Pathogensis of Diabetes
mellitus
• Diabetes mellitus is a metabolic disease due to absolute or relative
insulin deficiency characterised by hyperglycemia.
• Etiologic classificataion of DM :
Type 1 (IDDM): due to B-cell destruction with absolute deficiency of
circulating insulin.
Type 2(NIDDM): due to insulin resistance with relative insulin deficiency
MODY: maturity onset diabetes of young: due to defective glucokinase enzyme.
Gestational diabetes : DM prone state
In both of the common types of diabetes, environmental factors interact with genetic susceptibility to
determine which people develop the clinical syndrome, and the timing of its onset.