Capsules for Drug Delivery
Fabrication of Polyelectrolytes on Soluble Templates
Stepwise Adsorption of Polyelectrolyte Molecules on Dissolvable Templates
Final Product:
The Polyeelctrolyte Capsule
Removal of the Core
Core Removal
0
1.4
12.7
19.8
a
b
c
d
20.6
26.9
72.6
382.6
e
f
g
h
Empty Capsules
Exclude Polymers
Monodisperse Capsules Obtained on
Melamin Templates
Scanning Electron Microscopy of Capsules
- Big and Small
m
10 m
m
10 m
m
10 m
Threeedimensional Replicas of Cells -
The Replica – a Polyelectrolyte Capsule
The Echinocyte
The Template
Adjusting the Permeability by Charging the Wall
10 min
m
10 m
1h
Permeation of Fluorescein through highly charged walls
4h
Filled Capsules
Crystals
everywhere
Only in
Capsules
PAH
The Building Blocks
PSS
Enzyme Encapsulation by Changing the Wall Permeability
5m
m
5m
m
A FITC-Labelled Protein is encapsulated
Optical sensors for pH
Labelled polymers
or Copolymers
Mikrocarriers
Microsensors
Microreactors
Catalysis on Nanopartiicles
or Polymeric
Catalysts
Tailored Polymers for
Adsorption und
Nucleation
Osmotic Swelling
And Shrinking
Layer Mechanics
Micromechanics
(a)
(b)
Capsules with Remains
(c)
Capsules filled by
Synthesis of
Polymers inside
Writing on Capsules
/
Reduction of Silver Ions
on
the Capsule Surface by Laser
5 µm
Scanning Force Microscopy – The Texture
Capsules with Oil inside
Coated Colloids – Surface Engineering
Reversibel Osmotic
Swelling and Shrinking