Reporting on Scientific
Journal Articles
Jeremy Moore, M.A.
Senior Manager, Science Communications
American Association for Cancer Research
jeremy.moore@aacr.org
Why is Cancer Newsworthy?
Why is Cancer Newsworthy?
• Number 1 cause of death, surpassing heart
disease in 2010
Why is Cancer Newsworthy?
• Number 1 cause of death, surpassing heart
disease in 2010
• In the United States, it affects one in three
women and one in two men
Why is Cancer Newsworthy?
• Number 1 cause of death, surpassing heart
disease in 2010
• In the United States, it affects one in three
women and one in two men
• Consequences both biological and psychological
Why is Cancer Newsworthy?
• Money
Why is Cancer Newsworthy?
• Money
• Government Money
– NCI Budget, 2009: $4.96 billion
– NCI Budget, 2010: $5.1 billion
Why is Cancer Newsworthy?
• Money
• Government Money
– NCI Budget, 2009: $4.96 billion
– NCI Budget, 2010: $5.1 billion
Budget Request for 2011
$5.26 Billion
Why is Cancer Newsworthy?
• Money
• Private Money
Why is Cancer Newsworthy?
• Money
• Private Money
• Corporate and Philanthropic
Scientific Inquiry
“In fact I have not failed 1,000 times.
I have successfully discovered 1,000
ways not to make a light bulb.”
--Thomas Edison
Scientific Inquiry
• Cancer
Scientific Inquiry
• Cancer
• Out of control cell growth
Scientific Inquiry
• Cancer
• Out of control cell growth
• More than 200 diseases
Cancer
CURE?
Cancer
CURE
vs.
CONTROL
Cancer: The Scientific Questions
• Diagnosis
Diagnosis
• Bladder Cancer
• Pancreatic Cancer
• Ovarian Cancer
• Breast Cancer
• Colon Cancer
• Skin Cancer
Cancer: The Scientific Questions
• Diagnosis
• Screening
Screening
• Questions surrounding PSA, Mammography,
Colonoscopy
Sensitivity vs. Specificity
Sensitivity
• Correctly Identifying Who
Is Sick
Specificity
• Correctly Identifying Who
Is Not Sick
MicroRNA
“The discovery of MicroRNA can be equated with
the idea that we’ve known for years that cars
existed and only recently discovered they have a
transmission. It’s that fundamental.”
Philip Sharp, Ph.D., Nobel Laureate from M.I.T.
MicroRNA News from Annual
Meeting 2010
• miR-21 and miR-106a are associated with an
overall poor prognosis and that overexpressions
of miR-181b and miR-203 are associated with
poor outcomes in blacks for colorectal cancer
• MicroRNA-31 (miR-31) repressed specific tumor
suppressors and, therefore, may be a novel
pharmacologic target for lung cancer therapy
and chemoprevention.
MicroRNA News from Annual
Meeting 2010
• High levels of miR-21 were significantly
correlated with poor response to Herceptin.
DNA Methylation Levels
Cancer: The Scientific Questions
• Diagnosis
• Screening
• Personalized Medicine
Personalized Medicine
Cancer: The Scientific Questions
•
•
•
•
Diagnosis
Screening
Personalized Medicine
Prevention
Prevention
“At least half of all cancer deaths are preventable
by what we already know about healthy eating,
exercise, maintaining appropriate weight,
avoiding smoking and going for regular
screenings.”
Ernest T. Hawk, M.D., M.P.H.
Vice President of the Division of Cancer Prevention
and Population Sciences at The University of
Texas M. D. Anderson Cancer Center.
Prevention
• Healthy Living
Prevention
• Healthy Living
• Chemoprevention
Prevention
Scientific Inquiry
75 Clinical Trials
&
11 Systematic Reviews
Are Being Published Every Single Day
Bastian H, Glaszio P, Chalmers I, et al. (2010). Seventy-Five Trials and Eleven Systematic Reviews a Day: How Will We
Ever Keep Up? PLOS Med 7 (9): e1000326. doi:10.1371/journal.pmed.1000326.
Journals to Watch
• New England Journal of Medicine
Journals to Watch
• New England Journal of Medicine
• Journal of the American Medical Association
Journals to Watch
• New England Journal of Medicine
• Journal of the American Medical Association
• Cancer
Journals to Watch
•
•
•
•
New England Journal of Medicine
Journal of the American Medical Association
Cancer
Journal of Clinical Oncology
Journals to Watch
• Cancer Research
Journals to Watch
• Cancer Research
• Clinical Cancer Research
Journals to Watch
• Cancer Research
• Clinical Cancer Research
• Cancer Epidemiology, Biomarkers & Prevention
Journals to Watch
•
•
•
•
Cancer Research
Clinical Cancer Research
Cancer Epidemiology, Biomarkers & Prevention
Cancer Prevention Research
Journals to Watch
•
•
•
•
•
•
Cancer Research
Clinical Cancer Research
Cancer Epidemiology, Biomarkers & Prevention
Cancer Prevention Research
Molecular Cancer Research
Molecular Cancer Therapeutics
NEWS FLASH
• CANCER DISCOVERY
NEWS FLASH
• CANCER DISCOVERY
– Officially announcing next week
NEWS FLASH
• CANCER DISCOVERY
– Officially announcing next week
– Editors in Chief, Jose Baselga, M.D, Ph.D. and Lewis
Cantley, Ph.D.
NEWS FLASH
• CANCER DISCOVERY
– Officially announcing next week
– Editors in Chief, Jose Baselga, M.D., Ph.D., and Lewis
Cantley, Ph.D.
– Will be the premier venue for the publication and
broad dissemination of high impact research in all
areas of cancer research
NEWS FLASH
• CANCER DISCOVERY
– Officially announcing next week
– Editors in Chief, Jose Baselga, M.D., Ph.D., and Lewis
Cantley, Ph.D.
– Will be the premier venue for the publication and
broad dissemination of high-impact research in all
areas of cancer research.
– First papers will be published online April 2011
NEWS FLASH
• CANCER DISCOVERY
– Officially announcing next week
– Editors in Chief, Jose Baselga, M.D., Ph.D., and Lewis
Cantley, Ph.D.
– Will be the premier venue for the publication and
broad dissemination of high-impact research in all
areas of cancer research
– First papers will be published online April 2011
– In Print July 2011
THE ANATOMY OF AN ABSTRACT
• Conclusions, not titles
THE ANATOMY OF AN ABSTRACT
• Conclusions, not titles
• Goals
THE ANATOMY OF AN ABSTRACT
• Conclusions, not titles
• Goals
• Population Samples
THE ANATOMY OF AN ABSTRACT
• Statistics
– P Values, anything less than .05 is significant
THE ANATOMY OF AN ABSTRACT
• Statistics
– P Values, anything less than .05 is significant
– Hazard Ratios
– HR=1.23, 95% CI, 1.05-1.10
THE ANATOMY OF AN ABSTRACT
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KEEP IN TOUCH
Jeremy Moore
Senior Manager, Science Communications
Office: 267-646-0557
Cell: 609-519-0212
jeremy.moore@aacr.org
THANK YOU