Katie McAlindon and Tanya Khan
Agenda
 Concept and Process Background
 Report Content
 Writing/Style
 Grading
 Sign up
Concept
 Your group is a company placing a bid to provide a unit
operation in a process under construction
 You will design the most appropriate unit given the
conditions available in SuperPro
 Must be a feasible design (therefore you should consult
real companies and try to get real quotes etc)
 Detailed report will be submitted at a professional
standard
Project 1: β-galactosidase Production
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an intracellular enzyme produced by Escherichia coli.
mainly used in the utilization of cheese whey. More specifically,
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immobilized reactors convert lactose found in cheese whey to glucose and galactose, yielding a sweetened product
additive to ice cream, egg-nog, yogurt, and other dairy products
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Another application of b-Gal is in the treatment of milk products.
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This example analyzes a plant that produces 18,329 kg of b-Gal per year in 216 batches.
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produces lactose free milk products
PROCESS DESCRIPTION
Fermentation Section
 Fermentation media are prepared in a stainless steel tank (V-101), a continuous sterilizer (ST-101), a compressor (G-101)
and an absolute air filter (AF-101).
Primary Recovery Section
 The first step of the primary recovery section is cell harvesting to reduce the volume of the broth and remove
extracellular impurities;
Purification Section
 Next the product stream is purified by an ion exchange chromatography column (C-101) and then concentrated and
further processed.
Project 2: Monoclonal Antibody Production
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This example analyzes the production of a therapeutic monoclonal antibody using animal cell culture. The recipe
analyzed produces 19 kg of purified product per batch.
Infliximab is a monoclonal antibody against TNF-α.
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The SuperPro design is not specific to this antibody, but you can assume this is the antibody being produced for your
project
Approced by the FDA for treatment of psoriasis, Crohn’s disease, rheumatoid arthritis among other autoimmune
diseases
Works by binding to tumour necrosis factor alpha (a key part of the autoiummune reaction)
The exact mechanism is unknown
Cases programmed cell death of T-lymphocytes extressing TNF-α
A combination of a mouse and human antibody (artificial) (Chimeric monoclonal antibody)
Upstream Processing
 The upstream section is split in two sub-sections, the Inoculum preparation and the Bioreaction section.
Downstream Processing
 Bulk contaminants removed
 Protein concentrated
 Sterilized
 Further processed to final product
Monoclonal Antibody Flow Sheet
Our Expectations
 Professionalism and industry standard work are of
paramount importance
Our recommended Flow:
 Executive Summary (distilled up to the executive level, less
technical content, important conclusions)
 Tables of Contents and Figures
 Introduction to the purpose of the project, and your
specific unit
 Discussion of your design
 Conclusions and Recommendations
Executive Summary
 Brief summary of main conclusions (like an abstract)
 Written for the business world, not scientists
 Should focus on economic conclusions and design
 Sell your design
 1 page maximum
Introduction to your process/unit
 What does your unit do?
 How does it fit into the overall process?
 Why is it needed?
 Discuss flows in and out
 Give a purpose to your proposal
Discussion of your Design
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Pricing and sizing for appropriate capacity
Suppliers, quotes
Materials
Power requirements
Safety concerns (back ups, emergency shut off etc)
Environmental concerns
Waste streams (and destination of waste)
Human-power (automated vs manual operation)
Maintenance and cleaning
Inefficiencies or recommendations
This is not just stating facts, but comparing and
analyzing and proving that your design is the best
Conclusions and Recommendations
 Do not just restate the executive summary
 Can be more technical than ES.
 Draw together all the talking points about your design
and the conclusions that were made in each section
(i.e. power, safety, environments, costs)
 Provide recommendations
Unprofessional reports will not get a high grade (A)
Main Body
 Each section should have a clear purpose, discussion,
and conclusion
 Just a technical description is not enough, must explain
why we care
 Tangible and real equipment are important, but full
quotes should be in an appendix and referenced in your
main report.
 Irrelevant material will be penalized for lack of
professionalism
 Grammar and tense should be correct
 Consistency in style, format, voice
Figures and Appendices
 Figures should have a fully descript caption to describe
what we are seeing and how it is relevant
 Incomprehensible figures will be penalized
 Appendices
 Flow of report can be maintained by referencing quotes
in the appendix
 Appendices must be referenced in the main body and
relevant
 Unnecessary appendices will be penalized
Style and Formatting
 Should be at a level you would submit in industry
Marking Scheme
Style (/20)
 Includes professionalism, relevancy, grammar and typos,
consistency
Technical Content (/60)
 All design factors considered, supplier found and
recommended with good comparison and analysis,
prove your design
Conclusions (/20)
 Should be able to be understood without reading the
body
 Should be obvious and succinct
Sign up
 3 people per group, ONE group contact e-mail
 BE LEGIBLE!
 Location: Walter Light 714
 Time: To Be Discussed with you!
 Units will be assigned Friday afternoon through e-mail
 First come first serve on sign up list
An email from us will include:
 Your project SuperPro flow sheet and your assigned unit
 A copy of this presentation
 A SuperPro tutorial to do at your convenience