Insulin Pumps: A Better “Shot”at Diabetes Care The 32nd Annual School Health Conference Thursday, May 20, 2010 Overview • Epidemiology • Pathogenesis • Insulin Therapy • • • • • • • Importance of Control Insulin Types/ Delivery Systems Pump Basics Pump Brands Infusion Sets Pump Candidates Starting on a Pump • Hypoglycemia • Hyperglycemia • Case Scenarios Type 1 Diabetes Mellitus • Previously referred to as insulindependent or juvenile diabetes • Polygenic, multifactorial, autoimmune disease • Most commonly occurs in the young Epidemiology • In 2004, 3 million Americans were estimated to have type 1 diabetes. • There is a 3% increase in incidence per year. • Approximately 1 in every 400-500 children has type 1 Diabetes. • Diabetes is second most common chronic disease in childhood after asthma. Epidemiology • Peak ages at onset: 5-7 and early puberty • 30% of cases onset 18 - 40 years of age • There is a genetic association in regards to the risk of developing diabetes. Risk for Type 1 Diabetes By Family Member with Diabetes Pathogenesis of T1DM • T-cell mediated process directed at pancreatic cell. • Pancreatic islet cell destruction results in absence of insulin. • Absence of insulin causes chronic hyperglycemia. Natural History of Type 1 Diabetes Genetic Predisposition Immunological Abnormalities Normal Impaired insulin insulin release release Beta-cell Mass (% max) 100 Overt diabetes 50 “Honeymoon” period 0 Birth Time (years) What does insulin do? • Insulin is a hormone secreted by the -cells of the pancreas in response to rising glucose levels. • Insulin is a “key” that allows peripheral tissues to open and allow glucose to enter. What does insulin do? Absence of Insulin • Absence of insulin causes the body to act in fasting state, despite being fed. • Serum glucose cannot be used by peripheral tissues because of dependence on insulin. • Stimulation of hepatic glycogenolysis and gluconeogenesis cause further hyperglycemia. • All of the above cause serum glucose levels to exceed the renal threshold (180 mg/dl) and glucose is spilled into the urine. Glycemic Control in Type 1 Diabetes Changes in Diabetes Management The Effect of Intensive Treatment of Diabetes on the Development and Progression of Long Term Complications in Insulin Dependent Diabetes Mellitus The Diabetes Control and Complications Trial Research Group NEJM 1993 Sep 30;329(14):977-86. Diabetes Control and Complications Trial (DCCT) 10.0 9.5 9.0 8.5 Conventional Intensive Hemoglobin 8.0 A1c 7.5 7.0 6.5 6.0 Adults Adolescents Risks & Benefits of Intensive Diabetes Therapy (DCCT) • Decreased Risk – Progressive retinopathy – Microalbuminuria – Neuropathy (%) 60 40 60 • Increased Risk – Severe hypoglycemia (%) 300 Glycemic Control in Pediatrics • Controversy remains about the level of glycemic control that should be targeted for children despite the findings of fewer complications with better control. • Concerns exists given the high risk of hypoglycemia and what hypoglycemia can do to the developing brain. Glycemic Control in Pediatrics • Consensus Statement from the American Diabetes Association targets the following goals: Age Pre-prandial Bedtime / overnight (years) Blood glucose Blood glucose (mg/dl) (mg/dL) Hemoglobin A1C (%) <6 6-12 100 - 180 90 - 180 110 - 200 100 - 180 <8.5 (but >7.5) <8 13-19 90 - 130 90 - 150 <7.5 Diabetes Care 2009; 32: S13-S62. How is glycemic control achieved? Insulin Therapy Action Profiles of Insulins Aspart, glulisine, lispro 4–5 hours Plasma Regular 6–8 hours insulin NPH 12–16 hours levels Detemir ~14 hours Ultralente 18–20 hours Glargine ~24 hours 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 Hours Burge MR, Schade DS. Endocrinol Metab Clin North Am. 1997;26:575-598; Barlocco D. Curr Opin Invest Drugs. 2003;4:1240-1244; Danne T et al. Diabetes Care. 2003;26:3087-3092 How can insulin be delivered? •Draw up from vial and administer with syringe •Insulin pens •Insulin pumps Insulin via Syringe • Insulin is drawn from a vial into a 28-31 gauge insulin syringe • Used for all patients who are newly diagnosed with diabetes as insulin doses are being adjusted daily Insulin Pens • Doses are “dialed up” • Administer like insulin injection via syringe and hold down back of pen • Benefits: Faster than syringe injections • Drawbacks: Less fine tuning of doses due to increments and pre-mixed pens come in specified dosages (70/30 or 75/25) 3 Injections a day U/mL 100 Aspart, glulisine, or lispro NPHB NPH at bedtime L D 80 60 Normal pattern 40 20 0600 0800 1200 1800 Time of day B=breakfast; L=lunch; D=dinner 2400 0600 3 injections a day U/mL Aspart, glulisine, or lispro 100 B L D Levemir 80 60 NPH 40 Normal pattern 20 0600 0800 1200 1800 Time of day B=breakfast; L=lunch; D=dinner 2400 0600 4 + Injections a day U/mL Aspart, glulisine, or lispro 100 B L D 80 Glargine or Levemir 60 40 Normal pattern 20 0600 0800 1200 1800 Time of day B=breakfast; L=lunch; D=dinner 2400 0600 First Outcome Study of Pumps in Pediatrics Reduction to normal of plasma glucose in juvenile diabetes by subcutaneous administration of insulin with a portable infusion pump WV Tamborlane, RS Sherwin, M Genel, and P Felig NEJM 1979; 300:573-8 The Development of the Insulin Pump Autosyringe AS2C Used 50mL syringe Had only one basal rate No memory Slightly noticeable when worn NEJM 1979; 300:573-8 Barriers to Pump Use Pre-DCCT • • • • • • SIZE Technical Limitations of early pumps Fear of hypoglycemia Fear of weight gain Psychosocial Issues Lack of commitment to intensive therapy • Patients • Parents • PHYSICIANS Barriers to Pump Use Pre-DCCT Many pediatric endocrinologists were reluctant to use pumps to treat patients with type 1 diabetes. A lack of data about pump use in children was often cited. Therefore, studies on the benefits of pump therapy in pediatric patients were completed. Changes in HbA1c Levels 8.5 p=.89 (NS) 8 p = .03 7.5 Pump MDI 7 6.5 Baseline 4 wks 8 wks 12 wks 16 wks Average Pre-Meal Glucose Levels 230 P<0.001 210 MDI 190 CSII 170 150 130 110 90 Breakfast Lunch Dinner Bedtime Improved Control With CSII 8.5 DCCT Adol 8 7.5 HbA1c Pre 12 mos Recent 7 6.5 6 5.5 < 7 years 7-11 years 12-18 years Age Ahern, et al. Pediatric Diabetes 2002 Reduced Risk of Severe Hypoglycemia DCCT Adol 40 35 seizure or coma events per 100 pt yrs. 30 25 20 15 10 5 0 12 Months Pre-Pump 12 Months Pump Rx Glycemic control Pre and post pump therapy in children <7 years Pediatrics 2004;114:1601-1605 Improvement on Pumps Pediatric Diabetes 2006; 7 (Suppl 4) 15-19. Change in Hemoglobin A1c Pediatric Diabetes 2006; 7 (Suppl. 4): 20-24. Advances to Pumps • • • • • • • • Smaller size (roughly the size of a pager) Multiple basal rates Temporary basal rates Direct glucose entry from meter or continuous monitor Able to check history Reminders and alerts Ability to disconnect infusion sets Bolus wizard availability • Preprogrammed carbohydrate ratios and correction factors • Glucose targets • Duration of insulin action Pump Basics Pump Basics • External, programmable pump • Continuously delivers insulin via indwelling subcutaneous catheter • Requires input from wearer • About the size of a cell phone/pager • Operates on a AAA battery • Hold up to 300 units of insulin Pump Basics: Insulin Delivery • Uses only Rapid Acting insulin (NovoLog®, Humalog®, Apidra®) • Patient no longer uses long acting insulin • Insulin delivered in 2 ways – Basal – Bolus Pump Basics: Basal Rates • Continuous “background” level of insulin • Basal rates are programmed in units/hr • Pump breaks down hourly insulin delivery rate into drips delivered every few minutes Pump Basics: Basal Rates Background insulin released slowly throughout the day. Lantus or Levemir Pump 2:00 7:00 12:00 16:00 20:00 24:00 7:00 Time Basal insulin delivery from a pump provides a better and faster match for life’s needs Pump Basics: Temporary Basal Rate • Temporary adjustment to basal pattern • Set in response to change in usual activity – Exercise (lower the usual basal pattern) – Sick Day (increase the usual basal pattern) • Programmed by – Duration – % of Basal – Example: Temporary rate at 200% for 3 hrs • Pump automatically returns to usual basal pattern at completion of temporary rate Pump Basics: Bolus Insulin • “Burst” of insulin programmed at the time it needs to be delivered. • 2 Types of Boluses – Correction Bolus – Meal Bolus Correction Bolus • Dose of insulin given to “fix” a BG that is outside of target range • Dose is based on: – Correction Factor (pre-programmed in the pump) – Target BG (pre-programmed in the pump) – Actual BG (entered into the pump by the user) • Corrections should not be given more frequently than every 2 hours – Giving corrections more frequently risks “stacking” the corrections – “Stacking” causes low BG levels 4-6 hours later How to Calculate a Correction Dose 1. Need: Correction Factor, Target BG, and Actual BG 2. Subtract Target BG from Actual BG 3. Divide Answer from # 2(above) by Correction Factor Example: Correction Factor – 1 unit per 125 mg/dL Target BG – 100 mg/dL Actual BG – 295 mg/dL 295-100 = 195/125 = 1.6units Meal Bolus • Dose of insulin given to “cover” the carbs in a meal • Dose is based on – Total grams of carbohydrates in meal – Insulin to Carbohydrate ratio (I/C) • Designed to bring BG back to where it started – Pre-meal BG is 235 mg/dL – 2hr PP BG will be around 235mg/dL • Bolus must be given before meal to limit after meal increase in BG levels How to Calculate a Meal Bolus 1. Need: insulin to carb ratio, total # carbs in the meal 2. Divide total # Carbs by Insulin to carb ratio Example: Total # carbs = 95 grams I/C – 1 unit per 12 grams 95/12 = 7.9 units Carbohydrate Counting • Allows for more flexibility • Only grams of carbohydrate are counted • Insulin dose is varied based on amount of carb and blood sugar level • However, it is important to note serving size! What About Sugar? •Carbohydrates are carbohydrates no matter what the source of the carb is. •Table sugar, sweets, and candy will be broken down into glucose. •As long as someone with diabetes counts the carbohydrate they are eating or follows a prespecified amount of carbohydrates daily, it is okay to eat such foods. How Fat Affects Your Blood Glucose Level • Fat takes longer to empty from the stomach which delays the absorption of glucose into the bloodstream • This process can cause the glucose to rise in 4-6 hours, when the carbs are being absorbed, but there is not adequate insulin circulating to cover the carbs at that time • Glucose can stay high for quite some time after a high fat meal Advanced Bolusing Normal Bolus Normal bolus Whole bolus delivered now Basal Square Wave Bolus Square Wave Bolus Bolus delivered over time duration Dual Wave (normal + square) Percentage of bolus now and percentage over time duration Dual Wave Bolus Types of Bolus: Square Wave or Extended • Delivered gradually and evenly over an extended period of time • The peak is delayed and blunted, and the duration of action is lengthened • Delivery can range from 30 minutes to 8 hours Square Wave Delivery Square Wave Action 0 1 2 3 4 5 Types of Bolus: Dual Wave or Combination • A portion is delivered immediately (normal bolus) and another portion is delivered gradually (square wave bolus) • The initial 1-hour peak occurs but is diminished • There is a second delayed/blunted peak and a longer duration of action Dual Wave Delivery Dual Wave Action 0 1 2 3 4 5 Why Use Square Wave/Extended or Dual Wave/Combination Boluses? • With slowly digesting foods, normal boluses may peak too soon and stop working too soon • This can cause a glucose drop soon after eating, and a glucose rise several hours later Delivery Action 0 1 2 3 4 5 Basals And Boluses Bolus bolus basal Suspend pump for exercise Basal Rate A pump more easily matches the realities of daily life. Insulin Pump Brands • • • • • Accu-check Spirit One Touch Ping by Animas Deltec CozMore 1800 Insulet Omnipod Medtronic Revel x23 Accu- Check Spirit •Bolus based on BG •Holds 315 units •0.1 unit basal rates & bolus increments •Reversible display •Side mounted tactile buttons •Accu-Check Pump Configuration Software •IR (direct line) control from optional Palm PDA or smart phone •Database of 1,000 Calorie King foods in PDA One Touch Ping by Animas •Bolus can be delivered from One Touch meter up to 10 feet away •High contrast color screen for easy viewing • Smallest mainstream pump •Basal rate increment 0.025 u • Waterproof – 12 ft for 24 hrs • ezCarb meal bolus calculator •ezCarb stores 500 foods • ezBG correction bolus calculator • ezBolus shortcut to give bolus Deltec CozMore 1800 •Most features: HypoManager, Weekly Schedule, Missed Meal Bolus, Disconnect Bolus, Basal Test, Meal Maker with CozFoods, Therapy Effectiveness • Most flexible setup DISCONTINUED!!! • Direct BG entry from attachable Freestyle meter • 300 units • 0.05 unit basal and bolus increments • Accurate bolus calculations • IR download • Best for blind or visually impaired Insulet Omnipod •No tubing for easy wear • Automatic cannula insertion and priming • 200 units • Limited to 72-80 hrs use • Watertight • Controlled by PDM or smartphone • 1000 food database Medtronic Revel •Simple interface, less scrolling •Proprietary infusion sets • One Touch meter transmits BG directly •Bolus wizard (calculator for bolus doses) •Basal increments 0.025 units/hr •CareLink online software •CGM displays BG, 3 hr trend, trend arrow, and advance warning of lows and highs • Considered least accurate CGM for detection of lows Infusion Sets • Inserted under the skin in subcutaneous tissue. • Cannulas can be 6mm-17mm in length. • Can use Emla Cream prior to insertion. • Changed every 2-3 days. • Placed in abdomen or buttocks. Infusion Sets • Five varieties: o o o o o Self-contained (Omnipod) Slanted Teflon Straight-in Teflon Slanted metal Straight-in metal • Three connections: o Luer lock pumps: ~ 25 varieties o Paradigm: ~ 4 varieties o Omnipod: 1, auto-inserted Infusion Sets • Tubing may be disconnected without removing insertion site – Should be removed for swimming or bathing – Should be removed for contact sports – May be removed for other sports – If disconnecting for more than 2 hours, patients should check their blood sugars, reconnect, and give a bolus to prevent hyperglycemia How are the pumps worn? • Older patients will wear the pump on a clip which can be attached to a belt, pants, or in a pocket. • Pumps can also be left without a clip inside a pocket. • Special pump holders are sold which can be attached to the thigh or inside of bra to hold pump for discretion. • Younger patients may use pump packs. “Bad” Infusion Sets • Infusion set may go “bad” (pulled out, kinked, or blocked). • Because the pump only uses rapid-acting insulin if the site is not changed may end up with hyperglycemia or Diabetic Ketoacidosis. • So, if someone on a pump has a high blood sugar: 1- A correction is given through the pump. 2- Re-test blood sugar in 2 hours. If still high, then change infusion set and give injection of insulin. 3- Check urine for ketones. Who is a Pump Candidate? • • • • • Hemoglobin A1C of <8%. Testing blood glucose 4 times a day. Logs blood glucose. Counts carbs. Comes to clinic for follow up. Knows how to contact diabetes team. • Realistic expectations. Expectations Unrealistic Realistic The pump will cure my diabetes. I will feel better. I won’t have to test as much. I must test at least 4 times a day. I won’t have to log my blood sugar. I will have to log my blood sugar to adjust my pump settings. I can eat anything I want. I will have more freedom with my food choices if I bolus for my carb intake. My blood sugar will be perfect. I will have better control with fewer lows. It will be as very easy to start a pump. It will take time to learn and adjust to the pump. Starting on a Pump • Not started at diagnosis because: • Family needs time to cope with diagnosis. • Initial period of insulin resistance followed by possible honeymoon period. Meaning doses are undergoing daily changes at first. • If pump breaks, need to take shots. So, everyone needs to be proficient in taking shots. • Insurance issues. Starting on a Pump • Patient chooses pump and insurance coverage is sought. • Pump is shipped to family. • Family educates themselves in regards to pump via DVDs from pump companies, online tutorials, information packets. • Pump company sends trainer to home to initiate pump therapy. Baseline settings for pump sent by our group. Starting on a Pump • Blood glucose tested o Premeal (breakfast, lunch, dinner, bedtime snack) o 2 hour post meal (to assess carb ratio) o 12 a.m. and 3 a.m. (to assess basal rates • Family calls daily for~2 weeks for adjustments to pump settings. Pump Therapy • Patients are advised if blood sugar <70mg/dl to take fast acting sugar (4oz of juice, glucose tablets, candy). • If blood sugars are >300 twice or if >300 when waking up, insertion set must be changed. • Given only short acting insulin used, if tubing kinked or other problems risk of Diabetic Ketoacidosis if site is not changed. Pump Therapy • Then, patients are seen every 3 months for follow up in clinic. • Dose adjustments are made daily between 1-4p.m. for any patient who needs them. • 24 hour emergency line is available. The highs and lows of diabetes: Hypo and Hyperglycemia Causes of Hypoglycemia • Too much insulin • Inadequate food intake • Delayed meals or snacks • Exercise Symptoms of Hypoglycemia Moderate/Severe Hypoglycemia • • • • • • Lethargy Extreme weakness Unsteady Gait Combativeness Seizure Activity Unresponsiveness Treatment of Mild Hypoglycemia • Child is responsive and able to swallow • Blood sugar is <70mg/dL • Give 15 grams of FAST ACTING carbohydrate (3-4 ounces of juice, 3 glucose tablets) • Re-test in 15 minutes if persistence of symptoms see if blood sugar has risen. Treatment of Mild Hypoglycemia • Children who are able, can keep this treatment in the classroom. • Children should be assisted to the nurses office if necessary. • Children on insulin pumps may need less glucose for treatment. Over treatment of Hypoglycemia • More is not always better!!! • Over treatment of lows can cause hyperglycemia in the next 1-3 hours • If patterns of lows persist over days, family should be notified so insulin adjustments can be made. Treatment of Moderate/ Severe Hypoglycemia • Defined as requiring assistance of an adult to get treatment. • If child is able to sit and swallow, use juice or glucose tablets • If unable to swallow, use glucose gel first squirting the tube on the buccal mucosa. • If gel isn’t bringing the glucose up, then use call 911 and/or use glucagon. Glucagon • If altered level of consciousness or seizure activity consider glucagon use. • Mix powdered glucagon with diluent. • Draw mixture up in insulin syringe. • Administer subcutaneously. Prevention of Hypoglycemia • Child may need juice or glucose tabs before gym class or recess • If necessary, the pump may be disconnected for gym class or recess. • If recurrent lows inform the parents so they can call their clinicians to make dose adjustments. Causes of Hyperglycemia • Inadequate doses of insulin • Additional carbohydrates • Missed injection of insulin – glucose will be very high with ketones • Malfunctioning pump catheter – glucose will not respond to corrections given via pump, ketones may be present • Illness – ketones may be present • Lipohypertrophy – scar tissue at injection site Symptoms of Hyperglycemia Signs/Symptoms of Hyperglycemia and Ketonuria • • • • • • • Extreme thirst Increased urination Abdominal pain Nausea/vomiting Weakness Dizziness Labored breathing Hyperglycemia Correction • Correction can take 2-3 hours to normalize glucose • If glucose is not decreasing after 2 hours in a child on pump, then an insulin injection should be given • If the child feels okay he/she may • Return to class • Participate in gym • Sugar free liquids help with hydration • Contact Yale if treatment plan requires clarification (203) 764-6747. Hyperglycemia Correction Most patients will have personalized correction factors but the guidelines below can be helpful to determine a correction factor based on age. Age (years) Correction Factor (mg/dL) <3 225 4-5 200 5-7 150 8-11 125 Prepubertal and/or <13 Pubertal and/or >13 75 50 Treatment of Hyperglycemia with Ketonuria • Parents should be contacted immediately • Parents call Yale Pediatric Diabetes Clinic at (203) 764-6747 • Increased amounts of insulin will be required via injection. • Provide sugar free liquids. • Insulin is required even with vomiting and hypoglycemia with ketones. • No exercise with ketones Scenarios Scenario # 1 A student on a pump performs a routinely scheduled BG test just before lunch and the result is 61 mg/dL. The student is asymptomatic. What is the most appropriate action to take? Answer to #1 • Treat the low with 15grams fast-acting carbs • Send the child to lunch if feeling okay. • For children on pumps: consider bolusing ½ before heading to lunch and the other ½ after lunch Scenario # 2 13 yo student on a pump. Pre-lunch blood glucose is 302 mg/dL. The student boluses for both meal coverage and a correction. You ask the student to come back 2 hours later for a BG check. At that time, the BG is 290 mg/dL. What is going on? Answer to # 2 Most likely the pump site is no longer working. What actions should be taken? – Urine should be checked for ketones • If ketones are present, parent should be notified immediately – Student should (if able) change site and administer correction dose either via pump or via injection – If unable to change site, administer correction dose via injection and contact parent – If child feels well and no ketones present, may return to class (if unwell or ketones present, contact parent) – Repeat BG in 2hrs Scenario #3 A 6yo student is normally quiet and follows directions well. One afternoon during quiet reading time he starts to read out loud and states he is tired and puts his head down on the desk. What is most likely going on? Answer to # 3 Hypoglycemia Student may not have recognized earlier signs and symptoms of hypoglycemia and now we are seeing some neurological signs and symptoms Any sudden change in behavior is most likely due to hypoglycemia What actions should the teacher take? Answer to #3 • The teacher should have the child test his blood in the classroom and treat if his blood sugar is <70mg/dL. • If the child is unable to test in the classroom, he should be accompanied down to the nurse’s office to have his blood sugar checked. • If blood sugar <70mg/dL and the child is unable to swallow, consider using glucose gel or glucagon. Scenario # 4 A 9yo student has had BG levels > 250mg/dl for at least 3-4 days per week for the last 2-3 weeks before lunch. You have been giving correction doses of insulin each day at lunch. What is the best course of action for managing this patient’s BG levels? Answer to # 4 • Any recognizable patterns in BG levels require adjustment of insulin doses • Parent should be advised to contact the Yale Pediatric Diabetes Clinic for dose adjustments at (203) 764-6747. • In this case, either the basal rates may need to be changed or the breakfast carb ratio may need to be changed. • Some parents feel they need to wait for a visit for a dose adjustment – that is not the case especially w/ pediatric patients Scenario # 5 A 12yo student come into your office shortly after arriving at school and states she is not feeling well. She indicates that she did not eat much this morning because her stomach hurts and “everyone” at home has the stomach bug. She proceeds to vomit in the office What is/are the first steps to take? Answer to #5 • Check the BG (98 mg/dl) • Check for Ketones (moderate-large) • Contact the parent – This child needs to be monitored closely at home and the parent should contact our office right away – Additional insulin needs to be given to reduce the ketones but fluids/foods with glucose need to be given at the same time Emergencies we want to know about right away: Vomiting, persistent hyperglycemia, moderatelarge ketones, severe hypoglycemia Scenario # 6 One of the 6th grade teachers calls you at the beginning of the school day to let you know that a mother is bringing in cupcakes for the class. They will be having the cupcakes whenever the mother arrives. The teacher is concerned about the 11yo boy in her class who has diabetes. She called to ask your opinion about what to do. What is the best course of action? Answer to # 6 • Contact the parent to confirm that the student is okay to have a cupcake – – • Developmentally, this child does not want to be singled out Also important to learn that diabetes does not limit a child’s participation in school activities, it requires additional actions/safeguards Going forward – – – Teacher should notify you of any special events – well before they occur so that you may work w/ parent to accommodate the events Try to determine carbs of food to be eaten Grams of carbs should be estimated and entered into the pump. Yale Pediatric Diabetes William Tamborlane, MD Stuart Weinzimer, MD Eda Cengiz, MD Kristin Sikes, APRN Patricia Gatacomb, APRN Andrea Urban, APRN Kerry Stephenson, ARPN Kate Weymen, APRN Heather Mokotoff, APRN Pauline Rose, CDE Sylvia Lavietes, LCSW Jodie Ambrosino, PhD Jennifer Sherr, MD Ania Jastreboff, MD Anisha Patel, MD Michelle Vanstone, MD Valeria Benavides, MD Grace Kim, MD Amy Steffen Lori Carria Melody Martin Karen Esposito People with diabetes are NOT diabetic. They are living with diabetes. Thank you Questions????