Cardiovascular Medications PICU Resident Talk Stanford School of Medicine Pediatric Critical Care Medicine June 2010 Objectives After this lesson, the participant will be able to: • Define inotropy, chronotropy, lusitropy, and vasopressor. • List the determinants of BP and CO. • Describe the receptor/ mechanism of action of epi, norepi, dopamine, dobutamine, milrinone, phenylephrine, and nitroprusside. • List the major side effects of these medications. Definitions • Inotropy—the force of muscle contraction, most commonly cardiac muscle contraction • Chronotropy—affecting the heart rate • Lusitropy—relaxation function of cardiac muscle and chambers • Vasopressor—producing a rise in blood pressure through vasoconstriction • Why do we use vasoactives/ionotropes? To improve blood pressure • Why do we want to improve blood pressure? To improve oxygen delivery to tissues • What determines blood pressure? Where do cardiovascular medications work? Adrenoreceptors β1 receptors: α1 receptors: vasoconstriction Chronotropy Inotropy Vascular Smooth Muscle β 2 receptors: vasodilation Heart NO & PDE Inhibitors PDE3 Inhibitor: NO → guanalyl cyclase: vasodilation Chronotropy Inotropy Vascular Smooth Muscle PDE3 Inhibitor: vasodilation Heart The meds to choose from…. Dose: mcg/kg/min Mechanism /Therapeutic Effects Adverse Effects Epinephrine 0.01- 1 β1 ↑ HR, ↑ inotropy β2 vasodilatation α1 vasoconstriction ↑ SVR Arrhythmia ↑myocardial O2 demand Norepinephrine 0.01- 1 α1 vasoconstriction ↑ SVR β1 ↑ HR, ↑ inotropy Min β 2 effects Ischemic injury due to potent vasoconstriction ↑ afterload Dopamine <5 D1 diuresis, natriuresis, renal vasodilatation, (No proven benefit in preventing AKI or ↓ mortality) Arrhythmia ↑myocardial O2 demand 5 -10 β1 ↑ HR, ↑ inotropy >10 α1 effects vasoconstriction ↑ SVR Dobutamine 5-20 β1 ↑ HR, ↑ inotropy Mild β2, α1 antagonist vasodilation ↓ PVR, SVR Milrinone 0.25 -1 Hypotension Phosphodiesterase Inhibitor (PDE3 inhibitor): Myocardial : ↑ cAMP ↑contractility + ↑lusiotropy Arrhythmia Vasculature: ↑ cAMP vasodilatation ↓ SVR/PVR Phenylephrine 0.1-5 α1 vasoconstriction ↑ SVR Ischemic injury due to potent vasoconstriction ↑ afterload Nitroprusside 0.1-4 NO activates guanalyl cyclase (in vasc smooth muscle) ↑cGMP vasodilation Cyanide toxicity ↑ V/Q mismatch Arrhythmia ↑myocardial O2 demand Hypotension Summary of Key Points Dopamine Dobutamine Epinephrine Dopamine Dobutamine Epinephrine Norepinephrine Milrinone Decrease SVR Low dose Epi, Nitroprusside Milrinone Dobutamine Increase SVR High dose Epi Norepinephrine High dose Dopa (>10) Phenylephrine