Lyceum of the Philippines University College of Nursing Drug Name Brand Name: Methergine Generic Name: Methylergometrine Dosage: 0.2 mg Route: Orally Frequency: 1 tab TID Classification and Mechanism of Actions Ergot Alkaloids Methylergometrine acts directly on the smooth muscle of the uterus and increases the tone, rate, and amplitude of rhythmic contractions through binding and the resultant antagonism of the dopamine D1 receptor. Thus, it induces a rapid and sustained tetanic uterotonic effect which shortens the third stage of labor and reduces blood loss. Indication Prevention and treatment of postpartum hemorrhage Contraindication Side Effects/Adverse Reaction CNS: dizziness, headache, hallucination, seizures, CVA (with I.V. use) Hypersensitivi ty to drug Hypertension Toxemia Pregnancy (except during the CV: hypertension, third stage of hypotension, transient chest labor) pain, palpitations, thrombophlebitis EENT: tinnitus, nasal congestion GI: nausea, vomiting, diarrhea GU: hematuria Musculoskeletal: leg cramps Respiratory: dyspnea Skin: diaphoresis, rash, allergic reactions Other: foul taste Nursing Responsibilities Watch out for uterine contractions and bleeding. Inform patient and family of reason for using drug, and provide reassurance. Tell patient drug may cause nausea, vomiting, dizziness, increased blood pressure, headache, ringing in ears, chest pain, or shortness of breath.. Monitoring Parameters CBC BP Pulse rate Drug Name Brand Name: Buscopan Generic Name: Hyoscine Butylbromide Dosage: 20-40 mg Route: IV Frequency: PRN Classification and Mechanism of Actions Antispasmodic Hyoscine is used to relieve smooth muscle spasms (cramps) in the stomach and intestines and in the bladder and urethra. Indication Postoperati ve nausea and vomiting Motion sickness Contraindication Hypersensitivity Side Effects/Adverse Reaction CNS: drowsiness, dizziness, confusion, restlessness, fatigue CV: tachycardia, palpitations, hypotension, transient heart rate changes EENT: blurred vision, mydriasis, photophobia, conjunctivitis GI: constipation, dry mouth GU: urinary hesitancy or retention Skin: decreased sweating, rash Nursing Responsibilities Caution patient to avoid alcohol because it may increase CNS depression. As appropriate, review all other significant adverse reactions and interactions, especially those related to the drugs, herbs, and behaviors mentioned above. Monitoring Parameters Assess vital signs and neurologic, cardiovascular , and respiratory status. Monitor patient for urinary hesitancy or retention Drug Name Brand Name: Feosol, Hemovit Generic Name: Ferrous Sulfate Dosage: 300 to 325 mg; 1 Tab Classification and Mechanism of Actions Replaces iron stores needed for red blood cell development as well as energy and O2 transport and use. Iron deficiency anemia, prophylaxis for iron deficiency in pregnancy, nutritional supplementation. Indication Contraindication Prevention and treatment of iron deficiency anemias Dietary supplement for iron Side Effects/Adverse Reaction GI: Nausea, Contraindicated constipation, with allergy to epigastric pain, any ingredient; black and red sulfite allergy tarry stools, Use cautiously vomiting, with normal diarrhea iron balance; peptic ulcer, INTEG: regional Temporarily enteritis, discolored tooth ulcerative enamel and colitis. eyes Nursing Responsibilities Route: Oral Frequency: OD for 1 month Inform the patient that taking this drug will cause their stools to turn dark green or black. Educate the patient that this medication should be taken between meals for best absorption. Encourage the patient to take this medication with orange juice. Tell the patient to avoid reclining position for 1530 minutes after taking to avoid esophageal corrosion. Monitoring Parameters Fluids & Electrolytes BP, RR, HR, PR Hct Hemoglobin Reticulocytes Bilirubin Drug Name Classification and Mechanism of Actions Brand Co-amoxiclav is Name: an antibiotic used Augmentin for bacterial infections. It contains Generic amoxicillin (an Name: Co- antibiotic from the Amoxiclav penicillin group of medicines) mixed with clavulanic Dosage: acid. The 625mg clavulanic acid stops bacteria from breaking Route: down amoxicillin, Orally allowing the antibiotic to work better. Frequency: 1 tab q12 Indication Contraindication Infections Hypersensitivity to penicillins. Crosssensitivity w/ other β-lactam antibiotics eg, cephalosporins. Previous history of jaundice/liver impairment associated w/ penicillins. Glandular fever or lymphatic lymphoma. Side Effects/Adverse Reaction Diarrhea Thrush Feeling of being sick Pain or tenderness in the upper stomach Nausea Pale stools Dark urine Vomiting Nursing Responsibilities Watch out for seizures Monitor signs of pseudomem branous colitis Monitor for signs of allergic reactions Monitoring Parameters Perform Culture and sensitivity test Monitor CBC with differential renal function test