Manifestation on the Disease of Hair • Griscelli syndrome type 1 involves severe problems with brain function in addition to the distinctive skin and hair coloring. • Affected individuals typically have delayed development, intellectual disability, seizures, weak muscle tone (hypotonia), and eye and vision abnormalities. • REFERENCE: Griscelli Syndrome. Retrieved from https://medlineplus.gov/genetics/condition/griscellisyndrome/#:~:text=Griscelli%20syndrome%20type%201%20involves,and%20eye%20and%20vision%20abno rmalities.