Psychiatric Drug Classification Index Sheet Worksheet to be used as a tool for collection of drug classification data to be submitted for grading. The student will be assigned, by their clinical professor, one of the following specific psychiatric drug classifications: (Benzodiazepines, SSRI, SNRI, TCA, MAOI, Lithium, Mood Stabilizers, 1st Generation Antipsychotics, 2nd Generation Antipsychotics). The student will research the assigned psychiatric drug classification and complete the Psychiatric Drug Classification Index Sheet below. List the drug classification in the left column & fill in the related information in the columns provided. Drug Classification Safe Dose. Route, Onset, and Frequency Action and Therapeutic Response List the drug classification and names of generic drugs within the classification Onset: How long until they take effect? What is this drug classification used for? Why would a patient receive this medication? Lithium (Eskalith, Lithobid) – CNS Psychotherapeutic Agent, Mood stabilizer Peak : 0.53hrs Route/Safe dose/ Frequency PO 300 mg t.i.d. or q.i.d. or 15–20 mL (24–32 mEq) solution in 2–4 divided doses (max: 2.4 g/d) Mood stabilizer used to treat a patient who has mood disorders such as mania. Side Effects/Toxicity Common Side Effects and Rare, but Serious Side Effects Expected S.E – N/V/D, thirst, fine hand tremors, polyuria, weight gain, goiter. Early toxicity – GI upset, coarse tremors, hyperirritability of muscles, EEG changes, sedation, incoordination. Advanced toxicity – Ataxia, serious EEG changes, blurred vision, seizures, severe hypotension, pulmonary issues. Severe toxicity – Convulsions, oliguria, death Pre – and – Post Assessments (i.e., labs, relevant vital signs, nursing observations), physical assessments, teaching etc. (Nursing Implications and Important Patient Teaching) - assess patient’s mental alertness first - Lithium lab results and CBC count. - assess renal & thyroid function. - assess lithium levels periodically when patient is on medication. Note : Therapeutic levels : 0.8-1.4 Maintenance : 0.4-1.3 Toxicity : > 1.5+ Education: - Monitor fluid/Na+ intake, monitor fluid loss, regular weights, take with meals d/t GI upset, check with HCP before taking NSAIDS, must be tapered off to discontinue. - do not drive or engage in hazardous activities until response to drug is established. Instructor Feedback Valproate (Depokote) – CNS Agent, Anticonvulsant, GABA Inhibitor Carbamazepine (Tegretol) – CNS Agent, Anticonvulsant Peak: 1–4 hr Therapeutic Range: 50– 100 g/mL. Route/Safe dose/ Frequency PO/IV 15 mg/kg/d in divided doses when total daily dose >250 mg, increase at 1 wk intervals by 5–10 mg/kg/d until seizures are controlled or adverse effects develop (max: 60 mg/kg/d) Peak : 2-8 hrs Route/Safe dose/ Frequency PO 200 mg b.i.d., gradually increased to 800–1200 mg/d in 3–4 divided doses. Used in patients for management of seizures, mania, migraines. Used in patients with rapid cycling periods, severe paranoia, angry mania, seizures. Expected S.E – sedation, drowsiness, N/V, bleeding. Adverse S.E – Coma, death (if OD), liver failure, pancreatitis, bone marrow depression. Expected S.E – bone marrow suppression, liver inflammation, leukopenia Adverse S.E – Heart block. aplastic anemia, agranulocytosis, respiratory depression. - assess patient’s mental alertness first. Lab: - baseline platelet count/time, serum ammonia. Education: - refrain from alcohol. - Do not self-medicate with OTC meds. - do not drive or engage in hazardous activities until response to drug is established. - assess patient’s mental alertness first. Lab: - baseline & periodic CBC (platelets, electrolytes, iron, BUN, urinalysis) - monitor I/O, cardiac function - monitor neuro and mental cognition Education: - discontinue if S&S f toxicity (anorexia, fever, sore throat, fatigue, bleeding from areas) - refrain from alcohol. - Do not self-medicate with other meds/OTC meds. - do not drive or engage in hazardous activities until response to drug is established. - Do not stop abruptly. Lamotrigine (Lamictal) – CNS agent, Anticonvulsant Onset: 12 weeks, Peak 1-4 hrs Route/Safe dose/ Frequency PO Start with 25 mg q.d. for 2 wk, then 50 mg q.d. for 2 wk, then 100 mg/d for 1 wk, then 200 mg q.d. Used in patients with partial seizures, bipolar and mood disorders. Expected S.E – dizziness, ataxia, drowsiness, headache, nausea, blurred vision Adverse S.E – Steven Johnsons Sydrome, toxic epidermal necrolysis (rash). - Always assess patient’s mental alertness first. Lab: - monitor plasma levels of the drug. Education: - Do not self-medicate with other meds/OTC meds. - do not drive or engage in hazardous activities until response to drug is established.