MRI Core Steering Committee
April 2011
Matt Bernstein PhD – editor in chief
Magnetic Resonance in Medicine, 2011
ADNI--1 Carry Forward Policy: 51 sites
ADNI



Same 1.5T
1 5T system if available for ADNIADNI-2 (46/51)
If site changes to comparable 1.5T system then qualify
new 1.5T
T system (0/51)
/
If change 1.5T vendor or major
j HW change  move
site to 3T protocol (5/51)  ADNI
ADNI--1 treated as new
patients from MRI p
p
perspective)
p
)
T1 pre processing


OLD 1.5T: “Clippy” – Mayo + Dale, Gradwarp, bias
correction (N3
(N3), B
B11 correction + phantom scaling
NEW (3
(3T + new 1.5T in ADNI -1): “Grinder” Mayo –
two operations:
p
3D gradwarp correction for GE and Siemens ((33D GW is
product default on Phillips)
p
p)
 N3m bias correction for all scans




B1 correction not available on GE or Siemens when
ADNI 1 began, but is product on all new scanners
no scaling
li correction
ti in
i ADNI 2
Select ““--chosen” for ADNI/GO/
ADNI/GO/22
ADNI--2 MRI 3T Protocol
ADNI
3D T1 volume unun-accelerated (MPRAGE on Siemens
p , IR SPGR on GE)) – for volumetric analyses
y
and Phillips,
 3D T1 volume 2X accelerated - for volumetric analyses
 FLAIR – for cerebro vasc
vascular
lar disease grading
 long TE 2D gradient echo –micro hemorrhage grading
====================================
 Experimental:
E pe e ta : SSiemens
e e s (ASL
( S perfusion),
pe us o ), GE (DTI),
(DT ),
Phillips (resting state EPIEPI-BOLD)
====================================
 Phantom (once per day if > 1 ADNI patient)

Protocol Changes

I iti l QC andd External
Initial
E t
l Advisors
Ad i
External Advisors



ASL - John Detre and Xavier Golay
DTI - Susumu Mori and Christophe Lenglet
resting state - Randy Buckner, Gary Glover, Steve
Smith, Vince Calhoun, Mike Grecius
Phillips Changes





EPI-BOLD: increased SI coverage to 159mm - now 7
EPIminutes
i
- distributed
di ib d iin SSeptember
b 2010
2010.
External advisors: Add a phase map
No product – but a phase map acquisition was
developed
p that could be executed with p
product
sequences -with Yansong Zhao PhD (Philips physics
staff at BU,, courtesyy of Ron Killiany*
Killiany*)
y )
this change will be distributed to sites soon
Philips:
Phili 12/55 ADNIADNI-2 sites
it
Phase Map
GE Changes
g






increase SI coverage of the DTI sequence to 159mm
Increased time to 77-11 minutes
external advisors advised us to add a p
phase map
p to
DTI
can not be done using product sequences
correct for distortions in DTI using alignment to
undistorted
di t rt d anatomical
t mi l scans
GE: 15/55 ADNIADNI-2 sites
Siemens Changes




ASL: some exams do not fully cover the base of the
b i and
brain
d cerebellum,
b ll
b
but no modification
difi i at the
h advice
d i
of Siemens corporate engineering, increasing SI
coverage would
ld interfere
i
f with
i h spin
i labelling
l b lli
Initial quality reviews revealed high variability of the
perfusion signal within and across subjects consequently adjusted several timing parameters.
added product phase map: distributed to Siemens sites
in JJanuaryy 2011
Siemens: 28/55 ADNI
ADNI--2 sites
Addition of 4th Special Sequence to Siemens





4th specialized sequence for hippocampal subfield
measures – to be
b added
dd d to Siemens
Si
systems
10 Siemens sites not yet purchased ASL site licences,
initial plan was to add ASL as the site licenses came on
line. However, considerably slower than anticipated
In interim, Susanne Mueller, San Francisco VA, received
fundingg to perform
p
hippocampal
pp
p sub field analyses
y in
ADNI 2
requires a specialized high resolution sequence
plan to distribute within the next month
3T high resolution hippocampus sequence
Analysis: Paul Thompson


Tensor Based Morphometry of 3D T1 weighted
volumetric
l
i MRI – cross sectional
i l andd llongitudinal
i di l
volumes and rates of change of specific structures
(
(e.g.,
hippocampus),
hi
) andd volumetric
l
i changes
h
in
i lobar
l b
and statistically defined ROIs.
DTI – HARDI method that uses deconvolution to
correctly estimate fiber integrity (“corrected” FA) in
places where fibers mix, cross, or are partial volumed
with other tissues (e.g. GM or CSF)
Nick Fox


Boundary Shift Integral – cross sectional and rates of
change
h
off whole
h l b
brain
i and
d ventricular
i l volume
l
hippocampal volume of 3D T1 - cross sectional and
rates of change
Mayo



STAND score of 3D T1
micro hemorrhages - grading of number and location
and change over serial scans of MCH and superficial
siderosis
Restingg State EPIEPI-BOLD
Resting State Connectivity Matrix
Charlie DeCarli




Four tissue segmentation and vascular disease from
combined
bi d MP
MP--RAGE and
d FLAIR – grading
di off
infarctions and white matter hyper intensity volume on
b li and
baseline
d serial
i l MRI studies.
di
will post segmented images on the LONI website
Numeric summary measures (total gray, white, CSF and
WMH volumes).
)
DTI – atlas based approach, evaluating impact of
vascular disease on white matter fiber integrity
Norbert Schuff



FreeSurfer of 3D T1 –cross sectional and longitudinal
change
h
measures off cortical
i l thickness
hi k
and
d volumes
l
ffor
all ROIs in the Freesurfer atlas, approximately 97
i l di hi
including
hippocampus and
d entorhinal
hi l cortex.
ASL – Perfusion maps for each subject will be provided
as will perfusion measures by ROI.
The ROIs will overlap
p with those reported
p
byy the FGDFGDPET group.
ADNI GO/ADNI 2 Documentation
Overview – (pdf Alzheimer's Disease and Dementia (2010)
3T ADNIGO/2 MRI Protocols – (link to protocols)
Individual Sequence Documentation (links)
3D T1
FLAIR
GRE
DTI
Protocol Changes
Documentation
Image Processing
Documentation
QC Documentation
Images/Maps/Masks Sent to
LONI
Numerical Data sent to LONI
ADNIGO/2
GO/ 1.5T
5 Co
Continuing
u g Subjec
Subjects
s Protocols/Documentation
ADNI 1 Database
(Overview pdf JMRI 2008, Protocols, Documentation, Board)
ASL
Resting State
EPI-BOLD