BI 23: HUMAN PHYSIOLOGY
Dr. Paul Delaney
Student_________________________
Date __________________________
CLINICAL CASE REPORT
Chapter 7 Running Problem: Graves’ Disease
Case History/Background:
Questions:
1) a) To which of the three classes of hormones do thyroid hormones belong?
Facts:
Integration and Analysis:
1) b) If a person’s diet is low in iodine, predict what happens to thyroxine production.
Facts:
Integration and Analysis:
2) a) In a normal person, when thyroid hormone levels in the blood increase, will
negative feedback increase or decrease the secretion of TSH?
Facts:
Integration and Analysis:
BI-23 Human Physiology Clinical Case
2) b) In a person with a hyperactive gland that is producing too much thyroid hormone,
would you expect the level of TSH to be higher or lower than in a normal person?
Facts:
Integration and Analysis:
3) Why is radioactive iodine (rather than some other radioactive element, such as
cobalt) used to destroy thyroid tissue?
Facts:
Integration and Analysis:
4) If levels of TSH are low and thyroxine levels are high, is Graves’ disease a primary
disorder or a secondary disorder (one that arises as a result of a problem with the
anterior pituitary or the hypothalamus)?
Facts:
Integration and Analysis:
5) Antibodies are proteins that bind to the TSH receptor. From that information, what
can you conclude about the cellular location of the TSH receptor?
Facts:
Integration and Analysis:
6) In Graves’ disease, why doesn’t negative feedback shut off thyroid hormone
production before it becomes excessive?
Facts:
Integration and Analysis:
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