131 Learning Objectives Chapter 11: Intro to Organic Molecules & Functional Groups Difference between organic and inorganic molecules Name characteristic features of organic compounds Draw organic compounds, including skeletal structures Identify common bond types, angles, and molecule shapes Name functional groups Understand polarity and its effect on solubility and boiling point Explain the difference between fat and water soluble vitamins Chapter 12: Alkanes Describe alkane characteristics Draw alkanes as full, condensed, and skeletal structures Bond angle around alkane carbons Draw constitutional isomers and ID longest carbon chain ID 1°, 2°, 3°, 4° carbons Name simple alkanes and cycloalkanes Predict products of combustion & balance reaction equations Chapter 13: Unsaturated Hydrocarbons Identify unsaturated hydrocarbons: alkenes, alkynes, aromatic compounds Alkene, Alkyne, Aromatic nomenclature Stereoisomers Addition Reactions Polymers Substitution Reactions Chapter 14: Oxygen, Halogens, Sulfur Name organic compounds with carbon-heteroatom single bonds (oxygen, halogens, sulfur) Identify 1°, 2°, 3° alcohols and alkyl halides Predict the products or reactants for following reactions: Alcohol dehydration Alcohol oxidation Sulfur oxidation Sulfur reduction Chapter 15: The 3-D Shape of Molecules Understand the difference between Chiral and Achiral molecules Identify chiral centers Draw the enantiomers & diastereomers of a chiral molecule (using dashes & wedges to show geometry) Draw fischer projections of chiral molecules Explain the relevance of chiral centers in Biochemistry Chapter 16: Aldehydes & Ketones Nomenclature for aldehydes & ketones Identify structure and describe bonding of aldehydes & ketones Aldehyde oxidation without alcohol oxidation Addition reactions at C – O double bond Hemiacetal & acetal formation Identify cyclic hemiacetals Chapter 17: Carboxylic Acids, Esters, Amides Nomenclature for carboxylic acids, esters, & amides Identify and describe structure of carboxylic acids, esters & amides Acid-base chemistry of carboxylic acids (think soap!) Substitution reactions of carboxylic acids o Formation of esters o Formation of amides Hydrolysis of acyl compounds o Ester hydrolysis o Amide hydrolysis Structure & formation of polyamides & polyesters Chapter 18: Amines Identify amines and describe bonding & structure (1°, 2°, 3°) Nomenclature for amines Amine hydrogen bonding Alkaloids & Nitrogen heterocycles Acid-base chemistry of amines Neurotransmitter amines Amines and common drugs Chapter 19: Lipids Describe lipids o Properties o Hydrolyzable & nonhydrolyzable Identify fatty acids o Properties o Saturated & unsaturated Wax chemical structure Identify triglycerides & describe properties o Triglyceride hydrolysis Identify Phospholipids and Phyosphoacylglycerols Describe the structure & transport across cell membranes Identify & describe steroid hormones & their properties Identify prostaglandins & leukotrines o Describe role in asthma Chapter 20: Carbohydrates Identify carbohydrates o Describe properties and types (monosaccarides to polysaccharides) Draw Fischer projections of carbohydrates o Classify as D or L o ID multiple chiral center and draw enantiomers Draw common monosaccharieds: glucose, galactose, fructose Draw cyclic monosaccarides & identify hemiacetal o & isomers o draw Haworth projections Draw ketohexose Reduction & oxidation of monosaccharides Describe & draw disaccharides Polysaccharides: types and structures Describe blood types Chapter 21: Amino Acids, Proteins, Enzymes The 20 common, naturally occurring Amino Acids stereochemistry acid/base chemistry Peptides Formation N & C terminals Proteins Primary, Secondary, Tertiary, Quaternary structure Hydrolysis and denaturation Enzymes Catalysis Inhibitors Zymogens Chapter 22: Nucleic Acids & Protein Synthesis Nucleosides & Nucleotides: structure DNA & RNA base pairs: names & structures Phosphate addition Nucleic Acids Formation & primary structure DNA double helix structure, hydrogen bonding Replication, Transcription, Translation RNA rRNA, mRNA, tRNA Genetic Code: codon & anticodon Protein Synthesis: initiation, elongation, termination Mutations Recombinant DNA: formation & use PCR: polymerase chain reaction: technique & application Chapter 23: Metabolism & Energy Production Stages of Metabolism ATP: structure, hydrolysis, & formation Coupling reactions Coenzymes NAD+ & NADH FAD & FADH2 Coenzyme A Citric Acid Cycle: all 8 steps Electron Transport Chain ATP synthesis by Oxidative Phosphorylation Chapter 24: Carbohydrate, Lipid, Protein Metabolism Role in Metabolism of fatty acid oxidation, glycolysis, & Amino acid catabolism Reactions catalyzed by: kinase, isomerase, dehydrogenase, decarboxylase, carboxylase Glycolysis: steps & net reaction Pyruvate conversion to acetyl Coenzyme A Gluconeogenesis: steps in synthesis of glucose Catabolism of Triacylglycerols: beta-oxidation Synthesis of ketone bodies: ketogenesis Catabolism of Amino acids: transamination & oxidative deamination Ketogenic vs glucogenic amino acid catabolism