Head-Of-Bed Elevation (HOBE) for Improving Positional Obstructive Sleep Apnea (POSA): An Experimental Study Maysoon Abu Assab, Joelle Sansour Rosary Sisters’ High School 13/5/2023 Abstract The study evaluates the efficacy of the head-of-bed elevation position (HOBE) in relieving upper airway obstruction in obstructive sleep apnea (OSA) patients. The protocol involved 45 patients. In the 30° up position, velum (V) and oropharynx lateral wall (O) collapses were reduced. 0° and 30° locations did not vary in tongue base and epiglottis obstruction. By adopting the HOBE posture with 30° head and trunk elevation, upper airway collapses and apnea/hypopnea events may be reduced. Introduction One of the most frequent sleep-disorder breathing (SDB) disorders is obstructive sleep apnea (OSA). It is characterized by a decrease (hypopnea) or full cessation (apnea) of upper airway airflow during the night. Head-of-bed elevation (HOBE) is a semi-sitting posture that facilitates blood oxygenation and allows for greater patient chest expansion and breathing. It is a valid decubitus alternative used to aid breathing in a variety of conditions. A 30 degree elevation of the head and trunk may be regarded as a fair compromise between the potential impact of upper airway stabilization and patient acceptability to sleep in the HOBE posture. Results Limited physiological and clinical studies have tested the impact of HOBE on OSA, mucous membrane collapsibility, and upper airway area. Anteroposterior and concentric velum collapse decreased significantly. Compared to moderate and severe OSA, mild individuals had less velum obstruction. Our prospective experiment evaluated the HOBE posture (30◦ elevation) in reducing upper airway obstruction and apnea/hypopnea events in OSA patients. During DISE assessment, total velum collapse decreased from 82.3% in the 0◦ supine position to 57.7% in the HOBE position , and total oropharynx lateral wall Table 1:DISE results according to 0◦ supine position and head-of-bed elevation (30◦ position). obstruction decreased from 60% to 33.3%. All individuals who demonstrated a shift in the HOBE position were overweight or obese, suggesting a greater BMI is linked to worse lung expansion due to the diaphragm's upward push and increased abdominal pressure. Conclusion Methods • All OSA patients referred to the Morgagni Pierantoni hospital in Forli, Italy, from January 2021 to January 2022. • All patients' medical histories were collected. • All study participants were evaluated: 1. drug-induced sleep endoscopy (DISE) with upper airway blockage and collapse examination at 0° and 30° head and trunk elevation. 2. Overnight PSG with head and trunk elevated from 0° to 30°. 3. Questions to analyze patients' HOBE input. Discussion Table 2; Differences in PSG outcomes between the 0◦ position and 30◦ up position. Adopting the HOBE position with a 30° elevation of the head and trunk (based on average SpO2, lower Spo2) can reduce upper airway collapses and improve apnea/hypopnea events. The manuscript has been read and approved by all authors; external funding was not used for this study. References Table 3: Feedback of patients to sleeping with head-of-bed elevation. Iannella G, Cammaroto G, Meccariello G, Cannavicci A, Gobbi R, Lechien JR, Calvo-Henríquez C, Bahgat A, Di Prinzio G, Cerritelli L, Maniaci A, Cocuzza S, Polimeni A, Magliulo G, Greco A, de Vincentiis M, Ralli M, Pace A, Polimeni R, Lo Re F, Morciano L, Moffa A, Casale M, Vicini C. Head-Of-Bed Elevation (HOBE) for Improving Positional Obstructive Sleep Apnea (POSA): An Experimental Study. Journal of Clinical Medicine. 2022; 11(19):5620.