Pulse
Electroporation System
Onyx Medical Inc.
Various TDD Technologies
 Electroporation - Using short electrical modulated pulses of
high voltage to create transient aqueous pores in the skin.
 Iontophoresis – Using low voltage electrical current to drive
charged drugs through the skin.
 Sonophoresis – Using ultrasound to disrupt the stratum
corneum.
 Thermal energy – Using heat to make the skin more permeable
 Magnetophoresis - has been investigated as a means to
increase drug flux across the skin.
 Needle Free Injection - devices for “firing” molecules through
the skin at high velocity
Electroporation
 Non-invasive
 Alternative to mesotherapy
 Virtual mesotherapy or
without needles
 Painless procedure
 Introduction of drugs
 alternating current
 rearrange the structure in the
cells of the outer layer of skin
 Acts as a virtual syringe
 Changes direction (polarity)
continuously slowly
 Generating new pores
 Micro and macromolecules
 500,000 Dalton as collagen.
 800.000 Dalton as hyaluronic
acid
Electroporation
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For electroporation we need:
Membrane potential: 0.5-1.5 volts
Disrupt lipid layer
Open biological channels (aquous)
These channels stay open several seconds
Change polarity constantly
Background
The application of an electrical pulse momentarily
disrupts the cell membrane, allowing entry of
product.
When the pulse ceases, the membrane returns
to its original structure, leaving retained
product that has penetrated into the interior
of the cell in place.
Electroporation
 Electric doors called
biological channels
 Electric pulse changes
membrane polarity
 By slowly changing the
polarization we do not
cause electrolysis
 This disrupts lipid layer
Open Channels
Intercellular Communications
Cellular Penetration
Electroporation
 This effect lasts for seconds, therefore allowing the introduction of
substances.
 Hydrofilic and hydrophobic molecules penetrate at the rate of
1 g every 1 - 1.5 minutes.
 Continuous formation and appearance of biological channels
 Dramatically increases skin permeability.
Conclusion
 Electroporation is a process that uses high-voltage current to
make cell membranes permeable to allow the introduction of
new materials.
 In a practical sense Electroporation is opening a door that
allows us to insert “products” into the body.
Methodology
 Research documents 4 times
better results when you do an
exfoliation such as a peel or
micromicrodermabrasion
before Electroporation.
 This eliminates dead cells
from the Keratinic layer.
 This changes the skin
potential and makes it easier
to create biological channels.
Comparison with Microdermabration
Indications
 Introduction of substances for:
– Skin treatment
– Cellulite
– Flaccidity
– Wrinkles
– Obesity
– Collagen production
Contraindicaciones
 Pacemakers, heart valves
or other active implants.
 Epilepsy
 Pregnant women
 Immediately after Botox
 Skin outbreaks or on
infected tissue
 Metal plates or other
metal objects
 Ulcer or gastroenteritis
Wrinkles
Instruction:
Clean and dry skin the skin.
Exfoliate by microdermabrasion.
Optional: Use a micro roller after microderm.
Select Protocol
Power: 70% - 80%
Time of application: 20 – 25 minutes
Amount of product:
4 to 6 cc, divided into face, neck, and décolleté
Method:
Circular motion, soft and slow until completely absorbed
Frequency of session:
One session a week during five to six weeks
After one session every two week for one month
A monthly session as maintenance
Decolette
Instruction:
Clean and dry skin the skin.
Exfoliate by microdermabrasion.
Optional: Use a micro roller after microderm.
Select Protocol
Power: 70% - 80%
Time of application : 15 – 20 minutes
Amount of product :4 cc
Method:
Circular motion, soft and slow until completely absorbed
Frequency of session:
One session a week during five to six weeks
After one session every two week for one month
A monthly session as maintenance
Body Firming
Instruction:
Clean and dry skin the skin.
Exfoliate by microdermabrasion.
Optional: Use a micro roller after microderm.
Select Protocol
Power: 80% - 90%
Time of application: 15 – 20 minutes
Amount of product: 5 to 6 cc (depending if we have to
reduce or reaffirm)
Method:
Circular motion, soft and slow until completely absorbed
Frequency of session:
One session a week during six to eight weeks
After one session every two week for one month
A monthly session as maintenance
Breast Firming
Instruction:
Clean and dry skin the skin.
Exfoliate by microdermabrasion or gentle enzyme peel.
Select Protocol
Power: 80% - 90%
Time of application: 15 – 20 minutes
Amount of product:
3 - 4 cc
Method:
Circular motion, soft and slow until completely absorbed
Frequency of session:
One session a week during six to eight weeks
After one session every two week for one month
A monthly session as maintenance
Facial Rejuvenation
Instruction:
Clean and dry skin the skin.
Exfoliate by microdermabrasion.
Optional: Use a micro roller after microderm.
Select Protocol
Power: 70% + Face, 30-40% Lips
Time of application: 20 – 25 minutes
Amount of product: 5 to 6 cc, divided into face, neck, and chest
(also hands)
Method:
Circular motion, soft and slow until absorbed
Frequency of session:
One session a week for three to four weeks
After one session every two week for one month
A monthly session as maintenance
Localized Obesity
Instruction:
Clean and dry skin the skin.
Exfoliate by microdermabrasion.
Optional: Use a micro roller after microderm.
Select Protocol
Power: 85% - 95%
Time of application: 15 – 20 minutes
Amount of product: 6cc - 10 cc
Method:
Circular motion, soft and slow until absorbed
Frequency of session:
One session a week during six to eight weeks
After one session every two week for one month
A monthly session as maintenance
Cellulite
Instruction:
Clean and dry skin the skin.
Exfoliate by microdermabrasion.
Optional: Use a micro roller after microderm.
Select Protocol
Power: 85% - 95%
Time of application: 15 – 20 minutes
Amount of product: 6 - 10 cc
Method:
Circular motion, soft and slow until absorbed
Frequency of session:
One session a week during six to eight weeks
After one session every two week for one month
A monthly session as maintenance
ELECTROPORATION
ONYX MEDICAL INC.
1-800-333-5773
WWW.ONYXMEDICAL.COM