(Approximate) schedule for the course
Molecular Mechanisms in Cancer 2015
Day 1, November 16th 2015, Stratenum Room 2.106
9.15
9.30
10.30
12.00
13.00
14.30
15.00
Coffee
Course Introduction
Team assignment
Lunch
Lecture ‘Hallmarks of Cancer’
Coffee
Divide & Conquer (educational game)
Literature to study upforehand (read through):
Hallmarks of cancer: the next generation.
Hanahan D, Weinberg RA. Cell. 2011 Mar 4;144(5):646-74. doi:
10.1016/j.cell.2011.02.013
Day 2, November 17th 2015, Stratenum Room 2.106
9.15 Coffee
9.30 Introduction of today’s speaker (Marcel van Vugt) & topic
10.00 Team assignment: prepare 10 minute presentation on one aspect of today’s topic:
o Signaling cascade
o Molecular Mechanism of regulation (structural level)
o Common assays for detection/activity/regulation
o Drug target and Mechanism of action
o Clinical relevance in cancer
12:30 Presentations
13:30 Prepare questions for the speaker
15:00 Seminar Marcel van Vugt, Vondelzaal, STR 3.108
16:00 Discussion with the speaker
17:00 End
Literature to be studied upforehand:
The DNA damage response: making it safe to play with knives.
Ciccia A, Elledge SJ.
Mol Cell. 2010 Oct 22;40(2):179-204. doi: 10.1016/j.molcel.2010.09.019. Review. PMID:
20965415
APC/C(Cdh1) controls CtIP stability during the cell cycle and in response to DNA damage.
Lafranchi L, de Boer HR, de Vries EG, Ong SE, Sartori AA, van Vugt MA. EMBO J. 2014
Dec 1;33(23):2860-79. doi: 10.15252/embj.201489017. Epub 2014 Oct 27.
PMID: 25349192
Rif1 Is Required for Resolution of Ultrafine DNA Bridges in Anaphase to Ensure Genomic
Stability.
Hengeveld RC, de Boer HR, Schoonen PM, de Vries EG, Lens SM, van Vugt MA.
Dev Cell. 2015 Aug 24;34(4):466-474. doi: 10.1016/j.devcel.2015.06.014. Epub 2015 Aug
6. PMID: 26256213
Day 3, November 18th 2015, Stratenum Room 2.106
9.15 Coffee
9.30 Introduction of today’s speaker (Frauke Melchior) & topic
10.00 Team assignment: each team prepares a 10 min presentation on one aspect of
today’s topic:
o Signaling cascade
o Molecular Mechanism of regulation (structural level)
o Common assays for detection/activity/regulation
o Drug target and Mechanism of action
o Clinical relevance in cancer
12:30 Presentations
13:30 Prepare questions for the speaker
15:00 Seminar Frauke Melchior, Vondelzaal, STR 3.108
16:00 Discussion with the speaker
17:00 End
Literature to be studied upforehand:
The SUMO pathway: emerging mechanisms that shape specificity, conjugation and
recognition. Gareau JR, Lima CD. Nat Rev Mol Cell Biol. 2010 Dec;11(12):861-71. doi:
10.1038/nrm3011. Review. PMID: 21102611
Regulation of SUMOylation by reversible oxidation of SUMO conjugating enzymes. Bossis
G, Melchior F. Mol Cell. 2006 Feb 3;21(3):349-57.PMID: 16455490
Day 4&5, November 19th, 20th 2015 CGC.nl meeting
Koninklijk Instituut voor de Tropen, Mauritskade 63, Amsterdam (getting there is your own
responsibility!, free lunch!). The Program can be found here:
http://www.cancergenomics.nl/UserFiles/File/program%20annual%20CGCnl%20meeting%
202015.pdf
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
For each day pick one presented research project you would choose to follow up on
for your post-doc/PhD project/funding. Write a half page to briefly summarize the
talk and to present your follow-up project.
For each day pick one presented research project you would definitely not choose
to follow up on for your post-doc/PhD project/funding. Write a half page to briefly
summarize the talk and to describe how you would change that project to give it a
better perspective in your opinion.
Each day will be followed by drinks and discussion with the students, from 17:00
until 18:30. Venue will be in the Tropen Hotel, Suriname zaal, located next to the
Tropenmuseum.