Histology Laboratories
Molecules to Systems
2003
Compiled by
James D. Jamieson, MD/PhD
Thomas L. Lentz, MD
No part of this image collection may be distributed outside of the
Yale University Intranet.
Acknowledgements
Sources of Micrographs, Diagrams and Figures
Alberts, B. et al. Molecular Biology of the Cell. 4th Edition, Garland Science, New
York, 2002.
Gartner, L. P. and Hiatt, J. L. Color Atlas of Histology, Williams & Wilkins,
Baltimore, 1994.
Kerr, J. B. Atlas of Functional Histology. Mosby, London, 1999.
Kessel, R. G. and Kardon, R. H. Tissues and Organs: a text-atlas of scanning
electron microscopy. W. H. Freeman, San Francisco, 1979.
Lentz, T. L. Cell Fine Structure. W. B. Saunders, Philadelphia, 1971.
Lodish, H. et al. Molecular Cell Biology. W. H. Freeman, New York, 2000.
Mizoguti, H. Color Slide Atlas of Histology. Nihon Shashin Shinbunsha, Tokyo.
Young, B. and Heath, J. W. Wheater’s Functional Histology. Churchill
Livingstone, Edinburgh, 2000.
Micrographs taken by George Palade, Marilyn Farquhar, James D. Jamieson,
Nicolai Simionescu, Maya Simionescu, David Castle, Thomas L. Lentz.
Web Resources
http://info.med.yale.edu/webpath/webpath.htm
Cushing Library Educational Software/Cell Biology/Several Histology Resources
Bone Laboratory
Adult Bone
Some Useful Terms
Compact bone = cortical bone
Trabecular bone = spongy = cancellous bone
Osteoid: Bone matrix not yet calcified.
Woven bone: immature bone with randomly arranged collagen
fibers. Produced when osteoblasts rapidly produce osteoid as
in fetal bone development; fracture repair (callus).
Lamellar bone: regular parallel bands of collagen. Woven bone
eventually remodeled into lamellar bone. The normal form of
bone in adults.
Trabecular bone
Compact bone
Volkmann’s canals
Lamellar bone
Haversian canals
Cortical Bone
Canaliculi
Haversian canal
Osteocytes
Osteon: Lamellar Bone
Osteocytes in Lacunae in Lamellar Bone
Trabecular Bone
Muscle
Trabecular Bone: XS Long Bone
Endosteum
Periosteum
Trabeculae
Marrow
Trabecular Bone
Fibrous layer
Osteoclasts
Cellular layer
Compact bone
Periosteum
Endosteum
Bone Marrow
Articular Surface of Long Bone
Collagen layer
Cartilage
Bone
Articular Surface of Long Bone
Bone Formation
Intramembranous Ossification
(No cartilage model; bones of skull)
Osteoblasts
Osteoclasts
Intramembranous Ossification: Fetal Skull
Osteoblasts
Osteoclasts
Intramembranous Ossification: Fetal Skull
Endochondral Ossification
(Ribs, long bones, vertebrae; cartilage model)
Endochondral Bone Formation
Epiphysis (E)
Diaphysis
Epiphyseal growth plates (GP)
Fetal Finger
Epiphysis
Epiphysis With Trabecular Bone
E
GP
Metaphysis
Articular cartilage
E
GP
M
D
Growing Tibia
Calcified cartilage
GP
Bone
Osteoid
Growing Tibia
Resting
Proliferation
Maturation
Hypertrophy
Zone of calcifying cartilage
Chondrocyte Growth Sequence
Calcified cartilage
Bone
Osteoblasts; osteoid
Development of Trabecular Bone
Bone Remodeling
Activation Resorption Formation Sequence
Howship’s lacuna
Osteoclasts
Osteocytes in new lamellar bone
Osteoblasts (OB)
Vessels in Resorption Canal
Osteoid
OB
Osteoid
Resorption Canal XS
Some pathology to think about.
Mammary Carcinoma Metastases to Vertebra
Callus at Fracture Site
New Bone at Fracture Site
Osteoporosis with Vertebral Collapse
Osteogenic Sarcoma/Osteoid