Once you have mastered H pylori gastritis and the atrophic gastritides, there are only a few more gastritides about which we know anything Lymphocytic Gastritis At low power, there is inflammation, mainly superficial. Check out the mess in the surface epithelium! Surface epithelial lymphocytosis with epithelial injury Same surface as in sprue Plasmacytosis in LP H pylori associated lymphocytic gastritis H pylori immunostain in an adjacent field Lymphocytic gastritis can produce polyps Some cases of lymphocytic gastritis have the giant folds and protein losing of Menetrier’s disease Small patches of lymphocytic gastritis like this pop up next to all kinds of things Lymphocytic gastritis next to a carcinoma Lymphocytic Gastritis Clinical Aspects • Endoscopic: nothing, polyps, giant folds • Clinical: nothing, sprue-associated, Menetrier’s syndrome, H pylori elsewhere FOCAL …ITIS Very, very common More common after search More common if there are residents The entire gut is at risk Almost never diagnostic Annoying The more foci the better! 2 tiny foci of gastric inflammation Multiple tiny foci One big focus Often mainly lymphocytes with PMNs, macrophages and epithelial damage Was found often in patients with Crohn’s Then it was found in patients with UC Given the name “focally enhanced gastritis” Every so often a granuloma or 2 may be part of focal gastritis Chemical (Reactive) Gastropathy At low power, the dominant change is the prominence of the PITS The high N:C resembles dysplasia PITS, PITS and more PITS, often serrated contours This change is an expansion of the proliferative zone (actually, the neck region, not the pits) in compensation for surface epithelial injury. This is very common in our practice. Most of the time, we do not know the cause. Stomach Small bowel Originally described on the gastric side of a gastro-enteric anastomosis, due to bile reflux Superimposed erosion (necrotic superficial mucosa In almost 20 year old studies of patients with chronic NSAIDs use. Not much change recently. Gastric erosions occur in 40-60% Gastric ulcers occur in 10-30% Duodenal ulcers occur in 5% Acute erosion—resembles acute ischemic injury