R&D
2013
RESEARCH & DEVELOPMENT UNIT WEST SUFFOLK HOSPITAL
Types of Investigation
Audit
Are we doing this to an accepted standard?
Contact the Audit dept.
R
&
D
Service Evaluation
How do we do this in the hospital at the moment?
Contact R&D@wsh.nhs.uk
Research
What is the best way of doing this?
Contact R&D@wsh.nhs.uk
2013
West Suffolk Hospital
is running 115 clinical trials
open to new subjects or in
follow-up.
RESEARCH & DEVELOPMENT UNIT WEST SUFFOLK HOSPITAL
Clinical Trials Phases I & II
Phase I (safety and tolerability) trials
which involve first human exposure
to a therapeutic agent.
Phase II clinical trials primarily are
intended to demonstrate whether or not
the new drug will provide any benefit and
whether that benefit is sufficiently better
than standard treatments to warrant
further development.
RESEARCH & DEVELOPMENT UNIT WEST SUFFOLK HOSPITAL
Clinical Trials Phases III & IV
• Phase III trial are randomized controlled, on
large patient groups. They are aimed at
being the definitive assessment of how
effective the drug is, in comparison with
current standard treatment. This is the kind
of study that patients from this hospital are
most often recruited into.
• Phase IV trials involve the safety
surveillance and ongoing technical support
of a drug after it receives permission to be
sold.
RESEARCH & DEVELOPMENT UNIT WEST SUFFOLK HOSPITAL
Research for Patient Benefit at
West Suffolk Hospital
The Research Question
Where do patients prefer to have their
intravenous cancer therapy?
In their own home?
In a General Practice?
In hospital?
The OUTREACH Trial: Dr M Moody
RESEARCH & DEVELOPMENT UNIT WEST SUFFOLK HOSPITAL
Medicinal Plants Senna alexandrina a source of senna
R&D UNIT WEST SUFFOLK HOSPITAL
Cancer Research at
West Suffolk Hospital
The Research Question
Chemotherapy
How much and for how long?
RESEARCH & DEVELOPMENT UNIT WEST SUFFOLK HOSPITAL
Research at
West Suffolk Hospital
The Research Question
The Genetic Analysis of
Multiple Sclerosis
Researcher Dr Paul Molyneux
Sponsor: Cambridge University NHS Foundation Trust
Funder: Wellcome Trust & National Institutes of Neurological
Disorders & Stroke
RESEARCH & DEVELOPMENT UNIT WEST SUFFOLK HOSPITAL
WSH Clinical Trials Unit (CTU)
• Investigation of a new blood
gas and electrolyte
analyser(pictured) in
partnership with Sphere
Medical
• For use in ITU and Cardiac
Surgery
RESEARCH & DEVELOPMENT UNIT WEST SUFFOLK HOSPITAL
WSH Clinical Trials Unit (CTU)
• A new facility for use by the
NHS & private sector
• To enable early phase
development of drugs &
devices
• The device pictured is a new
silicon chip that is being
studied here
RESEARCH & DEVELOPMENT UNIT WEST SUFFOLK HOSPITAL
Research at
West Suffolk Hospital
What is the best therapy for
advanced or metastatic prostate
cancer?
The STAMPEDE trial
Researcher Dr Cathryn Woodward
Dept. of Oncology West Suffolk Hospital
RESEARCH & DEVELOPMENT UNIT WEST SUFFOLK HOSPITAL
I have revised the slides for next year and included two cheesy Christmas cards from R&D.
Medicinal Plants Salix alba a source of Aspirin
R&D UNIT WEST SUFFOLK HOSPITAL
Research at
West Suffolk Hospital
The Research Question
What is the best treatment for
primary thrombocythaemia?
The PT1 trial
Researcher Dr Chitnavis
Dept. of Haematology West Suffolk Hospital
RESEARCH & DEVELOPMENT UNIT WEST SUFFOLK HOSPITAL
Research at
West Suffolk Hospital
Phase III Multicenter, Randomized, DoubleBlind, Parallel-Group, Placebo-Controlled
Study to evaluate the efficacy and safety
of Certolizumab Pegol in subjects with
adult-onset active and progressive
Psoriatic Arthritis
Researcher Dr David O’Reilly
Dept. of Rheumatology West Suffolk Hospital
RESEARCH & DEVELOPMENT UNIT WEST SUFFOLK HOSPITAL
Medicinal Plants Madagascar Periwinkle a source of Vincristine
R&D UNIT WEST SUFFOLK HOSPITAL
Let R&D take
the strain!
Contact:
R&D@wsh.nhs.uk
01284 712 790
RESEARCH & DEVELOPMENT UNIT WEST SUFFOLK HOSPITAL
Health Technology Devices (HTD)
The Health Technology Devices Programme aims to
stimulate and promote collaborative research that
contributes towards the development of new
technology which meets patient needs. The HTD
programme focuses on supporting the development
of new medical devices and healthcare
technologies that are capable of exploitation by the
healthcare industries. HTD Calls are invited and
handled through the HTD web portal at:
www.healthtechnologyportal.org.uk
RESEARCH & DEVELOPMENT UNIT WEST SUFFOLK HOSPITAL
Clostridium botulinum source of Botox
R&D UNIT WEST SUFFOLK HOSPITAL
West Suffolk Hospital
Research Aim
To ensure that all patients
and healthcare
professionals from all areas
of healthcare can take part
in and benefit from clinical
research
RESEARCH & DEVELOPMENT UNIT WEST SUFFOLK HOSPITAL
• Funding Programmes
• Programme Grants for Applied Research
• Programme Development Grant
• Funding Projects
• Research for Patient Benefit (RfPB)
• Research for Innovation Speculation and
Creativity (RISC)
• Invention for Innovation Programme (i4i)
• HTA Clinical Trials
• Health Technology Devices (HTD)
RESEARCH & DEVELOPMENT UNIT WEST SUFFOLK HOSPITAL
The First Clinical Trial
in 1747 James Lind compared six treatments for
scurvy (non-randomised open label)
Two patients were given cider
Two elixir vitriol
Two vinegar
Two sea water
Two spices, garlic & mustard seeds
Two oranges and lemons
Only the sailors given the fruit recovered
It took 40 years for the Admiralty to issue lemon juice
to all ships
RESEARCH & DEVELOPMENT UNIT WEST SUFFOLK HOSPITAL
Research Grants
Research for Innovation Speculation and
Creativity (RISC)
RISC is a response-mode funding programme
established to provide research of direct
benefit to users of the NHS in England.
The RISC programme is for potentially
paradigm-changing projects in Health
Services and Public Health Research.
http://www.nihr-ccf.org.uk/site/programmes/risc/default.cfm
RESEARCH & DEVELOPMENT UNIT WEST SUFFOLK HOSPITAL
HTA Clinical Trials
• The HTA programme commissions research
in three different ways:
1. By advertising standard calls for research
proposals that address specific topics
2. By advertising special calls for research
proposals that address themed areas
3. By funding HTA clinical trials and evaluation
studies that are proposed directly by
researchers.
http://www.hta.ac.uk/funding/index.shtml
RESEARCH & DEVELOPMENT UNIT WEST SUFFOLK HOSPITAL