Tumanan-Mendoza BA, Dans AL, Villacin LL, et al. Dechallenge and rechallenge method showed different incidences of cough among four ACE-Is. J Clin Epidemiol. 2007;60:547-553.

To compare the incidence of cough among hypertensive patients taking cilazapril
(2.5-5 mg/day), enalapril (10 mg/day), imidapril
(10 mg/day) and perindopril (5 mg/day). This 6week double-blind randomized controlled trial enrolled 301 patients with a mean age of 54.5
years and average baseline systolic/diastolic blood pressure of 145/91 mm Hg.

Drug
Cough
Drop outs
Cilazapril (n=70)
16 (22.86%)
CI:14.42, 34.25
14
Enalapril (n=82)
18 (21.95%)
CI:14.22, 32.3
11
Perindopril (n=73)
6 (10.96%)
CI:3.71, 17.24
15
Imidapril (n=76)
10 (13.16%)
CI:7.18, 22.88
11
Total
(n=301)
50 (16.61%)
51
Drop outs included in analysis
Fisher’s exact test P value = 0.041
CI, confidence interval
Significantly lower incidence of cough with perindopril compared with other ACE inhibitors

This prospective, randomized, double-blind trial evaluated the rate of cough occurring with different
ACE inhibitors over a treatment initiation period of
6 weeks.
In this population, the incidence of cough in patients receiving perindopril was significantly lower than for other treatments, such as enalapril, cilazapril, and imidapril.
As blood pressure reduction was equivalent in each group, the author concluded that there is a difference between ACE inhibitors regarding the occurrence of cough.