Regional Update
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Financial Report
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Governance Report
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Dr. Joel Pachter
Progressive MS Update
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Leukocytes enter the CNS during neuroinflammation
The blood-brain barrier is damaged during EAE/MS
Urgent Need to Find Solutions for
People with Progressive MS
•Large worldwide impact: about half of all
MS patients
•Finding solutions for progressive MS is
one of the top priorities for patients
•Currently paucity of effective DMT for
progressive forms of MS
•Every time another therapy is approved
for RRMS, a large proportion of our
constituents feel left behind
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Society Research Priorities
1.
To better understand the biological
basis for disease progression
2.
To dissect the mechanisms of nerve
damage and repair
3.
To identify risk and triggering factors
for MS
4.
To enable development of new or
improved rehabilitation techniques
5.
$46 million in current commitments to
progressive MS research
To grow the global MS research
enterprise
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Progressive MS Research Initiatives
1.
Over 100 investigator initiated research projects
2.
MS Outcomes Assessment Consortium
3.
Clinical Trials- MS SMART, SPRINT MS
4.
SUMMIT natural history and risk factors study
5.
Revision of Lublin-Reingold Clinical Course Descriptor
6.
International Progressive MS Alliance
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Mission
To expedite the development of effective disease
modifying and symptom management therapies
for progressive forms of multiple sclerosis
Better extravasating of hES-MSC
Where is MS research going?
 Novel drugs that act on “special” targets (e.g., CCL2)
Riluzole – sodium channel blocker
Amiloride – diuretic/neuroprotective
Ibudilast – anti-inlfammatory/neuroprotective
 Stem cell therapy with multifunctional “reparative” rather
“replacement” cells
Q&A
Medications & Treatments
• What FDA approved medications can we expect for
secondary progressive MS, and when?
• When will oral therapies be available for progressive
MS?
• I see your major research interests are blood brain
barrier & neuroinflammation. How do you feel about
these as treatment options? What do you suggest
we look for when searching for a doctor to treat this?
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Q&A
Stem Cells
• How soon are we going to see expansion of the
stem cell clinical trials?
• Are clinical trails for stem cells taking place in the
US?
• Will stem cell therapy become available and if so
how would this therapy help any type of MS?
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Q&A
Restoring Function
• What are the prospects for remylination?
• What progress has been made in RESTORING
function, especially in patients who've had MS 20
years?
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Q&A
General
• What is the difference between the different types of MS?
My daughter was recently diagnosed.
• As an undergraduate student starting to study MS, where
is the best place to start?
• Will there ever be a cure for MS?
• Is it common for Parkinsons Disease and MS to occur in
the same person? Is research being done around this?
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