INTRODUCTION TO THE AUTONOMIC NERVOUS SYSTEM STEVEN J. ZEHREN, PH.D. GENERAL REMARKS ABOUT THE NERVOUS SYSTEM STRUCTURAL DIVISIONS: CNS AND PNS CENTRAL AND PERIPHERAL NERVOUS SYSTEMS FUNCTIONAL DIVISIONS: SOMATIC AND VISCERAL NERVOUS SYSTEMS SOMATIC & VISCERAL NERVOUS SYSTEMS AUTONOMIC NERVOUS SYSTEM (= VISCERAL MOTOR SYSTEM) CLASSIFICATION OF FIBER TYPES (FUNCTIONAL COMPONENTS) IN CRANIAL* AND SPINAL NERVES Somatic (outer) Afferent (sensory) General (wide distribution) From skin — pain, temp., touch From skeletal muscles & tendons, ligs. of joints -- proprioception Special (restricted distribution) From retina – sight From inner ear – hearing & equilibrium General From internal organs – visceral reflexes, fullness of hollow organs, pain Special From taste buds – taste From olfactory mucosa -- smell General To skeletal muscles not derived from pharyngeal arches Special XXX – This category does not exist General To smooth muscle, cardiac muscle & glands Special To skeletal muscles derived from pharyngeal arches Visceral (inner) Somatic Efferent (motor) Visceral *Special components occur only in certain cranial nerves. STRUCTURE OF A TYPICAL SPINAL NERVE (T1 – L2) . TYPICAL SPINAL NERVE ( T1 – L2) TWO TYPES OF GANGLIA: SENSORY & AUTONOMIC COMPARISON OF SYMPATHETIC & PARASYMPATHETIC SYSTEMS SIMILARITIES 2 NEURON CHAIN INNERVATION OF THE SUPRARENAL MEDULLA NEURON #1 LIES IN CNS NEURON #2 LIES IN A GANGLION GANGLION GANGLION NEUROTRANSMITTER RELEASED AT GANGLION IS ACETYLCHOLINE GANGLION (ACH) GANGLION (ACH) DIFFERENCES THORACOLUMBAR (SYMPATHETIC) VS. CRANIOSACRAL (PARASYMPATHETIC) OUTFLOW Lateral horn of gray matter (intermediolateral nucleus) White matter Dorsal (posterior) horn of gray matter Ventral (anterior) horn of gray matter C5 T2 T8 Ventral median fissure L1 L2 S2 S3 LENGTH OF PRESYNAPTIC & POSTSYNAPTIC FIBERS NEUROTRANSMITTER RELEASED AT EFFECTOR ORGAN USUALLY NOREPINEPHRINE ACH AGGRESSIVE WHEN AN ORGAN RECEIVES A DUAL INNERVATION, THE SYSTEMS USUALLY HAVE ANTAGONISTIC PHYSIOLOGICAL EFFECTS INCREASE HEART RATE VEGETATIVE DECREASE HEART RATE AREAS OF DISTRIBUTION OF SYMPATHETIC VS. PARASYMPATHETIC FIBERS Sympathetic system reaches virtually all parts of the body (with the rare exception of such avascular tissues as cartilage and nails). Parasympathetic system distributes only to the head and neck, visceral cavities of the trunk, and the erectile tissues of the external genitalia (with the exception of the latter, it does not reach the body wall or limbs). PARASYMPATHETIC SYSTEM CRANIAL OUTFLOW (TO HEAD, NECK, THORAX, & UPPER ABDOMEN) PARASYMPATHETIC SYSTEM L. colic flexure PARASYMPATHETIC GANGLIA IN HEAD III --- CILIARY GANGLION IX --- OTIC GANGLION VII --- PTERYGOPALATINE GANGLION ---- SUBMANDIBULAR GANGLION X --- UNAMED GANGLIA IN NECK, THORAX & ABDOMEN “COPS” SACRAL OUTFLOW (TO LOWER ABDOMEN & PELVIS) PARASYMPATHETIC SYSTEM Pelvic splanchnic nn SYMPATHETIC SYSTEM GENERAL SCHEME OF SYMPATHETIC NERVOUS SYSTEM Splanchnic n. Rami communicantes . GRAY & WHITE RAMI COMMUNICANTES CONNECT TO SPINAL NERVES T1 - L2 (T1 – L2) WHITE RAMI = PRESYNAPTIC FIBERS GRAY RAMI = POSTSYNAPTIC FIBERS . ONLY GRAY RAMI COMMUNICANTES CONNECT TO SPINAL NERVES ABOVE T1 AND BELOW L2 Gray ramus comunicans (above T1 or below L2) _ _ _ _ _ _ Presynaptic sympathetic _________ Postsynaptic sympathetic Courses taken by presynaptic sympathetic fibers within the sympathetic trunks: 1. Ascend and then synapse 2. Synapse at level of entry Thoracic cardiac n. 3. Descend and then synapse Splanchnic n. Prevertebral ganglion. 4. Pass through sympthetic trunk without synapsing to enter a splanchnic nerve, and then synapse in a prevertebral ganglion SYMPATHETIC INNERVATION (TO PERIPHERY) SYMPATHETIC INNERVATION TO PERIPHERY (BODY WALL & EXTREMITIES) PERIPHERAL DISTRIBUTION OF SYMPATHETICS BETWEEN T1 & L2 SYMPATHETIC INNERVATION (TO HEAD) SYMPATHETIC SUPPLY TO HEAD Internal carotid n. Superior cervical ganglion External carotid a. & plexus Gray rami communicantes Middle cervical ganglion Vertebral ganglion Vertebral a. & plexus Cervicothoracic (stellate) ganglion Ansa subclavia SYMPATHETIC INNERVATION (TO THORACIC VISCERA) TO VISCERA (THORACIC) TO VISCERA (THORACIC) Paravertebral ganglion SYMPATHETIC SUPPLY TO LUNGS Thoracic cord segments T1-T5 Sympathetic trunk Pulmonary plexus Sympathetic fibers RED SYMPATHETIC SUPPLY TO HEART SYMPATHETIC INNERVATION (TO ABDOMINAL & PELVIC VISCERA) TO VISCERA (ABDOMINAL & PELVIC) Prevertebral ganglion TO VISCERA (ABDOMINAL & PELVIC) SPLANCHNIC N. (THORACIC, LUMBAR, & SACRAL) SYMPATHETIC SUPPLY TO ABDOMINAL & PELVIC VISCERA Celiac ganglia Greater and lesser thoracic splanchnic nn. Superior mesenteric ganglion Aorticorenal ganglion Least thoracic splanchnic n. Renal a. and plexus Inferior mesenteric ganglion 1st lumbar splanchnic n. 2nd and 3rd lumbar splanchnic nn. 4th lumbar splancnic n. Superior hypogastric plexus Hypogastric nn. (to inferior hypogastric plexus) END OF LECTURE