By Martin Samaj Homeostasis • Blood, and tissue fluid derived from blood, flow around or close to all cells in the body • Blood and tissue fluid form the internal environment of the body • This internal environment is controlled and varies very little despite large variations in the external environment • The control process is called homeostasis • Homeostasis is maintaining the internal environment of the body between limits Parameters controlled by homeostasis • The human blood usually stays within certain limits for many physiological variables including: • Body temperature • Blood ph • Carbon dioxide concentration • Blood glucose concentration • Water balance The nervous system and the endocrine system are both involved in controlling the internal environment. The endocrine system consists of glands, which release hormones that are transported in the blood Endocrine and nervous system Negative feedback mechanism • The physiological changes that bring a value back closer to a set point are called negative feedback mechanism