Transformation of the ppCRRT to the ppAKI-RG
Stuart L. Goldstein, MD
Founder and Principal Investigator
The Prospective Pediatric CRRT Registry Group
The Prospective Pediatric Acute Kidney Injury Research Group
The ppCRRT Registry
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13 US Centers
Prospective observational CRRT cohort registry
2001 to 2005
370 patients entered
Patients aged 1 day to 25 years
Unrestricted industry funding
– Gambro, Dialysis Solutions Inc, Baxter, B Braun
• Jordan Symons, MD – Resident Artist
The Center for Acute Care Nephrology
The Founding Five
Bunchman
Brophy
Goldstein
Symons
The Center for Acute Care Nephrology
Somers
Askenazi D et al: PCRRT in Children < 10 kg (J Peds)
The Center for Acute Care Nephrology
The ppCRRT Registry
Co-Investigators/Authors
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Michael Somers
Michelle Baum
Pat Brophy
Jordan Symons
Tim Bunchman
Rick Hackbarth
Mark Benfield
David Askenazi
Michael Zappitelli
Geoffrey Fleming
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James Fortenberry
John Mahan
Deepa Chand
Francisco Flores
Kevin McBryde
Steven Alexander
Annabelle Chua
Douglas Blowey
Scott Sutherland
The Center for Acute Care Nephrology
The ppAKI-RG
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Multi-national research collaborative
Web-based registry under development
Interventional trials/FDA 510K planned
AKI studies, not limited to CRRT (no ECMO)
The Center for Acute Care Nephrology manages
contracts with sponsors and registry
• Sites receive PI, patient care and indirect costs
• Jordan Symons, MD, Resident Artist
The Center for Acute Care Nephrology
The Center for Acute Care Nephrology
Admission and Structure
• Signed consortium agreement:
– contact S. Goldstein (stuart.goldstein@cchmc.org)
• Each site with a signed agreement has a seat on
the research committee
• Anyone can bring a project to the ppAKI-RG and
they serve as overall project PI if approved by
the steering and research committees
The Center for Acute Care Nephrology
Current ppAKI-RG Sites
Center
PI
Alabama
Askenazi
Ann Arbor
Selewski
Atlanta
Paden
Boston
Somers
Cincinnati
Goldstein
Grand Rapids
Hackbarth
Iowa City
Brophy
Kansas City
Chadha
Kings, London
Deep
Montreal
Zappitelli
Nashville
Fleming
Palo Alto
Sutherland
Richmond
Bunchman
Rome
Picca
Seattle
Symons
Singapore
Peilin
St. Petersburg, FL
Flores
Sydney
Kennedy
The Center for Acute Care Nephrology