LOYOLA COLLEGE (AUTONOMOUS), CHENNAI – 600 034
M.Sc. DEGREE EXAMINATION – BIO TECHNOLOGY
IB 19
FIRST SEMESTER – APRIL 2007
BT 1816 - IMMUNOLOGY
Date & Time: 02/05/2007 / 1:00 - 4:00
Dept. No.
Max. : 100 Marks
PART – A
I.
Choose the correct answer;
1. Tears contain
a) IgE b) IgM
(5x1=5)
c) IgA d) none
2. Opsonins include
a) Granules b) C9
c) IFNγ d) C3b
3. Clonal selection
a) Necessitates that proteins are multi determinant
b) Requires that each antigen reactive cell have multiple specificities
c) Involves binding of Ab Fc regions to mast cells
d) Explains specificity and memory in immunity
4. Which one of the following cell type is least effective against extra cellular
bacterial pathogen?
a) B cells b) cytotoxic Tcells c) TNFγ d) macrophages
5. Immuno suppression is not induced by
a) anti histamines
b) removal of lymphoid tissue
c)use of anti lymphocyte antibodies d) cytotoxic drugs
II. State True or False.If false Give reasons
(5x1=5)
6. Formation and development of WBC is called as Hematopoiesis.
7. Apoptosis leads in damage to surrounding cells.
8. All TH cells express CD4 and only recognize antigen associated with class II
MHC molecule.
9. The puri potent stem cell is one of the most abundant cell types in the bone
marrow.
10. Activation of macrophages increases their expression of class I MHC
molecules making the cells more effective in antigen presentations.
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III. Complete the following:
(5x1=5)
11. HIV genome consist two copies of _____________.
12. ________________ polypeptide that joins subunits of polymeric IgA and IgM.
13. _______________ is the most major allograft organ in humanbeing.
14. _____________ is the major opsonin of the complement system.
15. Macrophages produce cytotoxic peptides known as ______________
IV. Answer the following questions, each in about 50 words.
(5x1=5)
16. What are super antigens?
17. Define knockout mice
18. Explain agglutination
19. Name different types of interferons.
20. What is ELISA?
PART-B
V. Answer any FIVE of the following questions, each in about 350 words
( 5 x 8 = 40 )
21. What are major events that occur during an inflammatory response?
22. How can you distinguish MHC molecules?
23. Explain Gell and Coombs classification of hypersensitive reaction
24. Explain the structure and function of Thymus
25. Write about immune response to viruses
26. How can you perform rocket electrophoresis to detect serum proteins?
27. Explain the process of graft rejection and acceptance
28. What are the major functions of various interleukins?
PART-C
VI. Answer any TWO the following questions, each in about 1500 words:
( 2 x 20 = 40 )
29. (a) Explain in detail about various immune deficiency diseases
(Or)
(b) What is meant by hybridoma technique and its uses?
30. (c) Draw the structure of immunoglobulin molecule. Explain the various types and functions.
(Or)
(d) Give a detail account of classical complement pathway.
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