» Supports Healthy Energy Production and Metabolism*
» Supports Immune Function*
» Supports Intestinal Health*
» Supports Healthy Intestinal Cytokine Balance*
» Supports Healthy Body Composition*
» Supports Detoxification and Antioxidant Systems*
Available in Vanilla Latte
i5 Energize ™ is an innovative and healthy way to add protein, micronutrients, immunoglobulins, and fiber to your daily routine. This nutritious and delicious shake provides antioxidant, detoxification, and energy support. It can be part of a healthy and energizing breakfast, a great pre-workout shake, or a quick pick-me-up in the afternoon. i5
Energize is a nutrient-rich alternative to common energy drinks.*
VegaPro ™ XYMOGEN’s proprietary blend of pea protein isolate, rice protein concentrate, taurine, glycine, and L-glutamine provides 18 g of plant-based protein per serving of i5 Energize. VegaPro is easily digested, is free of lactose and gluten, and achieves an amino acid score of 100%.
[1,2] This amino acid profile supports protein metabolism and lean body mass. Aminogen ® enhances protein digestibility and absorption.*
Coffee Fruit Extract and Green Coffee Bean Extract Blend i5
Energize contains a propriety blend of KonaRed ® coffee fruit extract, green coffee bean extract, and caffeine anhydrous. Hawaiian KonaRed coffee fruit extract is a natural source of chlorogenic acids and their derivatives quinic acid and ferulic acid.
[3] Chlorogenic acids from green coffee bean extract are readily metabolized by humans and have been researched specifically for their positive effects on cytokine balance and antioxidant support.
[4,5] Animal and human studies suggest that these chlorogenic acids can be used safely and help maintain vasoreactivity and blood pressure already within the normal range.* [6-8]
ActivNutrients ™ without Copper & Iron The USDA Dietary
Guidelines suggest that dietary supplements can help fulfill our micronutrient needs.
[9] The balanced array of vitamins, minerals, and cofactors in i5 Energize provides a micronutrient foundation that helps support healthy energy production and metabolism.
[10] ActivNutrients without Copper & Iron delivers highly bioavailable micronutrients, such as Albion ® TRAACS ® minerals (the real amino acid chelate system), natural-source vitamin E as mixed tocopherols, and activated B vitamins, including 5-methyltetrahydrofolate as Quatrefolic ® .* [11] i5 Energize ™ is an all-natural, nutrient-dense shake mix designed to support healthy energy production, gastrointestinal integrity, and the body’s natural ability to detoxify. It is a wholesome alternative for individuals seeking to maintain robust energy levels, enhance their workout, or simply maintain overall health and wellness. This unique, fructose-free formula contains the same micronutrient profile (different dosages) found in XYMOGEN’s ActivNutrients ™ without Copper & Iron, along with supplemental methylcobalamin (activated vitamin B12) and an energizing proprietary blend of coffee fruit extract and green coffee bean extract. i5 Energize features VegaPro protein) as well as IgG 2000 DF ™
™ (a non-GMO, pea-based
, OncoPLEX ™ serving.*
(glucoraphanin), and the prebiotic arabinogalactan. i5 Energize provides 80 mg of caffeine per
IgG 2000 DF ™ A breakthrough in immunoglobulin supplementation,
IgG 2000 DF is a purified, patented, serum-derived bovine immunoglobulin (SBI) concentrate that provides IgG (at least 45%),
IgA, IgM, IgE, IgD, transferrin, and growth factors. Oral immunoglobulin supplementation has been widely studied, and research suggests that the practice safely and effectively supports immune function in a variety of circumstances.
[12-14] An eight-week pilot study suggested that 2.5 g of oral SBIs (which contain the same actives as IgG 2000
DF) two times per day promoted lymphocyte repopulation of gutassociated lymphoid tissue as well as improvement in proximal small bowel function.* [15]
Research in animals and human cell lines suggests that the active ingredients in IgG 2000 DF support intestinal cytokine balance, especially when the IgG fraction is concentrated and standardized.
[16-19] Oral immunoglobulins have been used in sports nutrition to support lean body mass, [20] physical exercise, and recovery following high-intensity training.
[21] Though many studies utilize bovine colostrum at high doses, the source of immunoglobulin in i5 Energize is more concentrated; it is at least 45% IgG and contains more cystine
(precursor to cysteine and glutathione) than colostrum.*
OncoPLEX ™ (glucoraphanin) This patented plant-based ingredient, also known as sulforaphane glucosinolate, is extracted from one of its most concentrated cruciferous sources—broccoli seeds.
[22] An abundance of research demonstrates that when glucoraphanin is broken down to its active form, sulforaphane, it safely and effectively upregulates the body’s natural phase II detoxification enzymes.
[23-25]
This activity in turn supports antioxidant activity and helps protect cells, cell membranes, and tissues from free-radical damage.*
Arabinogalactan Sourced from the larch tree, arabinogalactan is considered an excellent source of fiber, a prebiotic, and a precursor to short-chain fatty acids, all elements that help support gastrointestinal health.* [26,27]
E X C L U S I V E
•
P AT E N T E D
*These statements have not been evaluated by the Food and Drug Administration.
This product is not intended to diagnose, treat, cure, or prevent any disease.
XYMOGEN ® Exclusive Professional Formulas
800-647-6100 | www.xymogen.com

i5 Energize ™ Supplement Facts
Serving Size: 2 scoops (44 g)
Servings Per Container: 14
Calories
Calories from Fat
Total Fat
Saturated Fat
Total Carbohydrate
Dietary Fiber
Sugars
Protein
Vitamin A (75% as natural beta-carotene and 25% as retinyl palmitate)
Vitamin C (as sodium ascorbate, potassium ascorbate, zinc ascorbate, and calcium ascorbate)
Vitamin D3 (as cholecalciferol)
Vitamin E (as d-alpha tocopheryl succinate and mixed tocopherols)
Thiamin (as thiamine mononitrate)
Riboflavin (as riboflavin 5’-phosphate sodium)
Niacin (as niacinamide and nicotinic acid)
Vitamin B6 (as pyridoxal 5’-phosphate)
Folate (50 mcg as (6S)-5-methyltetrahydrofolic acid, glucosamine salt † and 50 mcg as folic acid)
Vitamin B12 (as methylcobalamin)
Biotin
Pantothenic Acid (as d-calcium pantothenate)
Calcium (as DimaCal ® Dicalcium Malate and ingredients with naturally occurring calcium)
Iron (naturally occurring)
Iodine (as potassium iodide)
Magnesium (as DiMagnesium Malate)
Zinc (as TRAACS ® Zinc Bisglycinate Chelate)
Selenium (as Selenium Glycinate Complex)
Manganese (as TRAACS ® Manganese Bisglycinate Chelate)
Chromium (as TRAACS ® Chromium Nicotinate Glycinate Chelate)
Molybdenum (as TRAACS ® Molybdenum Glycinate Chelate)
Sodium (naturally occurring)
Potassium (from Potassium Glycinate Complex and ingredients with naturally occurring potassium)
IgG 2000 DF ™ (bovine serum-derived globulin protein concentrate)
Proprietary Energizing Blend
Coffee Fruit Extract and Green Coffee Bean Extract Blend
( Coffea arabica L.
)(fruit and bean)(30% chlorogenic acids) and caffeine anhydrous, yielding a total of 80 mg of caffeine
Arabinogalactan (from Larix laricina )(bark)
Aminogen ®
Glucoraphanin (from broccoli extract)( Brassica oleracea italica )
(seed)(SGS ™ )
Choline (as choline dihydrogen citrate)
Vanadium (as TRAACS ® Vanadium Nicotinate Glycinate Chelate)
Inositol
PABA ( para -aminobenzoic acid)
** Daily Value not estabilished.
† Percent Daily Values are based on a 2,000 calorie diet.
Amount Per Serving % Daily Value †
160
25
3 g
2.5 g
18 g
5 g
4 g
18 g
1875 IU
62.5 mg
50 IU
50 IU
5 mg
5 mg
16 mg
10 mg
100 mcg
2500 mcg
250 mcg
50 mg
55 mg
2.7 mg
25 mcg
25 mg
3.25 mg
25 mcg
0.125 mg
125 mcg
12.5 mcg
320 mg
320 mg
2.5 g
570 mg
500 mg
300 mg
30 mg
9 mg
187.5 mcg
9 mg
3.25 mg
5%
13%
6%
20%
36%
37.50%
104%
15%
17%
6%
22%
36%
6%
104%
17%
13%
9%
13%
167%
333%
294%
80%
500%
25%
41667%
83%
500%
6%
**
**
Other Ingredients: VegaPro ™ (XYMOGEN’s proprietary blend of pea protein isolate, taurine, rice protein concentrate, L-glutamine, and glycine), natural flavors (no MSG), inulin (from chicory), organic dried cane syrup, sunflower oil, tripotassium citrate, medium-chain triglycerides, cellulose gum, xanthan gum, and stevia leaf extract.
**
**
**
**
**
**
**
DIRECTIONS: Blend, shake, or briskly stir two level scoops (44 g) into 8-10 oz chilled water and consume one to two times daily, or as directed by your healthcare practitioner. Adjust amount of water to desired sweetness and thickness.
Consult your healthcare practitioner prior to use, especially during pregnancy or lactation. Caffeine should not be combined with synephrine or ephedrine. Use cautiously in individuals who have a history of abnormal heart rhythm. Do not use if tamper seal is damaged.
DOES NOT CONTAIN: Wheat, gluten, yeast, soy, dairy products, fish, shellfish, peanuts, tree nuts, egg, artificial colors, or artificial sweeteners.
STORAGE: Keep tightly closed in a cool, dry place out of reach of children.
AMINOGEN ® is a registered trademark of Triarco Industries.
AMINOGEN ® is protected under U.S. patent 5,387,422.
Produced under US patents 5,725,895; 5,968,505;
5,968,567; 6,177,122 and 6,242,018 licensed from of Brassica Protection Products LLC.
DimaCal, TRAACS, and the Albion Medallion design are registered trademarks of Albion Laboratories, Inc. Malates covered by U.S. Patent 6,706,904 and patents pending
© XYMOGEN
1. Fredrikson M, Biot P, Alminger ML, et al. Production process for high-quality pea-protein isolate with low content of oligosaccharides and phytate. J Agric Food Chem . 2001
Mar;49(3):1208-12. [PMID: 11312837]
2. Gausserès N, Mahé S, Benamouzig R, et al. [15N]-labeled pea flour protein nitrogen exhibits good ileal digestibility and postprandial retention in humans. J Nutr . 1997
Jun;127(6):1160-65. [PMID: 9187631]
3. KonaRed: Science. http://www.konared.com/science-most-powerful-antioxidant-fruits/.
Accessed April 25, 2013.
4. American Institute for Cancer Research. Foods That Fight Cancer: Coffee. http://www.aicr.
org/foods-that-fight-cancer/coffee.html. Accessed April 26, 2013.
5. Farah A, Monteiro M, Donangelo CM, et al. Chlorogenic acids from green coffee extract are highly bioavailable in humans. J Nutr . 2008 Dec;138(12):2309-15. [PMID: 19022950]
6. Watanabe T, Arai Y, Mitsui Y, et al. The blood pressure-lowering effect and safety of chlorogenic acid from green coffee bean extract in essential hypertension. Clin Exp
Hypertens . 2006 Jul;28(5):439-49. [PMID: 16820341]
7. Ochiai R, Jokura H, Suzuki A, et al. Green coffee bean extract improves human vasoreactivity. Hypertens Res . 2004 Oct;27(10):731-37. [PMID: 15785008]
8. Natural Standard Database. Green Coffee. http://www.naturalstandard.com/databases/ herbssupplements/greencoffee.asp?#undefined. Accessed June 3, 2013.
9. U.S. Department of Agriculture and U.S. Department of Health and Human Services.
Dietary Guidelines for Americans, 2010. 7th ed. Washington, DC: U.S. Government Printing
Office; December 2010:33-42. http://www.health.gov/dietaryguidelines/dga2010/
DietaryGuidelines2010.pdf. Accessed April 2, 2013.
10. Ames BN. A role for supplements in optimizing health: the metabolic tune-up. Arch
Biochem Biophys . 2004 Mar 1;423(1):227-34. [PMID: 14989256]
11. Quatrefolic. http://www.quatrefolic.com/4thGeneration.html. Accessed April 27, 2013.
12. Weiner C, Pan Q, Hurtig M, et al. Passive immunity against human pathogens using bovine antibodies. Clin Exp Immunol . 1999 May;116(2):193-205. http://onlinelibrary.wiley.com/ doi/10.1046/j.1365-2249.1999.00880.x/pdf. Accessed April 26, 2013.
13. Bogstedt AK, Johansen K, Hatta H, et al. Passive immunity against diarrhoea. Acta
Paediatr . 1996 Feb;85(2):125-28. Review. [PMID: 8640033]
14. Warny M, Fatimi A, Bostwick EF, et al. Bovine immunoglobulin concentrate clostridium difficile retains C difficile toxin neutralising activity after passage through the human stomach and small intestine. Gut . 1999 Feb;44(2):212-17. [PMID: 9895380]
15. Asmuth DM, Ma Z M, Albanese A, et al. Oral serum-derived bovine immunoglobulin (SBI) administration leads to duodenal gastrointestinal-associated lymphoid tissue (GALT)
CD4+ T-lymphocyte increases and improved small intestinal absorption function in an
8-week pilot study in patient. In: 19th International AIDS Conference; July 22-27, 2012;
Washington, DC. Abstract TUAA0304. http://www.iasociety.org/Abstracts/A200745325.
aspx. Accessed April 25, 2013.
16. Pérez-Bosque A, Miró L, Polo J, et al. Dietary plasma protein supplements prevent the release of mucosal proinflammatory mediators in intestinal inflammation in rats. J Nutr .
2010 Jan;140(1):25-30. [PMID: 19923397]
17. Pérez-Bosque A, Amat C, Polo J, et al. Spray-dried animal plasma prevents the effects of
Staphylococcus aureus enterotoxin B on intestinal barrier function in weaned rats. J Nutr .
2006 Nov;136(11):2838-43. [PMID: 17056810]
18. Wolf HM, Eibl MM. The anti-inflammatory effect of an oral immunoglobulin (IgA-IgG) preparation and its possible relevance for the prevention of necrotizing enterocolitis. Acta
Paediatr Suppl . 1994;396:37-40. Review. [PMID: 8086680]
19. Pierce JL, Cromwell GL, Lindemann MD, et al. Effects of spray-dried animal plasma and immunoglobulins on performance of early weaned pigs. J Anim Sci . 2005
Dec;83(12):2876-85. [PMID: 16282627]
20. Antonio J, Sanders MS, Van Gammeren D. The effects of bovine colostrum supplementation on body composition and exercise performance in active men and women. Nutrition . 2001
Mar;17(3):243-47. [PMID: 11312068]
21. Shing CM, Hunter DC, Stevenson LM. Bovine colostrum supplementation and exercise performance: potential mechanisms. Sports Med . 2009;39(12):1033-54. Review. [PMID:
19902984]
22. The science behind SGS. http://www.sgs-broccoli.com/sgs-advantage/science-behindsgs-2. Accessed June 4, 2013.
23. Boddupalli S, Mein JR, Lakkanna S, et al. Induction of phase 2 antioxidant enzymes by broccoli sulforaphane: perspectives in maintaining the antioxidant activity of vitamins A, C, and E. Front Genet . 2012;3:7. [PMID: 22303412]
24. Sulforaphane glucosinolate. Monograph. Altern Med Rev . 2010 Dec;15(4):352-60. Review.
[PMID: 21194251]
25. Fahey JW, Talalay P. Antioxidant functions of sulforaphane: a potent inducer of Phase II detoxification enzymes. Food Chem Toxicol . 1999 Sep-Oct;37(9-10):973-79. [PMID:
10541453]
26. Larch arabinogalactan. Altern Med Rev . 2000 Oct;5(5):463-66. [PMID: 11056416]
27. Kelly GS. Larch arabinogalactan: clinical relevance of a novel immune-enhancing polysaccharide. Altern Med Rev . 1999 Apr;4(2):96-103. Review. [PMID: 10231609]
Additional references available upon request
† Quatrefolic ® is a registered trademark of Gnosis
S.p.A. Produced under US Patent 7,947,662.
E X C L U S I V E
•
P AT E N T E D
All XYMOGEN ® Formulas Meet or Exceed cGMP Quality Standards.
*These statements have not been evaluated by the Food and Drug Administration.
This product is not intended to diagnose, treat, cure, or prevent any disease.
(RV) DRS-279
Rev. 10/14/13