OBSTRUCTIVE JAUNDICE DR.JAMIL SAWAKED DEFITION OF JAUNDICE YELLOW DISCOLOURATION OF SKIN AND MUCOUS MEMBRANE Clinically evident when bilirubin is more than 2.5 mg/dl Normal bilirubin 0.2-1.2 mg /dl TYPES A PREHEPATIC HEPATIC POSTHEPATIC OBSTRUCTIVE OR SURGICAL HAEMOLYSIS ANATOMY ANATOMY A BILIRUBIN CYCLE BROKEN DOWN RED CELLS ARE REMOVED BY R.E.S. HAEMOGLOBIN SPLITS INTO HAEM &GLOBIN GLOBIN & CELL WALL PROTEIN GO DOWN TO AMINOACIDS THEY ENTER THE AMINO ACID POOL BILIRUBIN CYCLE CONTINUE HAEM SPLITS INTO IRON BILIRUBIN [pigments] & IRON STORED AS FERRITIN FOR REUSE BILIRUBIN IS NOT REUSED [GOES TO THE LIVER] COMBINE WITH GLUCOURINC ACID TO FORM THE CONJUGATED [ DIRECT ] BILIRUBIN [ WATER SOLUBLE ] Van den Bergh reaction [DIRECT] Alcohol added after van den Gergh [INDIRECT] HAEMOGLOBIN IRON +RBC WALL PROTEIN FERRITIN BILIRUBIN TO BE REUSED WATER INSOLUBLE GOES TO THE LIVER FOR CONGUGATION WITH GLUCOURINIC A.TO BECOME WATER SOLUBLE BLOOD URINE AMINOACIDS AMINOACID POOL URINE IN OBSTRUCTIVE JAUNDICE TEA COLOUR BILIRUBIN CYCLE DEEP JAUNDICE [OBSTRUCTIVE] CAUSES OF OBSTRUCTIVE JAUNDICE 1-STONES 2-STRICTURES; [BENIGN] 3-CA. HEAD OF THE PANCREASE 4-CHOLANGIOCARCINOMA 5-PERIAMPULLARY TUMOUR 6-PRESSURE FROM OUTSIDE;L.N.,M.SYN. 7-CHOLEDOCHAL CYST 8-PARASITES; FILLING THE LUMEN CAUSES IN THE LUNEN ASCARIS CLONORCHIASIS PARASITES HYDATID PAPILLOMATOSIS CHOLANGIOCARCINOMA STONE IS THE COMMONEST IN THE WALL:STRICTURES BENIGN STRICTURES MALIGNANT STRICTURES OUTSIDE THE WALL L.N. Stone in cystic duct MIRIZZI SYND HARTMANN`S POUCH stone HEAD OF THE PANCREASE ANY MASS OUTSIDE MIRRIZI`s syndrome BENIGN STRICTURES 1-BILIARY ATRESIA 2-IATROGENIC BILIARY SURGERY[commonest] GASTRECTOMY HEPATIC RESECTION LIVER TRANSPLANT 3-INFLAMMATORY;CHOLANGITIS , PANCREATITIS, SCLEROSINGCHOLANANGITIS. 4-TRAUMA 5-IDIOPATHIC 6-RADIOTHERAPY BILIARY ATRESIA NORMAL BILIARY ATRESIA CAUSES THE COMMONEST CAUSE STONE SLIPPING INTO THE BILIARY TREE IMPACTED STONE AT THE LOWER END OF C.B.D. ASSENDING CHOLANGITIS WITH LIVER ABSESSES CA. HEAD OF THE PANCREASE ENDOSCOPIC VIEW OF PERIAMPULLARY TUMOUR ORIGIN 1-DEUDENAL MUCOSA OR 2-C.B.D. OR 3-PANCREATIC DUCT CHOLANGICARCINOMA CHOLANGIOCARCINOMA LIVER METASTASIS C.B.D.STRICTURE SCLEROSING CHOLANGITIS •Associated with U.Colitis in 70% of cases •May lead to malignancy •Unknown aetiology •Symptoms of cholangitis •Treatment;Antibiotics • Or liver transplant Rosary beads شكل المسبحة SYMPTOMS PAIN YELLOW DISCOLOURATION SKIN &M.M. DARK URINE [TEA COLOUR] CLAY COLOUR STOOL لون الطحينية ITCHING FEVER IF CHOLANGITIS SUPERVENE LOSS OF APPETITE LOSS OF WEIGHT IN MALIGNACY SIGNS LOSS OF Wt. IN MALIGNANCY TOXIC IN CHOLANGITIS, [CHARCOT`S TRIAD,;PAIN, FEVER ,JAUNDICE] YELLOW DISCOLOURATION OF SKIN,M.M. TROISIER`S SIGN. VIRCHOW`S NODE TENDER R.U.Q.[IN CHOLANGITIS] COURVOISIER` LAW[IN CA.HEAD OF PAN.] ABDOMINL MASS ASCITES[IN MAIGNANCY] DEEP JAUNDICE [GREEN] [OBSTRUCTIVE] VIRCHOW`S NODE OR [TROISIER`S SIGN] BRUISING VIT.K DEF. 2,4,7,9,10.DEPEND ON IT COURVOISIER` LAW DISTENDED GALL BLADDER IN CA,HEAD OF PANCREASE ASCITES IN ADVANCED CA. HEAD OF PANCREASE INVESTIGATIONS C.B.C. DIFF., ESR. L.FT. *S.ALK.P.* PROTHROMBIN TIME S. AMYLASE K.F.T. ELECTRLYTES URINE ANALSIS * BILIRUBIN * STOOL ANALYSIS,;FAT,BLOOD. INVESTIGATIONS U.S. STONE DILATED CBD & STONE [US] Should be more than 6 mm C.T. DOUBLE BURRLE SIGN &DISTENDED G. PERIAMPULLARY TUMOUR ERCP SPHINCTEROTOMY STONE EXTRACTION BY BASKET STONE EXTRACTION BY BALLON ERCP C.B.D.STONE C.B.D. BIG STONE STENT STONE REMOVED C.B.D. STRICTURE C.B.D.STENT WITH GOOD FLOW CHOLANGICARCINOMA CHOLANGIOCARCINOMA E.R.C.P.FOR EXTRAHEPATIC CHOLANGIOCARCINOMA ENDOSCOPIC VIEW OF PERIAMPULLARY TUMOUR M.R.C.P P.T.C. PERCUTANOUS TRANSHEPATIC CHOLANGIOGRAM PEROPERATIVE CHOLANGIOGRAM T.TUBE CHOLANGIOGRAM DRAIN CHOLANGIOGRAM MANAGEMENT-1 CORRECTION OF THE DERENGED PARAMETRES ADMINISTRATION OF VITAMIN K ANTIBIOTICS MANNITOL PRE, INTRA and POSTOPERATIVELY TO PREVENT HEPATO-RENAL SHUTDOWN MANAGEMENT-2 1. STONE-SPHINCTEROTOMY 2.STONE-EXPLORATION OF C.B.D. 3.STRICTURE-RESECTION ANASTOMOSIS FOR SHORT STRICTURES 4.STRICTURE-STENT FOR SHORT AND LONG 5.CA.HEAD OF THE PANCREASE =EARLY-WHIPPLE`S OPERATION[PANCREATICO-DUODENECTOMY. =LATE-BYPASS SURGERY[CHOLECYSTOJUJENOSTOMY STENT FOR Ca. head of pancrease WHIPPLE`S OPERATION Pancreatico-duodenoctomy