Reproductive Fitness and Prenatal Nutrition By Jennifer Turley and Joan Thompson © 2016 Cengage Introduction • PRE-CONCEPTUAL NUTRITION • Nutrition and Fertility • Building the Blue Ribbon Baby • Energy and Nutrient Needs • PRENATAL NUTRITION • Monitoring Good Nutrition during Pregnancy • Energy and Nutrient Needs • Diet and Health Issues in Pregnancy • MyPlate for Pregnant Women • Prenatal Fitness and Lifestyle Management Pre-Conceptual Nutrition • Nutrition affects fertility, conception, implantation and embryonic development • Normal healthy body weight • An antioxidant-rich nutritionally adequate diet is needed; especially important is sufficient folic acid and iron – Genetic mutations, MTRR or MTHFR, prevent the conversion of folate to folic acid Nutrition and Fertility Female & Male Fertility Females: Low body fat inhibits ovulation, excess body fat inhibits conception. A diet low in TFAs, and SFAs, with higher MUFAs, vegetable proteins, fiber, low GI carbohydrate sources and adequate vitamins and minerals is a fertility diet. Males: An organic diet free of pesticides supports fertility. Nutrition and Fertility Celiac Disease and Infertility • Celiac disease is an autoimmune disease causing intestinal damage • Dietary gluten from wheat, barley, and rye trigger the autoimmunity and malnutrition • Breastfeeding, delaying introduction of gluten and amount of gluten exposure in infancy may reduce disease risk • Female reproduction: Delayed menarche, amenorrhea, early menopause, infertility, hypogonadism, recurrent abortions, and lowbirth-weight or preterm deliveries • Male reproduction: Impotence Nutrition and Fertility Polycystic Ovarian Syndrome • Endocrine disorder affecting 5-10% of women • Caused by insulin resistance • 60% have weight management issues, increased risk of diabetes and gender cancers • Irregular or no menstrual periods or irregular ovulation, with or without monthly bleeding. • Painful un-ruptured follicles on the periphery of the ovaries • Acne and excess hair growth on the face and body with thinning scalp hair Building the Blue Ribbon Baby • Healthy baby born at term from an uncomplicated pregnancy • 7 lb, 8 oz, 20 “ long The Menstrual Cycle Follicular Phase: Days 1-14, ovum development, estrogen domination, stable emotions, increased synthesis of serotonin and endorphin (feel good neurochemicals) Luteal Phase: Increasing progesterone, diminishing estrogen, serotonin and endorphin; inflammation, craving sweet-fat treats. A balanced diet helps transition through the cycle Basics of Conception and Genetics • 48 hour conception window , just prior to or at ovulation • Building the baby requires meiosis and mitosis. • Typical body (somatic) cells reproduce or divide by mitosis • Gametes: egg and sperm with ½ the chromosomes, 23 each • Zygote: produced from 2 fused gametes, has 46 chromosomes; 23 sets of 2, 1 set determines gender • Cellular division (mitosis) and cellular differentiation continue to occur through embryonic and fetal development Energy and Nutrient Needs, Part 1 • Energy and nutrient needs pre-conceptually are the same as a non-pregnant woman by life stage group • Nutrient stores to sponsor a pregnancy and to prevent maternal nutrient store depletion • Calories: Gender and age specific EER formula • Carbohydrate: 130 grams/day minimum; 45-65% of Calories; ≤25% Calories from sugars; 1.4 grams/100 Calories for fiber • Protein: 0.8 gram/Kg; 10-35% of Calories • Fat: Adequate EFAs, 20-35% of Calories Vitamins, Minerals, Water • • • • Adult female values Need adequate iron stores Water DRI of 2.7 liters per day Need adequate folic acid to prevent neural tube defects; supplements and/or fortified foods in the form of folic acid (400 µg/day) for 1 year prior. Prenatal Nutrition • Nutritional recommendations for mother and fetus to stay alive, and to support the tissue changes. • Increases in heart and respiratory rate, cardiac output, red blood cell and plasma volume, and oxygen consumption. • Enlarged heart. • Increase in appetite, thirst, metabolism, and body temperature. • More rapid kidney waste filtration, sodium and thus body water retention. Maternal Weight Gain, Part 1 • Increased body water, fat, and lean body mass Maternal Weight Gain, Part 2 Pre-Pregnancy BMI1 Underweight (BMI <18.5) Normal weight (BMI <25) Overweight (BMI 25-29.9) Obese (BMI > 30) 1 Food Pregnancy BMI2 Recommended Weight Gain 28-40 pounds Underweight (BMI <19.8) Normal weight (BMI 25-35 pounds <26) Overweight (BMI 15-25 pounds 26-29) Obese 11-20 pounds (BMI > 29) and Nutrition Board, subcommittee on nutrition status during pregnancy and lactation. 2 National Heart Lung and Blood Institute expert panel on identification, evaluation, and treatment of overweight and obesity in adults. Fetal Growth and Development, Part 1 • • • • • • • • 1st 8 weeks, embryonic development Week 9 to birth, fetal development Full term, 38 week gestation Weeks 17-20, gender determination Placenta forms from the endometrium Rapid cellular differentiation occurs Critical period, high risk of teratogenic effects Fetal growth and development is monitored by measuring the uterus and listening to fetal heart • Genetic testing for conditions like Down Syndrome or Cystic Fibrosis when indicated Fetal Growth and Development, Part 2 Birth Size, Nutrition and Health Outcomes • Birth weight, newborns 1st weight immediately after birth. – – – – Low birth weight, <5.5 lbs Small for gestational age if born at term Preemie if born > 3 weeks early Low birth weight from maternal alcohol and/or tobacco use, low prenatal weight gain, and exposure to lead, solvents, pesticides, polycyclic aromatic hydrocarbons, and air pollution – Low birth weight and preemie increases risk for health problems Energy and Nutrient Needs, Part 2 • Macronutrient recommendations are generally made for pregnancy • Micronutrient recommendations are made depending on the trimester • Energy (Calories) – – – – 1st trimester = EER 2nd trimester = EER + 340 Calories 3rd trimester = EER + 452 Calories Too few or too many Calories consumed causes negative health consequences for the baby and mother – A woman should be healthy, have a healthy body weight, and be nourished prior to becoming pregnant Carbohydrate, Protein, and Fat • Carbohydrate: 175 grams/day minimum; 45-65% of Calories; ≤25% Calories from sugars; 1.4 grams/100 Calories for fiber • Protein: 1.1 grams/Kg; 10-35% of Calories • Fat: DRI for the EFAs increase, 20-35% of Calories – Linoleic acid → arachidonic acid (AA) – alpha-linolenic acid → eicosapentaenoic acid (EPA) → docosahexaenoic acid (DHA) – DHA supports CNS growth and development and cognition – Eat low mercury fish or take a supplement Vitamins, Minerals and Water, Part 1 • Consume a healthy diet. • Take a prenatal vitamin and mineral supplement during the entire pregnancy • Most of the DRIs for the vitamins and minerals are higher during pregnancy and lactation • Adequate water is important Vitamins, Minerals and Water, Part 2 • Iron and folate for new cell synthesis • Vitamin A for gene expression, growth, and development • Calcium absorption increases and kidney excretion decreases • Iodine for thyroxin a major metabolic hormone; Inadequate levels cause mental retardation • Zinc for catalytic, structural, and regulatory roles that support growth and development • Adequate water to support metabolic waste removal, blood volume expansion, cardiovascular function, thermal regulation and metabolism Diet and Health Issues, Part 1 Nausea and Vomiting • Common and normal in the 1st trimester • Likely from hormonal changes • May occur in the morning or all day • Control by avoiding foods and beverages that are triggers and separating solid and liquid intake Constipation and Heartburn • Fiber and fluid promote regularity • Small more frequent iron supplements to prevent constipation from taking iron • Small, frequent low fat meals to prevent heartburn; also avoid foods that relax the lower esophageal sphincter and sit up-right after eating for an hour Diet and Health Issues, Part 2 Pica • Intake of non-nutritional foods like starch and clay • Culturally based, familial factors, underlying deficiencies of iron or zinc, or lead toxicity Gestational Diabetes • Transient type of diabetes, usually goes away after pregnancy, can increase risk for type 2 diabetes • Modified fasting glucose tolerance test given at the beginning of the 3rd trimester • Proper diet (with low glycemic index foods) and exercise are the best treatment Diet and Health Issues, Part 3 Preeclampsia • Very serious hypertension during pregnancy • Healthy lifestyle with adequate rest, exercise and consuming a well-balanced, antioxidant-rich for prevention. • Calcium and fish oil supplementation, reducing sodium, and taking daily aspirin for prevention. • Medication for treatment. • If untreated, increased risk for heart disease, stroke and type 2 diabetes for the mother and restricted growth and respiratory distress for the baby. • Symptoms include nausea, headache, blurred vision, and certain abnormal urine and blood tests though hypertension can be asymptomatic Diet and Health Issues, Part 4 Fetal Alcohol Syndrome • Children born to mothers who drank alcohol during their pregnancy • Preventable by not drinking alcohol during pregnancy • Visible characteristics of the head, forehead, nose, jaw, eyes, ears and lips • Cognitive and behavioral delays • Ages 3-8 years is when diagnosis is best made Diet and Health Issues, Part 5 Fish and Methylmercury • Bacteria metabolically convert inorganic mercury to methylmercury • Contaminates waterways and bioaccumulates • Crosses the placenta and causes small head size, cerebral palsy, developmental delay and/or mental retardation, blindness, muscle weakness, and seizures • Fish that are large and have long life spans have higher levels; especially avoid shark, swordfish, king mackerel, and tilefish • Consume 2-6oz servings of low methylmercury fish MyPlate for Pregnant Women Health Care MyPlate Foods to include Visit your healthcare provider regularly, more often if expecting twins, triplets, or multiple births Get your own daily food plan for moms at choosemyplate gov. Fortified cereals and wheat germ for grains Take your prescribed vitamin/mineral supplement Eat a healthy diet; Red, orange, and dark green supplements can't make up for an leafy vegetables such as unhealthy diet tomatoes, carrots, and spinach Gain an appropriate amount of weight (not Use the weight gain too much or too little) estimation tool at choosemyplate.gov Melons, citrus fruits, bananas, apricots, mangos, and prunes for fruits Discuss and be treated for your medical Limit empty Calories from solid conditions like diabetes, celiac disease, renal fats and added sugars disease, food allergies, and lactose intolerance If you need assistance to get healthy food Do not drink alcohol visit W1C and/or SNAP Fat-free or low-fat (1%) milk, yogurt, and soy milk for dairy Beans and peas, nuts and seeds, lean meats, and seafood (avoid shark, swordfish), king mackerel, and tilefish due to high mercury) for protein Prenatal Fitness and Lifestyle Management • Exercising will reduce; the loss of muscular and cardiovascular fitness; excessive maternal weight gain, the risk of gestational diabetes, preeclampsia, the development of varicose veins, deep vein thrombosis, and the complaints about low back pain and the poor psychological adjustment to physical changes of pregnancy • 30 minutes or more of moderate-intensity physical activity everyday is safe unless medical conditions • It’s best to consultation with a healthcare provider • Avoid activities with a high risk of falling, causing abdominal trauma or putting stress on the joints • Protect the breasts and avoid overheating Some Summary Points, Part 1 • Pre-conceptual nutrition affects fertility, conception, implantation and the development of the embryo and so does celiac disease and PCOS – taking a folic acid supplement is recommended. • The “fertility diet” is low in TFAs, SFAs, higher in MUFAs, vegetable proteins, fiber, low glycemic index carbohydrate sources, and adequate in all of the essential vitamins, minerals, amino acids, fatty acids, and water. • The prenatal DRIs include increased maternal and fetal nutritional needs for proper growth, development, and function. Some Summary Points, Part 2 • Prenatal weight gain and healthcare monitoring determines risk for developing medical conditions of pregnancy such as preeclampsia and gestational diabetes and promotes good nutrition. • Prenatal fitness includes; following the eating plan provided by MyPlate, taking a prenatal multivitamin and mineral supplement, engaging in regular exercise, getting plenty of rest, and being wise about lifestyle choices. References for this presentation are the same as those for this topic found in module 7 of the textbook