Indy Bekerie
Annabelle Chu
Leeanna Hyacinth
Min Ye Shen
Kiet Vo
BME Senior Design 2011-2012
Preliminary Findings and Business Plan
Modular Incubation System
Delivering infants a better start
P: 212.854.6196 F: 212.854.8725
351 Engineering Terrace
1210 Amsterdam Ave
New York, NY 10027
|
IncuVive.weebly.com
P: 555.123.4568 F: 555.123.4567
123 West Main Street, New York,
NY 10001
|
www.rightcare.com
Executive Summary
• Company Overview
― Develop technology to combat infant hypothermia
that is viable for low-resource countries
― Advisors are leaders in the field of Biomedical
Engineering and renown neonatologists with
firsthand experience in the field
• Market
— NGOs, non-profits, and the hospitals of over 100
developing countries
• Business Model
— Capital equipment model
• Design and Development
— Overall Plan
— Innovative Designs
— Proof of Concept 1.0
•
•
Heating sources
Temperature sensors
• IncuVive Financial Projections and Key
Performance Indicators
P: 212.854.6196 F: 212.854.8725
P: 555.123.4568 F: 555.123.4567
351 Engineering Terrace
123 West Main Street, New York,
1210 Amsterdam Ave
NY 10001
New York, NY 10027
||
www.rightcare.com
Incuvive.weebly.com
Company Overview
• Our Technology
— Will produce the correct amount of heat,
maintain temperature
— Can be coupled with a crib and cover
— Incorporates accurate temperature sensors
— Utilizes an innovative feedback mechanism
and alarm system
+
• Advantages Over Present Solutions
— Feedback Mechanism
— Affordable, reliable
— Viable for low-resource countries
• Advantages Over Other Companies
— Few other companies targeting developing
countries
=
An innovative solution to
combat infant hypothermia
P: 555.123.4568 F: 555.123.4567
123 West Main Street, New York,
NY 10001
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www.rightcare.com
The Market
Market Strategies
• ~ 4 million annual infant mortality [3]
Target
– 18%-42% caused by hypothermia
» 720,000 to 1.68 million of neonate deaths can be
•
Uganda
•
Other developing
countries
prevented annually
• ~ 144 developing countries [1]
• In Uganda
– 80 per 1,000 live births [5]
Customers
• Ministry of
Health
• NGOs
• Donors
– 15 to 18 neonates suffering from hypothermia can be
saved
Consumers
• National • Sub-district • Other rural
and
hospitals
healthcare
Regional
facilities
Hospitals
Neonates
[3] UNICEF. Progress for children: a world fit for children statistical review. New
P:NY:
212.854.6196
F: 212.854.8725
York,
United Nations
Children`s
Fund; 2007
P: 555.123.4568
F:
555.123.4567
351 Engineering
Terrace
[5] Infant
mortality rate,
Uganda. Google.com/publicdata
www.rightcare.com
123 West Main Street, New York,
1210 Amsterdam Ave
NY 10001
New York, NY 10027
||
Incuvive.weebly.com
The Market
Competition
•
Van Hemel Baby Incubator (~ $450)
•
Medicine Mondiale’s Liferaft Incubator (~ $1,500)
•
General Electric (GE) incubators ($15,000-$40,000)
Risks and Obstacles
•
Secure funding for production
•
Partnership with the Ministry of Health and the NGO’s
•
Protection of Intellectual Property
•
Larger medical device companies
Our MIS Will
• Incorporate a reliable feedback
mechanism
• Revive current nonfunctional
incubators
• Convert available cribs to modest
incubators
P: 212.854.6196 F: 212.854.8725
P: 555.123.4568 F: 555.123.4567
351 Engineering Terrace
123 West Main Street, New York,
1210 Amsterdam Ave
NY 10001
New York, NY 10027
||
www.rightcare.com
Business Model
IncuVive in Uganda
• We plan to follow a capital equipment model.
• The National Medical Store will be our main purchaser of our MIS; however, we also plan to
sell to NGO and private hospitals.
• Each unit will be priced at $50 after subsidizations
Strategic Partnerships
• Partnerships with NGOs such as UNICEF, ECHO, and the Gates Foundation will help offset
production costs and help sustain a low margin operation.
• We will utilize partner distribution channels in order to quickly establish operations in new
markets.
P: 555.123.4568 F: 555.123.4567
123 West Main Street, New York,
NY 10001
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Business Model
Expansion and Distribution
• Our main source of income will come from market expansion.
• Our device will be assembled locally and transported by a third party.
• After setting up distribution in Uganda we plan to immediately expand into surrounding
countries.
www.infoplease.com/atlas/country/uganda.html
P: 555.123.4568 F: 555.123.4567
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Short Term Plan
December
2011
• Proof of Concept
completed
• Finalize
preliminary
prototype idea
January
2012
March
2012
May
2012
• Start first prototype
• Start circuitry and
code for feedback
system
• Complete
construction and
testing of first
prototype on
animals
• Test durability,
power efficiency,
feedback/fail-safe
mechanism
• Start second
prototype
• Finish second
prototype
• Complete
integrated heating
unit and feedback
mechanism
• Apply for IRB
approval for field
testing in Mulago
Hospital, Uganda
P: 555.123.4568 F: 555.123.4567
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Design Ideas
Heating Mat + PCM
Feedback System
• Monitor and display temperature of
either mat or environmental
temperature
• Monitor and display temperature of
infant
• Automatically adjust heat setting to
maintain infant’s temperature in the
normal range
• Alarm if abnormal temperature
readings (too high or too low)
• Automatic shut off if temperature is
too high to prevent overheating
P: 555.123.4568 F: 555.123.4567
123 West Main Street, New York,
NY 10001
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Design Ideas
Space Heater
Feedback System
• Monitor and display temperature of
either mat or environmental
temperature
• Monitor and display temperature of
infant
• Automatically adjust heat setting to
maintain infant’s temperature in the
normal range
• Alarm if abnormal temperature
readings (too high or too low)
• Automatic shut off if temperature is
too high to prevent overheating
P: 555.123.4568 F: 555.123.4567
123 West Main Street, New York,
NY 10001
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www.rightcare.com
Design Ideas
Warm Water Pump
Feedback System
• Monitor and display temperature of
either mat or environmental
temperature
• Monitor and display temperature of
infant
• Automatically adjust heat setting to
maintain infant’s temperature in the
normal range
• Alarm if abnormal temperature
readings (too high or too low)
• Automatic shut off if temperature is
too high to prevent overheating
P: 555.123.4568 F: 555.123.4567
123 West Main Street, New York,
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Decision Matrix
Methods of Heating
Heater
CRITERIA
Affordable
Portable
Durable
Easy to Maintain
Intuitive, Easy to Use
Sterilizable, Easy to Clean,
Diminishing Contamination
Low Power (e.g. runs on
batteries >= 24 hrs)
Preferably made with materials
available in Uganda
High Infant Visibility
Comfortable
Safe
Heating Pad
Value
400
4
300
3
180
2
200
2
210
3
Warm Water Pump
Value
200
2
200
2
180
2
200
2
140
2
WEIGHT
100
100
90
100
70
Value
300
300
270
300
210
3
3
3
3
3
100
300
3
300
3
200
2
70
210
3
350
5
210
3
20
60
3
40
2
60
3
90
80
100
totals:
270
240
300
2760
3
3
3
33
270
240
300
2790
3
3
3
33
180
240
200
2010
2
3
2
25
P: 555.123.4568 F: 555.123.4567
123 West Main Street, New York,
NY 10001
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•
•
Use phase change material (PCM) between
the neonate and the heating unit to prevent
burns
Maintain the baby at a temperature of about
37 °C while heating unit is off
PoC- Saline Bag Control
Methods
• A bag of saline with a thermometer inserted was
heated to 37 °C in a water bath. The saline was
placed on an inactive mat and allowed to cool down.
• The temperature of the saline was recorded every
minute with a calibrated thermistor inserted into the
saline until the temperature dropped to 34 °C
P: 555.123.4568 F: 555.123.4567
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PoC- Phase Change Material (PCM)
Results
Methods
• The PCM was activated in a microwave, then placed
on the inactive mat with thermistors placed at specific
locations.
• Meanwhile a bag of saline was heated to 35 °C in a
water bath and placed on the PCM.
• The experiment was repeated with thermistors.
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Saline on PCM with
Heating Mat
Saline on PCM
Conclusion
•
•
•
The PCM cannot raise the saline’s temperature
to 37 °C
The PCM can only maintain the saline’s
temperature above 35 °C for about one hour
with no external heat supply
Other insulating materials
P: 555.123.4568 F: 555.123.4567
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Temperature Sensors
Water Bath Temperature
Red spirit
NTC
21.1
19.85
42
40.95
36.8
37.79
34
35.18
LM34
21.21
42.63
37.65
34.78
Digital
--43.7
38
34.9
Left Armpit Measurement Approximating Body Temp.
Red spirit
Oral Reading
NTC
LM34
Digital
w/ Digital
34
34.31
35.08
35.5
35.9
34
34.51
35.31
35.7
36
34.2
34.77
35.64
35.8
36.1
34.2
35.02
35.73
35.8
36.2
34.2
35.15
35.96
36
36.2
34.2
35.17
35.98
36
36.2
Ambient Temperature
Red spirit
NTC
20.0
19.95
20.0
19.69
20.0
19.76
LM34
21.14
21.03
21.05
Red spirit
Thermistor
(NTC)
Model
Range ˚ C Accuracy ˚ C Price/unit
305 mm
White, Red
spirit filled -20 to 150
1.5
$5.15
Negative
Temperature
Coefficient
----~$0.25
Integrated
Circuit
(LM34)
LM34CAZ
Digital
2210DR
−40˚ to
110˚
32.0 to
43.9
± 0.25
± 0.1
$8.33
$10.00
Most viable for
•
•
•
Water: LM34
Skin: Digital*
Ambient: NTC
Digital
-------
Red spirit
P: 555.123.4568 F: 555.123.4567
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Long Range Plan
Design and build 1st
and 2nd prototype
Product Selection
Proof of Concept testing
Apply for funding and
grants and
start manufacturing
Continue R&D
Build final prototype
Develop extensive rapport
with NGOs, WHO, UNICEF
Initiate first assembly
station in Uganda
Continue development
of new products
P: 555.123.4568 F: 555.123.4567
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Financial Projections
Phase I
$ in thousands
2012
# of units ($)
0
Unit Sales ($50/unit)
0
Funds from NGO
500
($50/unit) and
Revenue ($)
500
R&D ($)
0
Internatiional
0
Device Approval ($)
Material cost ($)
150
Production Cost ($)
350
Wages ($)
0
Transportaton ($)
0
Total Cost ($)
500
Net Income ($)
0
2013
0
0
Phase II
2014
10
500
2016
300
15000
Phase III / Phase IV
2017
2018
2019
500
1000
1500
25000
50000
75000
2015
150
7500
2020
2000
100000
2021
2500
125000
0
3500
10500
18000
28000
53000
78000
103000
128000
0
1000
4000
700
18000
700
33000
800
53000
900
103000
1000
153000
1100
203000
1350
253000
1500
2000
5000
1000
500
500
500
500
500
500
500
500
0
0
4000
-4000
600
500
1500
100
8400
-4400
300
100
22500
200
24800
-6800
15300
19400
30000
300
66300
-33300
15500
19000
60000
400
96300
-43300
16000
18000
85000
1000
121500
-18500
16500
17000
120000
1000
156100
-3100
17000
16000
145000
1000
180850
22150
17500
15000
160000
1000
195500
57500
P: 555.123.4568 F: 555.123.4567
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Financial Projections
Financial Projection
300000
250000
Dollars
200000
150000
Cost
Revenue
100000
50000
0
2011
2012
2013
2014
2015
2016 2017
Year
2018
2019
2020
2021
2022
P: 555.123.4568 F: 555.123.4567
123 West Main Street, New York,
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Estimated Usage of Our Modular Incubation System
Estimated MIS Usage projection based on a
conservative 10% outreach to all neonatal deaths
from hypothermia. A more in-depth explanation is
in DS2: Basic summary of problem. As you can
see, the curve is sigmoidal and saturated at
roughly 72,000 neonates per year.
Estimated MIS Usage projection based on a conservative 10% outreach to all neonatal deaths from
hypothermia. A more in-depth explanation is in DS2: Basic summary of problem. As you can see, the
curve is sigmoidal and saturated at roughly 72,000 neonates per year.
P: 555.123.4568 F: 555.123.4567
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Future Plans
• Further testing of the ability of the space heater and warm water pump to
raise and maintain the temperature of a saline bag.
• Investigate and compare the functionality of other insulating materials.
• Begin fabrication of feedback mechanism
• Explore alarm system
• Finalize what products we will implement
in our Modular Incubation System
⁻ Method of Heating
⁻ Temperature Sensors
⁻ Insulating Material (if necessary)
P: 555.123.4568 F: 555.123.4567
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Acknowledgments
•
•
Instructors
– Dr. Elizabeth Hillman, Ph.D. , Biomedical Engineering Dept., Columbia University
– Dr. Aaron Kyle, Ph.D. , Biomedical Engineering Dept., Columbia University
– Mr. Keith Yeager
– Sarah De Leo (TA)
Advisers and Consultants
– Dr. Lance Kam, Ph.D., Biomedical Engineering Dept., Columbia University
– Dr. Margaret Nakakeeto-Kijjambu, MD, Mulago Hospital
– Dr. Richard Polin, MD, CUMC Pediatrics
– Dr. Rakesh Sahni, MD, CUMC Pediatrics
– Dr. Helen Towers, MD, CUMC Pediatrics
– Dr. Yvonne Vaucher, MD, UCSD
– Dr. David Vallancourt, Ph.D., Electrical Engineering Dept., Columbia University
IncuVive.weebly.com
P: 555.123.4568 F: 555.123.4567
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