雙離子性氟素材於傷口癒合之應用開發
Jheng-Fong Jhong(鍾政峰), Yung Chang (張雍),
2012/11/20
R&D Center for Membrane Technology and Department of Chemical
Engineering, Chung Yuan University, Taiwan (中原大學薄膜技術研發中心)
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雙離子性氟素材於傷口癒合之應用開發
General concept of wound healing
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Jheng-Fong Jhong
R&D Center for Membrane Technology
雙離子性氟素材於傷口癒合之應用開發
Membranes used in human body
 The performance of designed surfaces contact with human blood?
General Surface
Designed Surface
Hemocompatible Control
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Jheng-Fong Jhong
R&D Center for Membrane Technology
雙離子性氟素材於傷口癒合之應用開發
General synthetic systems
polyether
Widely used:
“Ideal anti-fouling candidates
Oligo(ethylene glycol) (OEG)-based materials
Cell membrane
Bio-mimetic
“Nature bioinert surface”
Sulfobetaine methacrylate (SBMA)
Poly(ethylene glycol) (PEG)-based materials
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Jheng-Fong Jhong
R&D Center for Membrane Technology
Plasma treatment
Atmospheric Pressure Plasma Jet (APPJ)
Flow rate:
10 slm
Ar
March box
Argon
Plasma jet
Sample
150W
< >
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RF power generator
Input power: 150 W
Characterization
 Without vacuum system
 Time reduction
X-Y axis controller
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Jheng-Fong Jhong
 Low energy consumption
R&D Center for Membrane Technology
雙離子性氟素材於傷口癒合之應用開發
Plasma induced surface modification
Ar+
F
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F
Jheng-Fong Jhong
F
R&D Center for Membrane Technology
雙離子性氟素材於傷口癒合之應用開發
Plasma induced surface modification
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+
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Biomimetic Interface
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Jheng-Fong Jhong
R&D Center for Membrane Technology
雙離子性氟素材於傷口癒合之應用開發
Animal wound healing test
2.5cm
2.5cm
1cm
1.5cm
1cm
SD rat
1.5cm
Age
8~10 week (420g)
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Jheng-Fong Jhong
wound
R&D Center for Membrane Technology
雙離子性氟素材於傷口癒合之應用開發
Platelet
RBC
Bacterial
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Jheng-Fong Jhong
R&D Center for Membrane Technology
雙離子性氟素材於傷口癒合之應用開發
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Jheng-Fong Jhong
R&D Center for Membrane Technology
Acknowledgement
We wish to express their sincere gratitude to
The Center-of-Excellence (COE) Program on Membrane Technology
from the Ministry of Education (MOE), R.O.C.
The National Science Council for their financial support.
CENTER for
MEMBRANE
T ECHNOLOGY
RESEARCH & DEVELOPMENT
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Jheng-Fong Jhong
R&D Center for Membrane Technology
THANK YOU FOR YOUR ATTENTION
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Jheng-Fong Jhong
R&D Center for Membrane Technology