ABIRD - Active Background Ion Reduction Device for nansopray ESI/MS What will the Active Background Ion Reduction Device (ABIRD) do for your nanospray-ESI MS system? ABIRD will: • Reduce background ion signal in full MS during nanospray- ESI analysis. • Isolate your instrument from variable spikes in lab air quality. • Enhance signal-to-noise ratios across a wide mass range. • Impart a consistent low level chromatographic baseline across full gradient. • ABIRD can improve the identification of proteins in complex low level protein mixtures.* ABIRD uses no supplied gasses, just eco-friendly high capacity chemical filters. ABIRD has been fitted to a variety of source and instrument combinations including Thermo Fisher, Waters, Bruker, Proxeon, New Objective, and Advion. * ultimate results are sample, laboratory environment and operator dependent. With this in mind, some of the top labs in the world use ABIRD on all their instruments. ABIRD OFF This is the typical ABIRD effect observed in an average lab on an average day. (Left hand panel) ABIRD off in the middle of this 5 minute chromatogram. 1 minute summed scans on the right; no ABIRD top, with ABIRD bottom. Thermo LTQ-Orbitrap, New Objective Picofrit column, more details if you ask. ABIRD ON ABIRD allows an ion trap to isolate peptides at a lower signal level, thus more PSMs were obtained from the same amount of sample. (Right hand panel) Without background ions, the ion trap fills more with interesting ions from peptides. ABIRD on a Q-Exactive with an Easy Spray source.