Indications Contraindications HTN SVT / Atrial arrythmias Angina Prevent reinfarction s/p MI Migraine headaches Tremor, stage-fright ↓BP ↓HR 2⁰ or 3⁰ heart blocks Heart failure COPD / asthma Pregnancy Hypoglycemia (use caution) Drug Class Non-selective beta blockers “-LOL” Examples propranolol (non-selective) nebivolol (non-selective) Mechanism of Action Block the effects of norepinephrine at beta-1 and beta-2 adrenergic receptors of the sympathetic NS. Block “Flight-or-flight” Adverse Effects Bradycardia Hypotension / dizziness Heart Failure / pulm edema AV block Arrhythmias Bronchospasm Fatigue / ↓ exercise tolerance Impotence Hypoglycemia (esp with insulin) Depression Nursing Considerations Hold if HR <60 Hold if ↓BP Watch for worsening HR / crackles ECG monitoring (esp w/ IV) Watch for bronchospasm (asthma/COPD should have selective beta-1 blocker) Fall precaution Careful with diabetics – monitor glucose Do not abruptly D/C Interacts with NSAIDs (less effective)