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None of the data presented in this manuscript have been plagiarized, fabricated, manipulated or falsified. All original data are distinguished clearly from previously published data. All original sources upon which information in the manuscript is based, and all theories and data from previously published sources, have been properly identified and cited. The sources of all previously published figures, tables, data, photographs, etc. in the manuscript have been cited, and all necessary permissions to reproduce them in any medium have been provided. Permission has been obtained from all persons who provided unpublished data verbally or in writing, and all verbal and written communications are clearly identified as such and attributed to their author(s). Statement of partial or total overlap (Please check only those boxes that apply) Parts of this manuscript have been published previously (Please provide relevant details below in the Comments box, along with the overlapping text.) 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All authors of this manuscript have avoided errors in the experimental or theoretical design, presentation and interpretation of the results. If any such errors are detected in the manuscript before or after publication, the authors will immediately alert the Editors. The results of this study have been interpreted objectively. Any results that contradict the authors’ point of view have been discussed in the manuscript. Acknowledgments (Both boxes must be checked.) All sources of funding provided for this study are acknowledged, with a concise mention of the funding organization and identification code. All persons who contributed to the manuscript but who are not authors and who are not responsible for preparation of the manuscript are mentioned in the Acknowledgments. Conflicts of interest (Please check only if applicable.) 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Distribution of the article in this manner ensures that authors are in compliance with current Spanish legislation (Ley 14/2011, de 1 de junio, de la Ciencia, la Tecnología y la Innovación, artículo 37.3) regarding the requirement to provide open access to research results obtained with funding from public research organizations. 3 JOURNAL Title of the journal TITLE OF MANUSCRIPT Title of the manuscript (max. 300 characters) AUTHORS SURNAME(S) NAME SIGNATURE DATE 4 COMMENTS Comments (max. 4000 characters) 5