Quality of Research Supported by SEARO in countries of the Region By Professor Ranjit Roy Chaudhury WHO-SEA ACHR BANGKOK 12 October 2011 1 PROPOSALS AND REPORTS REVIEWED BANGLADESH – 15 INDIA - 23 MYANMAR - 22 THAILAND - 06 A total of 66 projects and reports 2 CRITERIA FOR EVALUATION Relevance of project to the national health priorities Quality of design of proposal Whether ethical clearance requested Completion of project 3 CRITERIA FOR EVALUATION Presentation Publication of results at meetings of results of research Communication of results to government Policy change if any caused by research 4 QUALITY OF DESIGN Objectives of study Hypothesis Methodology Expected outcome 5 OVERVIEW OF ASSESSMENT FOR ALL FOUR COUNTRIES RELEVENCE OF PROPOSAL - High Relevance DESIGN – Many projects well designed - Always room for improvement ETHICAL CLEARANCE – Poor awareness - Need for improvement in all countries - 14 out of 66 proposals did not need clearance - Only 18 out of 52 proposals mentioned the need for approval 6 OVERVIEW OF ASSESSMENT WITH THIS LIMITED INFORMATION OF PROJECTS – A large number of projects had not been completed PRESENTATION OF RESULTS AT MEETINGS – This was low - Needs improvement PUBLICATIONS FROM RESEARCH – More emphasis needs to be placed on this - Generally poor COMPLETION 7 OVERVIEW OF ASSESSMENT CHANGE - IN POLICY Of the 22 completed projects results of 5 sent on to the government Change of policy in place from 4 of these Very encouraging 8 WEAKNESSES IN THE STUDY * In spite of all efforts proposals and reports of projects supported by SEARO could only be obtained from 4 countries * No proposals received from Indonesia, Nepal and Sri Lanka * Possible that information sent to SEARO was incomplete or not up to date * Every effort was made to obtain up to date information * Appears that improvement needed in information9 RESULTS • Presented country wise • Not meant to be a comparison between countries • Objective is to learn where strengthening is needed • Concentrate in future on these areas 10 PROPOSALS • • • 66 project proposals received 24 project details complete in all respects All projects were assessed according to information provided Proposals 24 Total Complete in all respects 66 11 BANGLADESH • 15 Proposals received • All were only at proposal stage • Assessment was therefore possible only for – - RELEVANCE - DESIGN - ETHICS 12 BANGLADESH RELEVANCE • All proposals were relevant to needs and prriorities of country • 5 out of 15 were highly relevant 13 EXAMPLE OF HIGHLY RELEVANT PROPOSALS • Prevalence on injury related disability in manikgunj district of bangladesh • Study to measure the intensity and incidence of catastrophic health care costs and impact on family budgets • Therapeutic efficacy of artemether in falciparum malaria 14 BANGLADESH DESIGN OF PROPOSALS • Quality of design found to be good in 14 proposals • Improvement in design possible 15 BANGLADESH ETHICAL CLEARANCE • 2 out of 15 proposals did not need ethical clearance • 8 out of 13 proposals needing clearance mentioned this in their proposal 16 PROPOSAL WHICH DID NOT NEED ETHICAL CLEARANCE Fiscal space assessment of Bangladesh health, nutrition and population sector 17 INDIA • 23 proposals were received 4 PROJECTS COMPLETED 11 8 PROJECTS ONGOING ONLY PROPOSALS 18 INDIA RELEVANCE • 8 proposals were found very relevant • 9 proposals were also relevant • In total 17 out of 23 were relevant to the needs of the country 19 INDIA Examples of high relevance studies • Validation of haemoglobin colour scale for haemoglobin estimation • Estimation of malaria disease burden in Jharkhand • Community based interactions study for cardiovascular risk reduction in Kerala 20 INDIA DESIGN • Well designed proposals - 7 • Average but acceptable design - 8 • Design poor and improvement needed 8 21 INDIA ETHICAL CLEARANCE • 17 out of the 23 proposals needed ethical approval • 4 proposals mentioned ethical clearance in proposal • Could be that clearance was taken later 22 INDIA Examples of proposals which did not need ethical clearance • Market study of alternatives of mercury measuring devices in health care in India • Feasibility study to develop healthy work place in the industrial settings in 23 INDIA • Presentation of results at meetings 2/11 studies presented • Publication of results No publications mentioned • Communication of results to government Results of 3 out of 11 completed projects Sent to government • Policy change Policy change expected in two 24 MYANMAR Proposals and requests • 22 proposals received • 9 were completed proposals • Assessment carried out on all aspects of 9 proposals 25 RELEVANCE • Proposals with high relevance - 9 • Proposals with average relevance -12 26 EXAMPLES OF HIGH RELEVANCE PROGRAMMES • Therapeutic efficacy of Myanmar traditional anti malarial drug (MTM-61-a) for treatment of uncomplicated p. Falciparum malaria • Antibiotic sensitivity monitoring of bacterial diarrhoeal diseases in central Myanmar 27 DESIGN • Proposals with good design - • Proposals with average design - 2 4 28 EXAMPLES OF PROPOSALS WITH GOOD DESIGN • Identification of different causal organisms of oral and respiratory diseases by saliva and sputum cytology • Research on utilization pattern of traditional medicine in a rural community of Pymoo and Naungeho 29 ETHICAL APPROVAL • Total proposals – 22 • Proposals needing clearance – 20 • Proposals which contained component of ethical clearance - 11 30 ETHICAL CLEARANCE NOT NEEDED Determination of in vitro anti TB activity of traditional medicine formulations and plants 31 RESULTS Presentation at scientific meeting - 1 The problem of MDR-TB in HIV patients 32 RESULTS Publications - Nil Findings sent to government - 1 • Study on assessment of physical and mental health of adolescents in various disorders • Change in policy - not yet but expected 33 THAILAND • Proposals received- 6 • Completed projects- 2 • Ongoing projects - 3 • Proposal stage - 1 34 RELEVANCE High relevance – 2 • Role of health technology assessment evidence in decision making - human papilloma vaccine • Continuing T B treatment upon being released from prison 35 DESIGN • Two proposals -very good • Four proposals - adequate 36 VERY GOOD DESIGN • Role of health technology assessment in decision making • An assessment of the thai national health research system 37 THAILAND Ethical Clearance • 4 out of 6 proposals needed ethical clearance • Only 1 proposal mentioned ethical clearance 38 PROPOSAL FOR WHICH ETHICAL CLEARANCE OBTAINED Continuing T B treatment after release from prison 39 ASSESSMENT • Completion of projects – 2 Presentation at meetings Results of both completed projects presented at meetings 40 ASSESSMENT * Publications no evidence of any publication Results communicated to government results of both projects sent to government Policy change policy change under consideration due 41 OVERALL ASSESSMENT Relevance – good Design - could be better Ethical clearance - very poor Completion - large number of projects not completed 42 OVERALL ASSESSMENT Presentation at scientific meetings – low Publications – low. More emphasis needed Presentation of results to government- not adequate Policy change - good reactions when results sent to government 43 RECOMMENDATIONS • Research methodology training courses • Create awareness of need of ethical clearance in research proposals • Presentation at meetings essential • Publications should be made part of the project 44 RECOMMENDATIONS • Summary reports to government to be always sent • Help needed to researchers for doing all this should be provided • Documentation and data storage to be improved • Regional Office and WR Offices could help in all three activities 45