Blood Clotting Hope Jin Blood Clotting or Coagulation a process of preventing a copious bleeding when a blood vessel is injured. How does the blood clotting work? 1. Blood vessels are damaged 2. platelets activate, chain reaction occurs 3. Fibrinogen reacts with with platelet and produce fibrin 4. Clot is made by fibrin and platelet Disease caused by blood clotting Deep Vein Thrombosis A clot forms in a major vein of the body, especially leg may restrict the return of the blood to the heart. Pulmonary Embolism Clot in a vein detach and travel through the heart to the lungs where it becomes wedged. How DVT can lead to PE