COPD Disease not Disorder? Alyn Morice University of Hull HYMS AHM 2011 What is COPD? Asthma (eosinophilic bronchitis) Emphysema Chronic Bronchitis (neutrophilic bronchitis) 2010 Page 1 of 673! COPD Treatment Pathway Establish diagnosis of COPD in at risk population with history, examination and spirometry (FEV1/FEV ratio <70%) Establish severity of disease by FEV1 as % predicted Management of RISK FACTORS plus EDUCATION plus IMMUNISATION SMOKING CESSATION Lifestyle Advice Diet/Exercise Influenza vax (annual) Pneumococcal vax. Psychological Issues Pulmonary rehabilitation if functionally disabled – (Ensure treatment is optimised) PHARMACOLOGICAL TREATMENT Review at each step after one month before escalating treatment SHORTNESS OF BREATH prn short acting β2 agonist COUGH AND SPUTUM Tiotropium + short acting β2 agonist Tiotropium + long acting β2 agonist (LABA)* *salmeterol, eformoterol or indercaterol Tiotropium + combination LABA and inhaled corticosteroid (Seretide 500 accuhaler or Symbicort 200/6) Roflumilast + Tiotropium + short acting β2 agonist ( Weight loss) Tiotropium + combination LABA and inhaled corticosteroid (Seretide 500 accuhaler or Symbicort 200/6) Consider Palliative Care Referral in End Stage Disease M U C O L Y T I C S T H E O P H Y L L I N E Telemonitoring in COPD – the evidence base • Numerous pilot projects with accompanying evaluation reports; – Often exceptionally good results (e.g. COPD telehealth in SE Essex – 75% reduction in A&E attendances; 83% reduction in hospital admissions) – Often methodologically limited (e.g. before-and-after studies; small sample sizes) • Systematic reviews demonstrate that high-quality evidence base is still immature; – Bolton (2010): studies included were positive but of a lowquality – Polisena (2010): Telehealth interventions improved QoL and reduced hospitalisations Evaluation… • • Evaluation of first 3 months deployment (24 patients) showed: - Patient satisfaction generally very good - 68% reduction in n/e admission costs - net saving per month - achievement of £0.5m QIPP saving feasible Evaluation by Hull University – full year evaluation due Dec 11 Best health, best health care, a health service fit for the East Riding The East Riding Model IDENTIFY GP’s/NCT Patient at risk of deterioration • • Risk stratification identifies patient MDT agrees intervention REFER 1. Referral for telehealth intervention 2. Patient registered & unit installed MONITOR RESPOND 1. Monitoring Telephone patient 2. Alerts 3. Triage 4. Response Visit - within identified timescale Emergency Response Step up / Step down Community Beds Protocols for response in place: GP, NCT , specialist services, secondary care Best health, best health care, a health service fit for the East Riding Telemonitoring in COPD – How can it work? Telemonitoring in COPD – suggested mechanisms of action • It has been suggested that telemonitoring can support COPD patients by; – Providing reassurance and support Telemonitoring in COPD – suggested mechanisms of action • It has been suggested that telemonitoring can support COPD patients by; – Increasing knowledge of disease process and enhancing self-care – Providing reassurance and support Roger • • • • • 64 year old with chronic, severe COPD Housebound and anxious Frequently uses standby medication Frequent hospital admissions – anxiety rather than healthcare need Distrustful of clinicians due to previous experience After telehealth: • • • • Telephone contact to reassure Patient keeps diary of results and more knowledgeable about condition eg, trends/patterns More proactive about asking for help Reduced hospital admissions Best health, best health care, a health service fit for the East Riding Telehealth then... 14 Telemonitoring in COPD – suggested mechanisms of action • It has been suggested that telemonitoring can support COPD patients by; – Enabling earlier detection of exacerbation (e.g. due to reporting of worsening symptoms) – Increasing knowledge of disease process and enhancing selfcare – Providing reassurance and support The impact of frequent COPD exacerbations - more frequent attacks increase mortality Survival probability 1.0 n=304 0.8 A p<0.0002 0.6 B p=0.069 0.4 p<0.0001 C 0.2 0 0 10 20 30 40 Time (months) Soler-Cataluna JJ, et al. Thorax 2005;60:925–931 50 60 Group A: no exacerbations Group B: 1–2 exacerbations Group C: ≥3 exacerbations COPD patients with productive cough • More likely to have exacerbations Seemungal TA et al. Am J Respir Crit Care Med 98 • More rapid decline in lung function Vestbo J 1996, Kanner RA et al. Am J Respir Crit Care Med 01 • More likely to die early Prescott E et al. Eur Respir J 1995 Timing of symptoms: when was each symptom the most troublesome? 30 50 Breathlessness (n=1,769) 31.0 24.0 20 22.5 19.5 10 10.6 % of patients % of patients 40 Cough (n=1,433) 40 30 20 22.3 18.7 17.3 In the evening At night 14.9 10 0 0 On Later in the In the Waking morning afternoon 40 In the evening On Later in the In the Waking morning afternoon At night 60 Chest tightness (n=690) 30 28.8 25.9 25.4 25.5 20 16.7 10 % of patients 50 % of patients 48.9 40 30 20 10 0 Phlegm (n=1,551) 56.7 26.2 16.3 16.6 11.8 0 On Later in the In the Waking morning afternoon Partridge et al. ERS Vienna 2009 In the evening At night On Later in the In the Waking morning afternoon In the evening At night 19 HULL AIRWAYS REFLUX QUESTIONNAIRE Name: D.O.B:____________________________ UN: _________________ DATE OF TEST: Please circle the most appropriate response for each question www.issc.info Within the last MONTH, how did the following problems affect you? 0 = no problem and 5 = severe/frequent problem Hoarseness or a problem with your voice 0 1 2 3 4 5 Clearing your throat 0 1 2 3 4 5 Excess mucus in the throat, or drip down the back of your nose 0 1 2 3 4 5 Retching or vomiting when you cough 0 1 2 3 4 5 Cough on first lying down or bending over 0 1 2 3 4 5 Chest tightness or wheeze when coughing 0 1 2 3 4 5 Heartburn, indigestion, stomach acid coming up (or do you take medications for this, if yes score 5) 0 1 2 3 4 5 A tickle in your throat, or a lump in your throat 0 1 2 3 4 5 Cough with eating (during or straight after meals) 0 1 2 3 4 5 Cough with certain foods 0 1 2 3 4 5 Cough when you get out of bed in the morning 0 1 2 3 4 5 Cough brought on by singing or speaking (for example, on the telephone) 0 1 2 3 4 5 Coughing during the day rather than night 0 1 2 3 4 5 A strange taste in your mouth 0 1 2 3 4 TOTAL 5 SCORE_____________ /70 History of Cough Recording Woolf & Rosenberg,Thorax 1964:19;125 History of Cough Recording Woolf & Rosenberg,Thorax 1964:19;125 Waveforms showing acoustic events – Pre and post filtering unprocessed file processed file Cough counting in exacerbations of COPD •Day 1 546 coughs •Day 5 162 coughs 80 70 cough/hour 60 50 40 30 20 10 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 Time hours Future of telemonitoring in COPD 25