Hospital Outbreaks Allison McGeer Mount Sinai Hospital 416-586-3118 amcgeer@mtsinai.on.ca Outbreaks • Anything out of the ordinary • An increase in the occurrence of a complication or disease above the background rate • A statistically significant increase in the incidence of an infection Why are hospitals a problem? PATHOGENS – They concentrate virulent pathogens ACCESS – By hands on care, they allow transmission of these pathogens – By devices & parenteral therapy, they permit access HOSTS – They admit susceptible hosts (elderly, immunocompromised) – They make them more susceptible (chemotherapy, surgery) Hospital Outbreaks • 1 in 8 patients in Canadian hospitals acquire an infection as a result of their hospital stay – 5-10% of these are part of outbreaks • Rate: 1/10,000 admissions (Wenzel, 1981) 1/12,000 admissions (Haley, 1985) at least an equal number of “clusters” Outbreaks to be prepared for: • MRSA/VRE; S. aureus (nurseries); S. pneumoniae; GAS • P. aeruginosa, Serratia, Salmonella; resistant gram negs (ICU) • Legionella, Mycobacteria, C. difficile • Scabies • Candida, Aspergillus • Influenza, Hepatitis A/B/C, SREV, Adeno Outbreaks to be prepared for: • MRSA/VRE; S. aureus (nurseries); S. pneumoniae; GAS • P. aeruginosa, Serratia, Salmonella; resistant gram negs (ICU) • Legionella, Mycobacteria, C. difficile • Scabies • Candida, Aspergillus • Influenza, Hepatitis A/B/C, SREV, Adeno “Other” hospital outbreaks • E. coli O157:H7 in a salad served to patients, and in cafeteria • Legionella pneumophila in water supply • Pseudomonas aeruginosa from water/sinks • Ralstonia picketii from contaminated normal saline • Aspergillus fumigatus from an air conditioner • Serratia marcescens blood infections from propofol • Candida spp. from vacuum seals in equipment for preparation of TPN Hospital vs. Community Outbreaks • Reservoir/propagation – Reservoir is people (usually patients) – Propagation is person to person • We provide medical care to patients, as well as outbreak management – Easier to get medical/laboratory information – Differences between goals more evident Preparing for outbreaks Prevention • Physical structure • • • • Private rooms Adequate space – between patients, for cleaning Adequate ventilation Enough handwashing sinks, well-placed • Design in purchased equipment • • • • Glucometers Needleless IV systems Monitors for negative pressure rooms Machines for cleaning/disinfecting endoscopes/ endoscopes themselves • Cleaning/disinfection/sterilization • Adequate policies • Adherence to policies Preparing for outbreaks Prevention • Handwashing – Accessibility – Programs for compliance • Education – – – – Aseptic technique Handwashing Isolation precautions Surveillance/reporting Preparing for outbreaks • Detection – surveillance, awareness – culture, lab processing protocols – thresholds, time frames • Preservation of samples/isolates (typing) Preparing for outbreaks • Lines of communication – awareness among administrative staff – media relations • Funding – microbiology lab services • Policies for outbreak management Goals of outbreak investigation/management Outbreak types Investigation • Cause unknown • Control uncertain • Disease severe/many cases • Something to learn Management • Cause is known • Exposure/transmission known • Control measures effective • Small number/non-severe cases • “Nothing to learn” Outbreak investigation • • • • • • • • • Verify diagnosis Confirm the outbreak Develop a case definition Obtain descriptive epidemiology Develop a hypothesis Test the hypothesis Refine hypothesis/additional studies Implement control and prevention measures Communicate findings Hospital outbreak investigation • • • • • • • • Verify diagnosis Confirm outbreak Perform literature review/call experts Develop a case definition Obtain descriptive epidemiology Open lines of communication Implement control measures Consider definitive investigation Initial Investigation 1 Verify diagnosis 2 Confirm the existence of a problem - confirm the diagnosis - review existing data (surveillance records, interviews, microbiology records, charts) 3 Perform a literature review/ call experts - reservoirs, mode of transmission - things that went wrong Initial Investigation 4 Develop a case definition - microbiology other lab, radiology clinical signs/symptoms other (e.g. skin testing for TB) set time/place parameters 5 Identify, count, describe cases - line listing time/place person describe nature and severity plot epidemic curve Initial Investigation 6 Open lines of communication - consider media strategy - ensure all isolates/potential isolates are saved 7 Implement control measures - enforce existing measures - supplement Initial Investigation 8 Consider definitive investigation - formulate hypotheses - case control/cohort studies - cluster analysis Problem #1 • 3 candidemias on 14th level at MSH in one month • 14th level is gi medicine/general surgery – 68 beds – large oncology/IBD population – 25 pts per month on TPN Problem #2 Invasive GAS disease, LTCFs Number of cases 30 25 20 15 10 5 0 92 93 94 95 96 Year 97 98 99 2000 Other presentations/articles • http://www.idready.org/slides/03outbreakslides.pdf • http://www.dsf.health.state.pa.us/health/lib/ health/Outbreak_Investigation.ppt • http://www.wvdhhr.org/idep/PPTs/Outbreak Investigation.ppt • http://www.cdc.gov/ncidod/eid/vol4no1/rein gold.htm