable of accepting
protons from the solute
•Protogenic – solvent characterized to be proton-donating
compound
•Aprotic – solvents that neither accepts nor donate proton
67. If a substance dissolves in a hundred to a thousand
parts of solvent such substance is characterized to be:
A. Soluble
B. Sparingly soluble
C. Slightly soluble
D. Very slightly soluble
SOLUBILITY
Soluble
10 – 30 parts
Sparingly soluble
30 - 100 parts
Slightly soluble
100 – 1000 parts
Very slightly soluble
1000 – 10000 parts
68. This is also known as the “shear thinning
systems”
A. Pseudoplastic
B. Dilatant
C. Thixotrophic
D. Rheopectic
Dilatant – “shear thickening system”
Thixotrophic – gels and magmas when standing
form semisolids and on shaking become fluid
69. A phenomenon where in a gel takes up liquid
without an observable increase in volume:
A. Sweating
B. Syneresis
C. Swelling
D. Imbibition
Syneresis – phenomenon in which the liquid portion
of a gel is pressed out
Swelling – process which involves the taking up of
liquid by a gel with an observable increase in its
volume
70. This type of solution has a solute concentration
equivalent to its limit of solubility
A. Unsaturated
B. Saturated
C. Supersaturated
D. NOTA
71. Breaking down of materials by rubbing action
between 2 surfaces.
A. Attrition
B. Rolling
C. Impact
D. Scratching
Rolling - uses heavy rolling to crush materials.
Impact - employs hammer/bars at high speed to break
material.
72. All are type of plastic containers, EXCEPT;
A. PVC
B. PET
C. PP
D. PD
PVC - polyvinyl chloride
PET – polyethylene
PP - polypropylene
73. At what percent is is benzalkonium chloride
used?
A. 0.2%
B. 0.1%
C. 0.001%
D. 0.002%
74. A cool place would be
A. <8C
B. 2-8C
C. 8-15C
D. -20 - -15C
75. Composition of the council of pharmaceutical
education, EXCEPT;
A.
B.
C.
D.
Secretary of Education
Dean of UP College of Pharmacy
BFAD
DOST Secretary
76. Qualification for Board examination, except;
A.
B.
C.
D.
E.
Citizen of the Philippines
Moral character
Completed internship
BS Pharmacy graduate
NOTA
77. Revocation of LTO may be due to the following
except;
A.
B.
C.
D.
E.
Selling of drug with “not for sale” mark
Failure to properly record dangerous drugs
Absence of pharmacist
AOTA
NOTA
78. RA 7432
A. Senior Citizen’s Act
B. Pharmacy Law
C. Generic’s Act
D. Dangerous Drugs Act
79. RA 6425
A. Senior Citizen’s Act
B. Pharmacy Law
C. Generic’s Act
D. Dangerous Drugs Act
80. RA 6675
A. Senior Citizen’s Act
B. Pharmacy Law
C. Generic’s Act
D. Dangerous Drugs Act
81. A certain drug is considered counterfeit if it
contains less than how many percent of the active
ingredient it purports to posses?
A. 80
B. 75
C. 60
D. 85
E. 90
Counterfeit drug/medicine refers to a drug which contains no
amount of, or different active ingredients or less than eighty
percent of the active ingredient it purports to possess (RA
8203, Section3)
82. For how many years shall the Chairman and members
of the Board of Pharmacy hold office after appointment?
A. 3
B. 4
C. 5
D. 6
E. 2
83. Any person who shall be employed as detailman by
any pharmaceutical establishment shall be required to
register with the:
A.
B.
C.
D.
E.
PRC
BFAD
Board of Pharmacy
DOH
Council of Pharmaceutical Education
84. Every prescription for external use filled in the
drugstore shall bear what label?
A. Red label
B. White label
C. Red label showing in blank ink the components
and the word “External Use Only”
D. White label showing red ink the Word “External
Use Only”
E. NOTA
85. The pharmacist examination shall consist of the
theoretical examination on the subjects in:
A. Chemistry
B. Biological Science
C. Pharmacy
D. A and C Only
E. AOTA
86. The book kept for the purpose of recording the
sale of poisons shall be open at all timed for
inspection and shall be preserved for a period of at
least __________ years after the last entry.
A. 1
B. 2
C. 3
D. 5
E. 7
87. The following substances are included in the list
of violent poisons stated in RA 5921:
A. Atropine
B. Nitrobenzene
C. Strychnine
D. B and C only
E. AOTA
Also include in the list are arsenical preparations, phosphorus,
corrosive sublimate, hydrocyanic acid or prussic acid and such
other poisonous substances which may be classified as violent
by BFAD (RA 5921, Article IV, Section 34)
88. This means a system of words or other systems
arbitrary used to present words.
A. Code
B. Cipher
C. Secret Keys
D. Substitution
E. NOTA
89. The term Secretary, in RA 3720, means:
A.
B.
C.
D.
Secretary of DOH
Secretary of Dept of Commerce and Industry
Secretary of Education
Secretary of Department of Agricultural
Resources
E. AOTA
90. Under RA 3720, if a food bears or contains any
poisonous or deleterious substances which may
render it injurious to health, it is deemed to be:
A. Poison
B. Adulterated
C. Misbranded
D. Counterfeit
E. Hazardous
91. If the seized drug was found to be counterfeit, the
business establishment must be directed for preventive
closure for a period of:
A. 15 days
B. 10 days
C. 30 days
D. 20 days
E. 60 days
92. If the counterfeit drug is the proximate cause of death
of the victim who unknowingly purchased and took the
counterfeit drug, the penalty to be imposed shall be:
A.
B.
C.
D.
E.
Life imprisonment
Fine of 500,000 to 5M Pesos
Fine of 100,000 to 10M Pesos
A & B Only
A & C only
93. The council of Pharmaceutical Education was
created for the implementation of RA 5921. This
council is composed of:
A.
B.
C.
D.
E.
Secretary of Education
BFAD administrator
Chairman of the Board of Pharmacy
A&C
AOTA
Other members are Undersecretary of Health Service, Dean of UP College of
Pharmacy, Deans of the Colleges of Pharmacy representing duly, accredited
private schools of pharmacy and a representative of a bona fide national
pharmaceutical organization of the Philippines.
94. If found guilty of neglect of duty, incompetence,
malpractice or unprofessional or dishonorable conduct,
after having been given the opportunity to defend
himself in an administrative investigation, the Chairman
or members of the Board may be removed by:
A. President of the Philippines
B. Chairman of the Council of Pharmaceutical
Education
C. BFAD administrator
D. PRC Comissioner
E. Civil Service Commissioner
95. Any person who shall be employed as detailman
by any pharmaceutical establishment shall be
required to register with the
A.
B.
C.
D.
E.
PRC
BFAD
Board of Pharmacy
DOH
Council of Pharmaceutical Education
96. Every prescription for external use filled in the
drugstore shall bear what label
A. Red label
B. White label
C. Red label showing in black ink the component
and the words “For external use only”
D. White label showing in red ink the word “For
external use only”
E. NOTA
97. The book kept for the purpose of recording the
sale of poisons shall be open at all times for the
inspection and shall be preserved for a period of at
least ____ years after the last entry
A. 1
B. 2
C. 3
D. 5
E. 7
98. RA 3720 was signed into law on:
A. June 22, 1963
B. June 22, 1969
C. June 23, 1969
D. July 22, 1969
E. July 22, 1963
99. Prescription of Dangerous Drugs are written in:
A. Duplicate
B. Triplicate
C. One copy
D. Four copies
E. NOTA
one original, 2 duplicates
( Original- pharmacist, 1 copy- patient, 1 copy- practitioner)
100. Head of the PDEA
A. Secretary of Health D. PNP Chief
B. Director General
E. BFAD Director
C. NBI Chief