The Different forms of Iron There are two forms of bio-available Iron Natural Organic Heme Iron Iron bound to natural hemoglobin or myoglobin Synthetic iron from chemical supplements plants and dairy and otherwise chemically bond synthetic iron Fe++ Fe++ Organic Heme Iron vs Synthetic Iron Fe++ Fe++ Intestine Heme iron is easily absorbed with 5-12 times higher bio-availability than synthetic iron. Fe++ Fe++ Fe++ Fe++ Absorption 20 - 25 % Fe++ Fe++ Fe++ Fe++ Intestine Synthetic iron must be dissolved before uptake with low absorption and sideeffects due to reactive free iron remaining in the gut. Fe++ Fe++ Fe++ Fe++ Fe++ Fe++ Absorption 2 - 4 % Efficient and Well Tolerated • • • • Heme Iron highly efficient with low acid content in the stomach Heme Iron uptake is great with Medications as antacids and PPI Heme Iron will not irritate the gut as there is no reactive free iron Heme Iron will not cause oxidative stress in the body system. Absorption (typical) Side-effects (typical) 20-30% 20-25% 2-4% 2-4% Heme Iron Synthetic iron Equal to Placebo Heme Iron Synthetic iron FerroCare Organic Iron • 18 mg Heme Iron, Fe++ • Iron integrated hemoglobin • Dosage 1 tablet/day Synthetic Iron tablet • 100 mg synthetic iron, Fe++ • Ferrous fumarate, sulphate • Dosage 1 tablet/day 18 mg Heme Iron 20 - 25% uptake 100 mg synthetic iron 2 - 4% uptake 4.0 mg Fe++ absorbed equals to 3.0 mg Fe++ absorbed equals to 4.0 mg Bio-Available Iron 3.0 mg Bio-Available Iron