SWAMI RAMANAND TEERTH MARATHWADA
UNIVERSITY, NANDED.
Under the guidance of
Dr. C.V. Panchal
M.Pharmacy,Assistant Professor
Pharmacognosy
Mr. Kunale Abhishek Anand. Mr. Mahegave Dnyaneshwar Madhavrao.
Miss. Langar Seema Sonerao. Mr. Mane Kedar Dipak.
DENGUE
INDEX
1) Introduction
2) Transmission cycle of dengue
3) Epidemology
4) Synonyms
5) Stages of dengue fever
6) Signs
7) Warning signs
8) Prevention
9) Management
10)Treatment
11)Conclusion
12)Survey at the site
13)Reference
INTRODUCTION
• Dengue is an infectious disease caused by a virus.
• The virus is transmitted to humans through the bites of
female mosquitoes (Aedes aegypti).
• This disease used to be called breakbone fever
because it sometimes causes severe
joint pain and muscle pain that feels like bones are
breaking.
DENGUE VIRUS:
• It is an RNA virus belonging to genus flavivirus and family
flaviviridae.
• Consists of 4 serotypes, DEN-1, DEN-2 , DEN-3 , DEN-4
• All serotypes can cause severe and fatal diseases.
• There is a short lived cross immunity between these species.
SYNONYMS OF DENGUE FEVER
1. Breakbone fever
2. Dandy fever
3. Dengue hemorrhagic fever
4. Dengue shock syndrome
5. Seven day fever
EPIDEMOLOGY
o In India first outbreak of dengue was recorded in 1812
o A double peak hemorrhagic fever epidemic occurred in India for the
first time in Kolkata between July 1963 &
March 1964
o In New Delhi, outbreaks of dengue fever reported in
1967, 1970, 1982, 1996, 2012 & 2015
o An estimated 5,00,000 cases of DHF require
hospitalization each year, of which a very large proportion
are children.
o A rapid rise in urban population is bringing greater
number of people.
TRANSMISSION CYCLE OF DENGUE:
Virus transmitted to human in mosquito saliva
Virus replicates in target organs.
Infects white blood cells & lymphatic tissues.
Virus released & circulates in blood.
Second mosquito ingests virus with blood.
Virus replicates in mosquito midgut & other organs,infects salivary glands.
Virus replicates in salivary glands.
STAGES OF DENGUE FEVER
1. Febrile stage
2. Critical stage
3. Recovery stage
FEBRILE STAGE ~
( FIRST4 DAYS)
✔High fever 40°C
✔Headache
✔Petechiae
✔Generalized arthralgia
✔Myalgia
✔Bleeding from mucous membrane
✔A rash occurs in 50-80%
CRITICAL STAGE~ (4 TH TO7 TH DAY)
✔Leukopenia
✔Thrombocytopenia
✔Increase capillary
permeability leading to
plasma leakage that lead
to metabolic acidosis
RECOVERY STAGE~ (7 TH TO1 0 TH DAY)
✔Stabilized hemodynamic
status
✔Increase urine output
✔Increase in fluid overload
can cause cerebral edema
SIGNANDSYMPTOMSOF DENGUEFEVERo
o
o
o
o
o
o
The incubation period is 4 to 7 days
Headache
Joint pain and muscle pain
Nausea
Vomiting
Pain behind the eyes
Swollen glands rash
WARNINGSIGNS
✔Abdominal pain or or tenderness
✔Vomiting
✔diarrhea
✔Signs of fluid accumulation
✔Ascites
✔Lethargy
✔Rapid increase in haematocrit with fall in
platelet
PREVENTION
Environmental:
•
•
•
•
Solid waste management
Reduced vector breeding sites
Empty water containers and cut grass
Personal protection
Chemical:
• Space spraying of insecticides
• Insecticide treatment of water containers
Personal protection
Use of mosquito nets, repellant creams, mosquito coils.
MANAGEMENT
o Oral rehydration therapy
o Intravenous fluids and
o Blood transfusion
TREATMENT
Conclusion
• Dengue is the most rapidly spreading mosquito- borne viral disease, with a
30-fold increase in global incidence over the past 50 years.
• Dengue is a global concern, with a steady increase in the number of
countries reporting the disease, currently close to 75% of the global
population exposed to dengue are in the Asia- Pacific region.
•
Mortality from dengue can be reduced to almost zero by implementing
timely, appropriate clinical management, which involves early clinical and
laboratory diagnosis, intravenous rehydration, staff.
• training and hospital reorganization.
1. Application
2. Google form:
3. Summery of survey:
4. Survey at site :
With Sarpanch
With Dr. Kamble(PHC Madansuri)
With patient and prescription:
Reference
⚫Park K. Park’s Textbook of Preventive And Social Medicine. 23 rd ed. Jabalpur (India): M/s Banarsidas Bhanot;2015.
P261-271.
Wallace B.R. Public health and Preventive Medicine, 15th
• Ed. New Delhi(India): McGraw Hill. P91-92.
WHO (2012), Global Strategy For Dengue Prevention and
•
Control, 2012-2020.
•
Govt. of India(2014), Operational Guidelines National
•
Programme for prevention and control of Dengue.
•
WHO: Dengue and severe dengue Fact sheet. Available from www.who.int/medicentre/factsheebris (17cm (accessed 05
December 2017)
•
Bhatt S, Gething PW, Brady OJ, Messina JP, Farlow AW, Moyes CL et.al. The global distribution and burden of dengue.
Nature:496:504-507
•
W.H.O. Dengue: guidelines for diagnosis, treatment, prevention and control. WHO/HTM/NTD/DEN/2009.1. World Health Organization;
2009.
•
GOI initiatives for Dengue and Chikungunya. Available from nvbdcp.gov.in/dengue-goi- activities.html (accessed 05 December 2017).