Developing 3D Craniofacial Morphometry
Data and Tools to Transform
Dysmorphology
Richard A. Spritz, MD
Ophir Klein, MD, PhD
Benedikt Hallgrimsson, PhD http://www.easy-dna.com/printed-dna-art.html

• What is FaceBase?
• Previous Work
• Purpose
• Our Goals
• How to Participate – 3D Photos
• What will happen to the data we collect?

A group of research teams around the country studying facial development and facial characteristics.
www.facebase.org


• We studied genetic data and facial shape in
Tanzanian children
• We showed that 3D photos could distinguish altered facial development from normal

• Not sufficiently objective
Syndrome descriptions sometimes unclear
• Measurement Error
Manual measures are not very accurate or precise
• Limited Technology
Some 2D and 3D photos
Imprecise landmarking

• Library of 3D Facial Scans
• Diagnostic Aid for Physicians and Scientists
• “ Quantitative Science ”

1. Dense Surface Modeling
2. Geometric Morphometrics
• Automated facial landmarking
• Combine these analytical tools
• Apply to Clinical
Practice!
Spritz et al
Storage, William. Augustus Once And For All

• Sign up for an appointment
• Sign consent forms:
- I will go over the consent form with you
- HIPAA, Patient Bill of Rights
Medical Information Form
• Includes consent for “ data-sharing ” ;
De-identified photos and data to be deposited in NIH FaceBase “ Hub ” database.
May be shared to qualified researchers approved by NIH “ Data Access
Committee ” .

1. 4 Face views will be collected
2. Tie hair back
3. Sit still just like for a normal picture
4. About 10-20 minutes total
5. Each participant will be given an anonymous study number to preserve confidentiality

1. We will take your 3D photo
2. We will analyze the 3D image
3. We will place anatomic landmarks on the 3D image
4. We will analyze the 3D images of patients with a specific known syndrome to define features characteristic of each syndrome
5. We will develop methods to distinguish among different syndromes

• FaseBase2 is a research study, and is part of a larger international project
• We aim to improve how we diagnose genetic syndromes that include atypical facial development
• We need participants to take 3D Photos
• Let me know if you are interested and sign up for an appointment!

Phone Email/ Address Name
Richard A. Spritz, MD
Anschutz Medical Campus
University of Colorado, Denver
TEL 303-724-
3108
FAX 303-724-
3100 richard.spritz@ucdenver.edu
12800 E. 19th Ave., Rm. 3100,
MS8300
Aurora, CO 80045 USA
Ophir Klein, MD PhD
School of Dentistry
University of California, San
Francisco
TEL 415-476-
4719
FAX 415-476-
9513 ophir.klein@ucsf.edu
513 Parnassus Avenue
Box 0442
San Francisco, CA 94143-0442
Benedikt Hallgrimsson, PhD
Department of Cell Biology and
Anatomy
University of Calgary
TEL 403-220-
3060
FAX 403-283-
5666 bhallgri@ucalgary.edu
Rm G503, Health Sciences
Centre, 3330 Hospital Drive,
NW Calgary, AB T2N 4N1 elizabeth.beals@ucsf.edu
Elizabeth Beals, BS
Study Coordinator
University of California, San
Francisco
TEL 415-476-2985
CEL 925-285-5722