Teaching Bio-Transport Courses for
Undergraduate and Graduate Students
in ME and BME
Lisa Xuemin Xu, Ph.D.
Med-X Research Institute & School of Biomedical Engineering
Shanghai Jiao Tong University
Teaching Experiences
• 500 Level Graduate Course in ME at Purdue (1997-2002)
• Graduate Course in BME at Shanghai Jiao Tong Univ.
(2003-present)
• Undergraduate Course in BME at Shanghai Jiao Tong
Univ. (2005-present)
Bio-Heat Transfer Course (Undergraduate)
2 Credits, FALL Semester
Description:
This course is designed for biomedical engineering undergraduates with
necessary physics and mathematics background. A student achieving a
passing grade in this course shall be able to use the basic bio-heat and
mass transfer theories and method to analyze real biomedical problems,
be familiar with important applications of bio-heat transfer.
COURSE TOPICS
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Energy conservation and metabolisms
Basics of conduction, convection, radiation
Convection over body surface, sweating, respiration
Heat transfer to blood vessels
Thermal equilibration length of blood Vessel
Anatomy and description of human vasculature system
Temperature induced dynamic change of blood flow
Bio-heat Equation (Pennes Equation)
Temperature measurement and IR Detection of Breast
Cancer
• Application I: Tumor thermal treatment
• Application II：Cryo-preservation
Textbook and References
Text:
• Thermal Dosimetry and Treatment Planning, JC Chato, KD Paulsen,
RB Roemer, M. Gautherie (Ed.), Springer-Verlag Berlin Heidelberg
New York, London, Paris, Tokyo, Hongkong, 1990
Reference books：
• Heat Transfer in Medicine and Biology, A. Shitzer, Robert C.
Eberhart, Plenum Press, New York and London, 1985
• Heat Transfer Essentials, Latif M. Jiji, Begell House Inc. Publishers,
New York, 1998
Advanced Bio-heat and Mass Transfer
(Graduate Course)
3 Credits, Spring Semester
Description:
This course is for graduate students of biomedical engineering
specialty. The aim of this course is to introduce advanced bio-heat
and mass transfer problems and research fields. Upon completion
of this course, students are expected to understand mechanisms
underlying thermal physics interaction with biological systems, and
more importantly, to be able to simulate, analyze and evaluate the
transportation of heat and mass problems in this field.
Course Topics
• Review of basic concepts
• Bio-heat transfer equations：Pennes, WJ, ChenHolmes Equation, different models
• Biological responses to thermal stress
• Advanced bio-heat and mass transfer modeling
I： thermal treatment
II : cryobiology
• Micro and nano bio-heat and mass transfer
I : modeling
II : experimental techniques
III: applications
• Thermal physics in life sciences: tumor, energy and
environment
References
Papers:
Modeling
1. Harry H. Pennes (1948)
2. Chen-Holmes (1980)
3. WJ Model (1984-85)
4. Baish (1994)
5. New vascular models (1997-2002)
Thermoregulation and Physiology
Advanced Thermal Measurement Techniques
Latest Papers Related to Thermal Physics in Life Sciences
Books:
1. Avraham Shitzer, Robert C. Eberhart, Heat Transfer in Medicine and
Biology, 1985, Plenum Press, New York and London
2.Young I. Cho, Advances in Heat Transfer. Bioengineering Heat
Transfer 1992, Academic Press, INC
Cryosurgery of
Prostate Cancer
Thermally Targeted
Nano Drug Delivery
Applications of
Thermal Physics
Protein and Gene
Expression
Alternated Thermal
Treatment of Breast
Cancer
Discussion
• Bio-transport theories and experimental
techniques for translational research
(molecular diagnosis and treatment, nanocarrier delivery, tissue engineering etc.)
• New comprehensive text book integrating
bio-thermal physics, biomechanics,
biochemistry, and advanced measurement
techniques