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Electrolytically modified functional
water (Kaqun) as a clinically
proven adjuvant treatment in
cancer patients
JÁNOS HUNYADI MD DSc
www.kaqun.eu
SANDOR KULIN MD
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What is KAQUN?
KAQUN is a special type of high oxygencontent water, which can be used as water
for therapy by drinking and/or bathing.
Technology used: electrolysis – nothing is
added to water
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Kaqun Hungária Ltd. has been using electrolysisproduced, high oxygen-content water since
2001 for the purpose of improving well-being,
in form of drinking and bathing therapy.
Last 10 years – 10 completed licensed scientific
study
IMMUNOLOGICAL
EXAMINATIONS (DEPARTMENT OF
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CYTOGENETICS AND IMMUNOLOGY
OF THE NATIONAL INSTITUTE OF CHEMICAL SAFETY)
●
●
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Percentage ratio of NK cells increased
The expression of CD25 surface marker increased
Increased reactive oxygen intermediates’ production
improves activity of neutrophil granulocytes
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The effects of KAQUN-water on patients
undergoing oncological treatment. A
randomized study
National Instiute of Oncology Budapest,
Hungary
100 patients with Melanoma Malignum stage IV
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To study the effects of Kaqun-water on patients undergoing
oncology treatment
Primary endpoints:
•
Radiation-induced dermatitis
•
Drug-induced dermatitis
•
Fitness and state of mind
•
Studying changes in exulceration
Secondary endpoints:
•
Changes in cutaneous manifestations of melanoma
•
Tumor response in complex oncotherapy of stage IV melanoma
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EFFECT ON DERMATITIS CAUSED BY
RT
3. days of 1st KAQUNtherapy
14. days of 1st KAQUNtherapy
Last day of 3rd KAQUN-therapy
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EFFECT ON DERMATITIS CAUSED BY
RT
Before KAQUN-therapy
After 3 days
After 7 days
After 10 days
(Kaqun) water on growth of human ovarian
carcinoma (A2780), and human cervix
carcinoma (KB-3-1) xenografts in SCID
mice.
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JÁNOS HUNYADI MD
Department of Dermatology,
University of Debrecen, Hungary
National Institute of Oncology, Budapest, Hungary
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Human ovarium
carcinoma cells
A2780
Human cervix
carcinoma cells
KB-3-1
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Cervix, control, 16 days
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Cervix, Kaqun 16 days
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Ovary, control 16 days
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Ovary, Kaqun 16 days
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Overall observations
•There is a remarkable difference between the two
investigated tumors. Growing of A2780 cell tumors
were in a 7 days delay compared to that of KB-3-1
cells
Four out of the 9 control mice died before
finishing the experiment, while only 2 out of the 14
Kaqun consuming groups did so.
•
Seventeen days after xenotransplantation the
volume of tumor was significantly smaller in Kaqun
and pre-Kaqun group in the case of both types of
tumors if the injected cells were 4 million.
•
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Growth of tumors after 4 X 106 A2780 tumor cell
transplantation was not detected in 3 of 14 mice in
the Kaqun treated groups, as opposed to control
mice (n=9) where growing tumors were detected in
each of them. .
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The most significant ovarian carcinoma inhibiting
effect was seen in the group of 2 X 106 A2780 cell
transplanted mice, when starting Kaqun water
consumption 14 days before xenotransplantation.
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In 2 X 106 KB-3-1 tumor cell
transplanted, Kaqun water consuming
animals in 5 out of 14 mice, a tendency of
tumor-regression was observed.
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Karuppaiyah Selvendiran, M. Lakshmi Kuppusamy,
Shabnam Ahmed, Anna Bratasz, Guruguhan
Meenakshisundaram, Brian K. Rivera, Mahmood
Khan and Periannan Kuppusamy: Oxygenation
inhibits ovarian tumor growth by downregulating
STAT3 and cyclin-D1 expressions. Cancer Biology &
Therapy 10:4, 386-390; August 15, 2010; © 2010
Landes Bioscience
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Physiological background of
KAQUN actions
Sándor Kulin MD
Orlando 2013
The key to
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Mitochondria
understanding:
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From his Nobel Lecture…
"Cancer, above all other diseases,
has countless secondary causes.
But, even for cancer, there is
only
one
prime
cause.
Summarized in a few words, the
prime cause of cancer is the
replacement of the respiration
of oxygen in normal body cells
by a fermentation of sugar… "
Dr. Otto H. Warburg
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ATP - Energy Membrane Potential
Electron
transport chain
Redox Signaling
Molecules
CO2 Production
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Membrane potential
•
Healthy cells: -70mV
•
Chronic inflammation: < -50 mV
•
Cancer: < -20 mV
•
Death: 0 mV
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•
•
•
•
•
•
Low membrane potential (below -20 mV) is a
prerequisite and a trigger of cell division.
Even healthy cells decrease membrane potential
below this threshold to perform cell division.
There is no cell division above this value!
Because of lack of energy, cancer cells can not
increase membrane potential - so they remain in
the division phase all the time
The lower the membrane potential the higher
the division rate!
There is a strong link between membrane
potential values and clinical malignancy.
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ATP - Energy Membrane Potential
Electron
transport chain
Redox Signaling
Molecules
CO2 Production
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Redox signaling molecules have regulating
effects on
o gene expression,
o apoptosis,
o cell growth,
o cell adhesion,
o chemotaxis,
o angiogenesis,
o immune reactions,
inflammation.
As the primary source of redox signaling molecules are
the mitochondria - in case of mitochondrial
dysfunction, all these functions are affected
o
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ATP - Energy Membrane Potential
Electron
transport chain
Redox Signaling
Molecules
CO2 Production
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•
•
•
•
In lack of mitochondrial activity there is no
CO2 production in cancer tissues.
In lack of pCO2, Oxygen remains attached to
Hemoglobin - inspite of the rich blood supply
of the tumor, cancer tissue remains hypoxic.
In lack of Oxygen, mitochondria can not be
restarted.
Any method that brings Oxygen into cancer
cells and restarts mitochondria is curative to
cancer.
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What do we know about KAQUN water?
• KAQUN has extra high stable dissolved Oxygen
•
•
•
•
content
Dissolved Oxygen reaches and enters cancer cells
without hemoglobin contribution
KAQUN triggers redox reactions in seconds as a
proof of mitochondrial activity
KAQUN triggers apoptosis as a proof of increased
cell energy level and increased membrane
potential
KAQUN triggers cell redifferentiation as a proof of
mitochondrial activity
Thank you
for your attention!
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Thank you
© 2013 EUROPEAN KAQUN
SYSTEM™
for your
attention!
ALL RIGHTS RESERVED
info@kaqun.eu
© 2013 EUROPEAN KAQUN
SYSTEM™
ALL RIGHTS RESERVED
info@kaqun.eu
www.kaqun.eu