SIMSAM EARLY LIFE Interdisciplinary research on early life exposure and health Coordinator: Anna Rignell-Hydbom Co-coordinator Jonas Björk Division of Occupational and Environmental Medicine, Faculty of Medicine Centre for Economic Demography, Lund University School of Economics and Management Department of Landscape Architecture, Planning and Management, Swedish University of Agricultural Sciences SIMSAM Lund • More than 100 publications based on registry, survey and biobank data co-authored by SIMSAM Lund participants. • In association to the programme 13 PhD students have defended their thesis. • Fourteen new PhD students have started their education within SIMSAM Lund • Post-docs have been recruited • Several courses, seminars and workshops • National and international collaborations SIMSAM Lund – example of articles Associations between gestational complications; gestational diabetes and preeclampsia and air pollution. Malmqvist E, Jakobsson K, Tinnerberg H, Rignell-Hydbom A, Rylander L. Environ Health Perspect. 2013;121:488-493 Background A number of studies have shown associations between maternal air pollution exposure and adverse birth outcomes. However; limited information exist for exposure to air pollution and pregnancy complications 81,110 women (singleton births) 1999-2005 were linked to individually assessed nitrogen oxides and traffic intensity. 1 599 cases of gestational diabetes, 2 370 cases of preeclampsia Emission and meteorological data National Road database Results NOx (µg/m3) OR Gestational diabetes OR Preeclampsia Quartile 1 (2.5-9) 1.00 1.00 Quartile 2 (9-14) 1.19 (0.99-1.44) 1.28 (1.13-1.46) Quartile 3 (14-23) 1.52 (1.28-1.82) 1.33 (1.17-1.52) Quartile 4 (over 23) 1.69 (1.41-2.03) 1.51 (1.32-1.73) Maternal smoking during pregnancy and daughters’risk of gestational diabetes and obesity Mattsson K, Källén K, Longnecker MP, Rignell-Hydbom A, Rylander L. Diabetologia 2013;56:1689-95. Background A study from Norway (the MoBa cohort) showed significant associations However: - Relatively high fraction of non-participants - Smoking data collected retrospectively Study design Inclusion criteria: - Women born 1982 or later who have had at least one child of their own. - Complete data on relevant variables (smoking, BMI, birth weight etc) - Total of 54 012 women for the final analyses. Gestational diabetes Crude OR (95% CI) Non-smokers (ref) 1 Adj OR (95% CI) 1 1-9 cig/dag 1.73 (1.33, 2.26) 1.62 (1.24, 2.13) >9 cig/dag 1.68 (1.25, 2.27) 1.52 (1.12, 2.06) Obesitas (BMI>30 kg/m2) Non-smokers (ref) 1-9 cig/dag >9 cig/dag 1 1 1.40 (1.32, 1.48) 1.65 (1.54, 1.75) 1.36 (1.28, 1.44) 1.58 (1.48, 1.68) Cognitive reserve and dementia – Dekhtyar, S., Wang, H-X., Scott, K., Goodman, A., Koupil, I., Herlitz, A. • Dementia is a debilitating process characterized by the loss of memory and cognitive function in old age • Variations exist in the extent of neuropathology required for dementia diagnoses • To explain the disjunction between the extent of brain damage and its clinical manifestation – RESERVE was suggested • Brain reserve: anatomical features of brain structure help tolerate more dementia • Cognitive reserve: innate intelligence and stimulating life experiences make brain networks more efficient • Cognitive reserve is measured by education or occupational complexity • Educational and occupational attainment have social and cognitive prerequisites • Early cognitive ability could be a better instrument for cognitive reserve • A life-course model of cognitive reserve in dementia is yet to be tested SIMSAM Lund – Courses and seminars • New courses on advanced topics – Family-based designs (Paul Lichtenstein, Johan Hallqvist, Brian d’Onofrio) – Developmental psychology in a life course perspective (Elia Psuoni, Ilona Kuopil) – Bias in observational studies – what can go wrong in Epidemiology? (Jonas Björk) – Collaboration with research schools at the FAS-centre MetaLund and CED at Lund University • Open seminars on methodological issues regularly – In collaboration with EpiHealth and FoU-centrum Skåne SIMSAM Lund – Open seminars • Registry-based randomized trials • Propensity scores • Introduction to DAGs • Analysis of cross-sectional data • Rasch analysis • Bayesian methods • Qualitative methods • Individual vs. population risk • Multiple imputation • Validation of the Cox model • Age-Period-Cohort modeling • ... Extensive and highly accessed collection of presentations available on-line Centre for Economic Demography EpiHealth Lund Uppsala Lund Network for PhD-students at SIMSAM Lund SIMSAM network • Phd student conferences MetaLund LU & LTH • Courses • Interdisciplinary projects SIMSAM Lund – Cohort inventory • Joint initiative with EpiHealth and FoU-centrum Skåne • Close cooperation with SND SIMSAM Lund – Cohort inventory (cont.) SIMSAM Lund – additional infrastructure initiatives warranted • Still too hard for researchers outside the “register-based research clusters” to use registry data – Ethics and legislation – Study design – Data access – Data management – Security issues – ... Consulting and data management facilities Knowledge transfer Courses Seminars Workshops Virtual and physical meeting place SIMSAM Lund Arena for new collaborations Common tools, routines and technical platforms Centre for interdisciplinary research based on registries and biobanks Tack Anna !! för det fantastiska arbete du gjort för oss dessa år